Results 291 to 300 of about 481,400 (346)

Endoplasmic reticulum-localized circular RNA FAM13B restrains nasopharyngeal carcinoma lymphatic metastasis through downregulating XBP1. [PDF]

J Exp Clin Cancer Res
Jia GD, Xie SY, Li XY, Li LJ, Jin J, Liu LT, Sun XS, Liu SL, Chen QY, Tang LQ, Yuan L, Mai HQ.   +11 more
europepmc   +1 more source

Decoy Extracellular Vesicles Overcome Triple‐Negative Breast Cancer Heterogeneity via Membrane‐Cytoplasm‐Mitochondria Cascade Targeting

Advanced Science, EarlyView.
siT/MOF@EVs overcome TNBC heterogeneity through a tumor cell membrane–cytoplasm–mitochondria cascade effect, triggering a self‐reinforcing anti‐tumor immune cycle and durable immune memory. The system enables sequential targeting of membrane checkpoints ligands (decoy effect), cytoplasmic siRNA delivery (CSC suppression), and mitochondrial MOF ...
Chuanrong Chen, Ming Shen, Xiaofeng Wan, Lili Sheng, Na Hao, Man Li, Menglin Xu, Yang He, Jiali Zhang   +8 more
wiley   +1 more source

Decoding ischemic stroke: Perspectives on the endoplasmic reticulum, mitochondria, and their crosstalk. [PDF]

Redox Biol
Zhang C, Lan X, Wang Q, Zheng Y, Cheng J, Han J, Li C, Cheng F, Wang X.   +8 more
europepmc   +1 more source

Inhibition of FOXM1 Synergizes with BH3 Mimetics Venetoclax and Sonrotoclax in Killing Multiple Myeloma Cells through Repressing MYC Pathway

Advanced Science, EarlyView.
Relapsed and refractory multiple myeloma remains a major clinical challenge. This study shows that FOXM1 contributes to resistance against BH3 mimetics in multiple myeloma cells. The FOXM1 inhibitor NB73 enhances the effectiveness of BH3 mimetics by reducing FOXM1 expression and suppressing the MYC pathway.
Zhi Wen, Yidan Wang, Kathryn C. Fox, Adam M. Bissonnette, Luke F. Moat, Terrie E. Kitchner, Kelsey Springstroh, Sung Hoon Kim, Dagna S. Sheerar, Patcharon Tanawattanacharoen, Chady A. Leon, Seth O. Fagbemi, John A. Katzenellenbogen, Scott J. Hebbring, Benita S. Katzenellenbogen, Siegfried Janz, Adedayo A. Onitilo   +16 more
wiley   +1 more source

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

Advanced Science, EarlyView.
Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil, Josh J. Friesen, Nuthan V. Bathula, Anneke Strumpel, Chia Hao Ho, Ilana Guez, Kristen Y. S. Kong, Andrew J. Varley, Shigeki J. Miyake‐Stoner, Parinaz Aliahmad, Nathaniel S. Wang, Andrew J. Geall, Anna K. Blakney   +12 more
wiley   +1 more source

Shengyu decoction ameliorates knee osteoarthritis by inhibiting endoplasmic reticulum stress via Piezo1 channels. [PDF]

Front Pharmacol
Song X, Liu Y, Shen X, Zhang L, Kong H, Chen S, Sheng L, Sun R.   +7 more
europepmc   +1 more source

Structural Basis of GABAB Receptor Activation during Evolution

Advanced Science, EarlyView.
This study explores the structural and functional mechanisms of the drosophila GABAB receptor, a key role in neurotransmission. Using cryo‐EM, the research reveals how the receptor's activation differs from its human counterpart, highlighting unique evolutionary features.
Guofei Hou, Shenglan Zhang, Cangsong Shen, Suyu Ji, Binqian Zou, Chanjuan Xu, Liang Li, Dandan Shen, Jiayin Liang, Haidi Chen, Philippe Rondard, Cheng Deng, Jun He, Yan Zhang, Jianfeng Liu   +14 more
wiley   +1 more source

SERCA-mediated endoplasmic reticulum stress facilitates hematopoietic stem cell mobilization. [PDF]

Stem Cell Res Ther
Li L, Xu D, Huang X.
europepmc   +1 more source

Preliminary exploration of endoplasmic reticulum stress transmission in astrocytes and neurons, and its mediators. [PDF]

Mol Med Rep
Ling Y, Hayat MA, Lv X, Niu D, Zeng Y, Qiu Y, Chen B, Hu J.   +7 more
europepmc   +1 more source

Unraveling the Role of α2δ-1 in Cerebral Hemorrhage: Calcium Overload, Endoplasmic Reticulum Stress, and Microglial Apoptosis. [PDF]

Brain Behav
Yu N, Li X, Wang B, Nan C, Jin Q, Yang L, Li D, Zhao Z.   +7 more
europepmc   +1 more source