Results 41 to 50 of about 5,849 (189)
Phylogenetic Analysis of the Endoribonuclease Dicer Family
PLoS ONE, 2014 Dicers are proteins of the ribonuclease III family with the ability to process dsRNA, involved in regulation of gene expression at the post-transcriptional level. Dicers are conserved from basal metazoans to higher metazoans and contain a number of functional domains that interact with dsRNA.
Zeqian Gao +4 more
openaire +5 more sources
mBio, 2018 mazEF is a toxin-antitoxin module located on chromosomes of most bacteria. MazF toxins are endoribonucleases antagonized by MazE antitoxins. Previously, we characterized several quorum sensing peptides called "extracellular death factors" (EDFs).
Akanksha Nigam +2 more
doaj +1 more source
iNew Medicine, EarlyView.ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi +14 more
wiley +1 more source
Structure of the MIWI endoribonuclease bound to pachytene piRNAs from mouse testes
Cell ReportsSummary: PIWI-interacting RNAs (piRNAs) guide PIWI endoribonucleases to destroy transposon transcripts, ensuring animal fertility. Here, we report the cryo-electron microscopy structure of the MIWI-pachytene piRNA complex isolated from mouse testes.
Nicole Raad +7 more
doaj +1 more source
Conjugated polymer nanoparticles for effective siRNA delivery to tobacco BY-2 protoplasts
BMC Plant Biology, 2010 Background Post transcriptional gene silencing (PTGS) is a mechanism harnessed by plant biologists to knock down gene expression. siRNAs contribute to PTGS that are synthesized from mRNAs or viral RNAs and function to guide cellular endoribonucleases to ...
Verchot Jeanmarie +4 more
doaj +1 more source
Review 2: "Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease Variants" [PDF]
, 2022 Katja Lammens
openalex +1 more source
Cytopathology, EarlyView.This article describes the unusual cytology features of a DICER1‐mutated thyroid nodule. Fine needle aspiration revealed predominantly cell debris/degenerated cells and rare viable follicular cells with mild cytologic atypia. Surgical resection revealed a nodule with nearly complete infarction, which is one specific feature of DICER1‐mutated thyroid ...
Wenli Dai +3 more
wiley +1 more source
Novel specificity of an endoribonuclease of yeast [PDF]
FEBS Letters, 1986 Investigations of the cleavage specificity of a cyclizing endoribonuclease of yeast show that it hydrolyzes Y‐A bonds of single‐stranded regions of RNA and that oligonucleotides are hydrolyzed poorly. The stringent specificity of the enzyme suggests that it may be useful for generating specific fragments of polyribonucleotides.
openaire +2 more sources
Turkey Coronavirus Non-Structure Protein NSP15 – An Endoribonuclease [PDF]
Intervirology, 2008 Turkey coronavirus (TCoV) polyprotein was predicted to be cleaved into 15 non-structural proteins (nsp2 to nsp16), but none of these nsps have been characterized. TCoV nsp15 consists of 338 residues and shares 40% sequence similarity to U-specific <i>Nidovirales</i> endoribonuclease (NendoU) of severe acute respiratory syndrome coronavirus.
Jianzhong, Cao +2 more
openaire +2 more sources
Molecular Microbiology, EarlyView.Under iron‐limited conditions, FsrA base‐pairs with the intergenic region between epeX and epeE, enhancing epeE translation and triggering EPE production. Toxin‐mediated cell lysis releases nutrients, including iron, which can be taken up by surviving cells.
Sarah Miercke +3 more
wiley +1 more source