Results 31 to 40 of about 6,098 (159)

A Novel Endoribonuclease, RNase LS, in Escherichia coli [PDF]

Genetics, 2005
Abstract The dmd gene of bacteriophage T4 is required for the stability of late-gene mRNAs. When this gene is mutated, late genes are globally silenced because of rapid degradation of their mRNAs. Our previous work suggested that a novel Escherichia coli endonuclease, RNase LS, is responsible for the rapid degradation of mRNAs.
Yuichi Otsuka, Tetsuro Yonesaki
openaire   +3 more sources

Structure, Evolution, and Functions of Bacterial Type III Toxin-Antitoxin Systems. [PDF]

, 2016
Toxin-antitoxin (TA) systems are small genetic modules that encode a toxin (that targets an essential cellular process) and an antitoxin that neutralises or suppresses the deleterious effect of the toxin.
Chai, Ray, Chen, Bihe, Day, Andrew, Goeders, Nathalie, Salmond, George PC   +4 more
core   +3 more sources

Protonated Glutamate and Aspartate Side Chains Can Recognize Phosphodiester Groups via Strong and Short Hydrogen Bonds in Biomacromolecular Complexes

Angewandte Chemie International Edition, EarlyView.
The highly negatively charged phosphodiester groups of nucleic acids and cyclic (di‐)nucleotides often interact with amino acids containing polar or positively charged sidechains. Due to charge repulsion with their negatively charged carboxylate groups in their side chains, glutamate and aspartate are considered to be detrimental to such interactions ...
Konstantin Neißner, Elke Duchardt‐Ferner, Christoph Wiedemann, Julian Kraus, Ute A. Hellmich, Jens Wöhnert   +5 more
wiley   +1 more source

A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small RNAs for broad applications. [PDF]

, 2015
RNA research and therapy relies primarily on synthetic RNAs. We employed recombinant RNA technology toward large-scale production of pre-miRNA agents in bacteria, but found the majority of target RNAs were not or negligibly expressed. We thus developed a
Chen, Qiu-Xia, Urayama, Shiro, Wang, Wei-Peng, Yu, Ai-Ming, Zeng, Su   +4 more
core   +2 more sources

Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley   +1 more source

New insights into control of arbovirus replication and spread by insect RNA interference pathways [PDF]

, 2012
Arthropod-borne (arbo) viruses are transmitted by vectors, such as mosquitoes, to susceptible vertebrates. Recent research has shown that arbovirus replication and spread in mosquitoes is not passively tolerated but induces host responses to control ...
Andersson, Angelini, Angelini, Arensburger, Arensburger, Attarzadeh-Yazdi, Berry, Blevins, Brackney, Chung, Cirimotich, Cohen, Czech, Ding, Dubrulle, Fagegaltier, Flynt, Franz, Ghildiyal, Henke, Holt, Hussain, Hussain, Iwasaki, Kaminker, Kawamura, Keene, Kwon, Lagos-Quintana, Li, Lim, Lucchetta, Mendes, Morazzani, Mueller, Myles, Nene, Qi, Rezza, Ruby, Saleh, Sanchez-Vargas, Schwarz, Selbach, Sijen, Siu, Skalsky, Tam, Thibault, Vodovar, Watanabe, Waterhouse, Wu, Yan, Zeiner, Zeng   +55 more
core   +3 more sources

Investigation of endoplasmic reticulum stress parameters in patients with gestational diabetes mellitus: A prospective study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Our aim in this study was to evaluate the levels of Activating Transcription Factor‐6 (ATF‐6), Inositol‐Requiring Enzyme 1 (IRE‐1), and C/EBP‐Homologous Protein (CHOP), which are critical markers of endoplasmic reticulum (ER) stress, in patients with gestational diabetes mellitus (GDM), a condition increasingly recognized for its ...
Sevcan Sarıkaya, Eissa Almaghrebi, Fatma Akat, Eda Nur Hepbildi, Esra Kosucu, Muslu Kazım Körez, Husamettin Vatansev   +6 more
wiley   +1 more source

Circulating genomic biomarkers predict chemoradiotherapy resistance and immunotherapy response in locally advanced non‐small‐cell lung cancer

VIEW, EarlyView.
The insufficient sensitivity of single circulating tumor DNA (ctDNA)‐molecular residual disease (MRD) prediction remains unresolved and hinders the clinical implementation of ctDNA. Through prospective cohort study, independent validations, and mechanism exploration from peripheral blood and tumor tissue, we demonstrate that ctDNA‐based STK11/KEAP1 ...
Yu Wang, Canjun Li, Tao Zhang, Jianyang Wang, Wenyang Liu, Lei Deng, Ying Jiang, Jinghao Duan, Luhua Wang, Hong Ge, Nan Bi   +10 more
wiley   +1 more source

Salicylic acid collaborates with gene silencing to tomato defense against tomato yellow leaf curl virus (TYLCV) [PDF]

, 2018
Antiviral research in plants has been focused on RNA silencing (i.e. RNA interference), and several studies suggest that salicylic acid (SA)-mediated resistance is a key part of plant antiviral defense.
Crabbe, M. James C., Li, Yunzhou, Liang, Yan, Muhammad, Tayab, Wang, Yong, Zhang, Dalong   +5 more
core  

IL‐25 Enhances B Cell Responses in Type 2 Inflammation Through IL‐17RB Receptor

Allergy, Volume 80, Issue 4, Page 965-975, April 2025.
Human B cells express IL‐17RB under IgE inducing conditions (anti‐CD40 + IL‐4) and respond to IL‐25 with enhanced antibody production, particularly IgE. ScRNA‐seq revealed that IL‐17RB+ B cells have a distinct transcriptional profile compared to IL‐17RB‐B cells.
Semah Abdu, Jiao Xia, Huihui Yuan, Tiak Ju Tan, Janice A. Layhadi, Mohamed H. Shamji, Andrew N. J. McKenzie, Nora Haloob, Claire Hopkins, Grzegorz Woszczek, Stephen J. Till   +10 more
wiley   +1 more source