Results 281 to 290 of about 230,735 (311)

[Retracted] Salinomycin triggers prostate cancer cell apoptosis by inducing oxidative and endoplasmic reticulum stress via suppressing Nrf2 signaling. [PDF]

Exp Ther Med
Yu J, Yang Y, Li S, Meng P.
europepmc   +1 more source

Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling [PDF]

Trends in Cell Biology, 2012
Many cellular processes including apoptosis, autophagy, translation, energy metabolism, and inflammation are controlled by the mammalian target of rapamycin (mTOR) kinase and the endoplasmic reticulum (ER) stress pathway, also known as the unfolded ...
Christian Appenzeller-Herzog, Michael N Hall   +1 more
exaly   +2 more sources

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Endoplasmic Reticulum Stress

Annals of the New York Academy of Sciences, 2007
Abstract:  Stress is the imbalance of homeostasis, which can be sensed even at the subcellular level. The stress‐sensing capability of various organelles including the endoplasmic reticulum (ER) has been described. It has become evident that acute or prolonged ER stress plays an important role in many human diseases; especially those involving organs ...
BANHEGYI G, BAUMEISTER P, BENEDETTI A, DONG D, FU Y, LEE AS, LI J, MAO C, MARGITTAI E, NI M, PASCHEN W, PICCIRELLA S, SENESI S, SITIA , ROBERTO, WANG M, YANG W.   +15 more
openaire   +3 more sources

Serpinopathy and endoplasmic reticulum stress

Medical Molecular Morphology, 2005
We have recently identified a novel human gene, megsin, which is a new serine protease inhibitor (serpin) predominantly expressed in the kidney. Our previous studies suggested a role of megsin in the pathogenesis of human renal diseases, but its exact biopathological significance remained unknown.
Toshio, Miyata, Reiko, Inagi, Satoshi, Sugiyama, Nobuteru, Usuda   +3 more
openaire   +2 more sources

Endoplasmic Reticulum Stress in Immunity

Annual Review of Immunology, 2015
Immune responses occur in the midst of a variety of cellular stresses that can severely perturb endoplasmic reticulum (ER) function. The unfolded protein response is a three-pronged signaling axis dedicated to preserving ER homeostasis. In this review, we highlight many important and emerging functional roles for ER stress in immunity, focusing on how ...
Sarah E, Bettigole, Laurie H, Glimcher
openaire   +2 more sources

Parkin and Endoplasmic Reticulum Stress

Annals of the New York Academy of Sciences, 2003
Abstract: Autosomal‐recessive juvenile parkinsonism (AR‐JP) is caused by mutations in the parkin gene. Parkin protein is characterized by a ubiquitin‐like domain at its NH2 terminus and by two RING finger motifs and one IBR (in between RING finger) motif at its COOH‐terminus (RING‐IBR‐RING). We showed that the parkin protein is an E3 ubiquitin ligase,
Ryosuke, Takahashi, Yuzuru, Imai, Nobutaka, Hattori, Yoshikuni, Mizuno   +3 more
openaire   +2 more sources

Sensing Endoplasmic Reticulum Stress

2012
This chapter provides an overview of our present understanding of mechanisms of sensing protein folding status and endoplasmic reticulum (ER) stress in eukaryotic cells. The ER folds and matures most secretory and transmembrane proteins. Mis- or unfolded proteins are sensed by specialized ER stress sensors, such as IRE1, PERK and ATF6, which initiate ...
Vipul M, Parmar, Martin, Schröder
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InterfERing with endoplasmic reticulum stress

Trends in Pharmacological Sciences, 2012
Stress to the endoplasmic reticulum (ER) is a recognized factor in Alzheimer's and Parkinson's diseases, diabetes, heart disease, liver disorders and cancer. Thus, drugs that interfere with ER stress have wide therapeutic potential. Here we review the effects of drugs on three arms of ER stress: the protein kinase RNA-activated (PKR)-like ER kinase ...
Honorata, Kraskiewicz, Una, FitzGerald
openaire   +2 more sources