Results 291 to 300 of about 462,885 (376)

Acetylation of the Mitochondrial Chaperone GRP75 Governs ER‐Mitochondrial Calcium Homeostasis and Hepatocyte Insulin Resistance

Advanced Science, EarlyView.
Overnutrition exacerbates insulin resistance (IR) and is linked to excessive mitochondrial protein acetylation. However, it remains unclear whether and how mitochondrial protein acetylation influences IR. GCN5L1‐dependent downregulation of GRP75 acetylation at K567/612 consequently enhances ER‐mitochondrial calcium flux and induces ER stress.
Danni Wang, Jiaqi Zhang, Xinyu Yang, Qiqi Zhang, Xiuya Hu, Xin Lu, Hanni Li, Xue Bai, Kai Zhang, Michael N. Sack, Yongsheng Chang, Yingmei Wang, Lingdi Wang, Lu Zhu   +13 more
wiley   +1 more source

Endoplasmic reticulum stress: an emerging therapeutic target for preeclampsia†. [PDF]

Biol Reprod
Chen M, Jin Y, Cao X.
europepmc   +1 more source

Deficiency of ATP2C1, a Golgi Ion Pump, Induces Secretory Pathway Defects in Endoplasmic Reticulum (ER)-associated Degradation and Sensitivity to ER Stress [PDF]

, 2004
José Ramos‐Castañeda, Young-nam Park, Ming Liu, Karin Hauser, Hans K. Rudolph, Gary E. Shull, Marcel F. Jonkman, Kazutoshi Mori, Shigaku Ikeda, Hideoki Ogawa, Peter Arvan   +10 more
openalex   +1 more source

Novel Swelling‐Lytic Cell Death Triggered by Cargo‐Free Ionizable Lipid Nanoparticles

Advanced Science, EarlyView.
A cargo‐free ionizable lipid nanoparticles (ipLNP) is found to induce broad swelling‐lytic cell death across multiple cell types. Cell death may be associated with lysosome membrane destabilization, involving ROS increase, lipid peroxidation, and GSDME cleavage.
Junjun Wu, Zhennan Zhao, Hongsheng Wu, Sihuang Lin, Lin Huang, Guanjie Chen, Yi Yang, Hong Wang, Huijie Yan, Yonghui Shi, Liuyu Zhu, Guosheng Hu, Liling Zheng, Songying Ouyang   +13 more
wiley   +1 more source

Human immunodeficiency virus 1 glycoprotein 120 induces endoplasmic reticulum stress in neurons. [PDF]

Cell Death Dis
Agbey C, Campbell LA, Phan T, Ahern G, Mocchetti I.   +4 more
europepmc   +1 more source

Endoplasmic reticulum stress as a correlate of cytotoxicity in human tumor cells exposed to diindolylmethane in vitro [PDF]

, 2004
Shishinn Sun, Jing Han, W Ralph, Alamelu Chandrasekaran, Kai Liu, Karen J. Auborn, Timothy H. Carter   +6 more
openalex   +1 more source

Endoplasmic Reticulum Stress Signaling in Cancer Cells.

American Journal of Pathology, 2020
Scott A Oakes
semanticscholar   +1 more source

A Coding SNP in GmPM30 Enhances Soybean Salinity Tolerance and Yield through the GmLEA1‐GmPM30‐GmLEC1 Module

Advanced Science, EarlyView.
A natural variation in soybean PM30, GmPM30‐HapT, confers greater salt tolerance than GmPM30‐HapC via stronger GmLEA1‐GmPM30‐GmLEC1 interactions. Pyramiding their elite haplotypes yields additive gains in salt tolerance and yield, establishing a novel workflow linking evolutionary genomics, molecular mechanisms, and breeding applications via the module
Shiyu Huang, Yuhan Xia, Jingting Yang, Yujun Si, Xue Chen, Hao Zhang, Tianshi Liu, Wenyu Zheng, Xin Chen, Zhongjuan Zhao, Xiaojian Zheng, Qing Lu, Shuo Li, Fengning Xiang   +13 more
wiley   +1 more source

The role of Atp2a2-mediated calcium imbalance and endoplasmic reticulum stress in hydrocortisone-induced neurotoxicity. [PDF]

Cell Stress Chaperones
Kong W, Jiang P, Miao X, Sang B, Hu S, Feng L.   +5 more
europepmc   +1 more source

Polarization‐Sensitive Holotomography for Multidimensional Label‐Free Imaging and Characterization of Lipid Droplets in Cancer Cells

Advanced Science, EarlyView.
Polarization‐sensitive holotomography (PS‐HT) enables label‐free 3D imaging and quantitative analysis of lipid droplets by exploiting their intrinsic birefringence. Applied to prostate cell models, PS‐HT reveals glucose‐induced lipid accumulation in cancer cells and achieves near‐perfect classification of healthy and cancerous states.
Hossein Khadem, Maria Mangini, Maria Antonietta Ferrara, Anna Chiara De Luca, Giuseppe Coppola   +4 more
wiley   +1 more source