Results 41 to 50 of about 5,190 (143)

Quorum Sensing Extracellular Death Peptides Enhance the Endoribonucleolytic Activities of Mycobacterium tuberculosis MazF Toxins

mBio, 2018
mazEF is a toxin-antitoxin module located on chromosomes of most bacteria. MazF toxins are endoribonucleases antagonized by MazE antitoxins. Previously, we characterized several quorum sensing peptides called "extracellular death factors" (EDFs).
Akanksha Nigam, Sathish Kumar, Hanna Engelberg-Kulka   +2 more
doaj   +1 more source

Unusual Cytology Features of A DICER1‐Mutated Thyroid Nodule: Raising Awareness of A Potential Diagnostic Pitfall During Fine Needle Aspiration

Cytopathology, EarlyView.
This article describes the unusual cytology features of a DICER1‐mutated thyroid nodule. Fine needle aspiration revealed predominantly cell debris/degenerated cells and rare viable follicular cells with mild cytologic atypia. Surgical resection revealed a nodule with nearly complete infarction, which is one specific feature of DICER1‐mutated thyroid ...
Wenli Dai, Eduardo V. Zambrano, Sabri Yilmaz, Qian Wang   +3 more
wiley   +1 more source

Structure of the MIWI endoribonuclease bound to pachytene piRNAs from mouse testes

Cell Reports
Summary: PIWI-interacting RNAs (piRNAs) guide PIWI endoribonucleases to destroy transposon transcripts, ensuring animal fertility. Here, we report the cryo-electron microscopy structure of the MIWI-pachytene piRNA complex isolated from mouse testes.
Nicole Raad, Carmen Fernandez-Rodriguez, Radha Raman Pandey, Inayathulla Mohammed, Emiko Uchikawa, Fabienne Burger, David Homolka, Ramesh S. Pillai   +7 more
doaj   +1 more source

Novel specificity of an endoribonuclease of yeast [PDF]

FEBS Letters, 1986
Investigations of the cleavage specificity of a cyclizing endoribonuclease of yeast show that it hydrolyzes Y‐A bonds of single‐stranded regions of RNA and that oligonucleotides are hydrolyzed poorly. The stringent specificity of the enzyme suggests that it may be useful for generating specific fragments of polyribonucleotides.
openaire   +2 more sources

Turkey Coronavirus Non-Structure Protein NSP15 – An Endoribonuclease [PDF]

Intervirology, 2008
Turkey coronavirus (TCoV) polyprotein was predicted to be cleaved into 15 non-structural proteins (nsp2 to nsp16), but none of these nsps have been characterized. TCoV nsp15 consists of 338 residues and shares 40% sequence similarity to U-specific <i>Nidovirales</i> endoribonuclease (NendoU) of severe acute respiratory syndrome coronavirus.
Jianzhong, Cao, Ching-Ching, Wu, Tsang Long, Lin   +2 more
openaire   +2 more sources

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Conjugated polymer nanoparticles for effective siRNA delivery to tobacco BY-2 protoplasts

BMC Plant Biology, 2010
Background Post transcriptional gene silencing (PTGS) is a mechanism harnessed by plant biologists to knock down gene expression. siRNAs contribute to PTGS that are synthesized from mRNAs or viral RNAs and function to guide cellular endoribonucleases to ...
Verchot Jeanmarie, Ye Changming, Nguyen Alien, Silva Asitha T, Moon Joong   +4 more
doaj   +1 more source

Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA‐Seq Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Aim The dental pulp is an immunologically active tissue that responds dynamically to cariogenic challenge. Peripheral pulp cells adjacent to dentine encounter bacterial stimuli earlier than cells located in the central pulp. To investigate signalling and immune interactions, this study profiled the transcriptomes of dentine‐adherent cells ...
Sandra Pohl, Maximilian L. Huber, Tobias Akamp, Andreas Rosendahl, Melanie Linnebank, Lea Schreiber, Claudia Gebhard, Nicholas Strieder, Michael Rehli, Wolfgang Buchalla, Matthias Widbiller   +10 more
wiley   +1 more source

Endoribonucleases associated with RNAs in chick embryos

FEBS Letters, 1979
proteins in hemopoietic rat cells were reported to have RNase activities [ 121. Similarly, an endogeneous endoribonucleolytic activity was found in the 50 S ribosomal subunit of Eschenihia coli [ 131. This paper describes the existence of a RNA-bound cytoplasmic endoribonuclease in chick embryo.
Denoya, Claudio D., Scodeller, Eduardo A., La torre, José L.   +2 more
openaire   +2 more sources

A Novel Endoribonuclease, RNase LS, in Escherichia coli [PDF]

Genetics, 2005
Abstract The dmd gene of bacteriophage T4 is required for the stability of late-gene mRNAs. When this gene is mutated, late genes are globally silenced because of rapid degradation of their mRNAs. Our previous work suggested that a novel Escherichia coli endonuclease, RNase LS, is responsible for the rapid degradation of mRNAs.
Yuichi, Otsuka, Tetsuro, Yonesaki
openaire   +2 more sources