Results 51 to 60 of about 9,566 (262)

Functional plasticity of antibacterial EndoU toxins. [PDF]

, 2018
Bacteria use several different secretion systems to deliver toxic EndoU ribonucleases into neighboring cells. Here, we present the first structure of a prokaryotic EndoU toxin in complex with its cognate immunity protein.
Eschenfeldt, William H, Goulding, Celia W, Hayes, Christopher S, Joachimiak, Andrzej, Jones, Allison M, Koskiniemi, Sanna, Low, David A, Michalska, Karolina, Nguyen, Josephine Y, Quan Nhan, Dinh, Stols, Lucy M, Willett, Julia LE   +11 more
core   +1 more source

Iron Deprivation in Synechocystis : Inference of Pathways, Non-coding RNAs, and Regulatory Elements from Comprehensive Expression Profiling [PDF]

, 2012
Iron is an essential cofactor in many metabolic reactions. Mechanisms controlling iron homeostasis need to respond rapidly to changes in extracellular conditions, but they must also keep the concentration of intracellular iron under strict control to ...
Barreira, L, Futschik, ME, Georg, J, Hernández-Prieto, MA, Hess, WR, Schön, V, Varela, J   +6 more
core   +2 more sources

A Novel Family of Sequence-specific Endoribonucleases Associated with the Clustered Regularly Interspaced Short Palindromic Repeats*

Journal of Biological Chemistry, 2008
Clustered regularly interspaced short palindromic repeats (CRISPRs) together with the associated CAS proteins protect microbial cells from invasion by foreign genetic elements using presently unknown molecular mechanisms.
N. Beloglazova, Greg Brown, M. Zimmerman, Michael Proudfoot, K. Makarova, M. Kudritska, Samvel Kochinyan, Shuren Wang, M. Chruszcz, W. Minor, E. Koonin, A. Edwards, A. Savchenko, A. Yakunin   +13 more
semanticscholar   +1 more source

Reversible and irreversible inhibitors of coronavirus Nsp15 endoribonuclease

Journal of Biological Chemistry, 2023
The emergence of severe acute respiratory syndrome coronavirus 2, the causative agent of coronavirus disease 2019, has resulted in the largest pandemic in recent history. Current therapeutic strategies to mitigate this disease have focused on the development of vaccines and on drugs that inhibit the viral 3CL protease or RNA-dependent RNA polymerase ...
Jerry Chen, Rabih Abou Farraj, Daniel Limonta, Seyed Amir Tabatabaei Dakhili, Evan M. Kerek, Ashim Bhattacharya, Filip M. Reformat, Ola M. Mabrouk, Benjamin Brigant, Tom A. Pfeifer, Mark T. McDermott, John R. Ussher, Tom C. Hobman, J.N. Mark Glover, Basil P. Hubbard   +14 more
openaire   +2 more sources

Global analyses of small interfering RNAs derived from Bamboo mosaic virus and its associated satellite RNAs in different plants. [PDF]

PLoS ONE, 2010
BACKGROUND: Satellite RNAs (satRNAs), virus parasites, are exclusively associated with plant virus infection and have attracted much interest over the last 3 decades.
Kuan-Yu Lin, Chi-Ping Cheng, Bill Chia-Han Chang, Wei-Chi Wang, Ying-Wen Huang, Yun-Shien Lee, Hsien-Da Huang, Yau-Heiu Hsu, Na-Sheng Lin   +8 more
doaj   +1 more source

Effects of dicer-like endoribonucleases 2 and 4 on infection of Arabidopsis thaliana by cucumber mosaic virus and a mutant virus lacking the 2b counter-defence protein gene.

Journal of General Virology, 2009
In tobacco and Nicotiana benthamiana, limited cross-protection against cucumber mosaic virus strain Fny (Fny-CMV) was provided by prior inoculation with a deletion mutant lacking the 2b silencing-suppressor protein gene (Fny-CMVDelta2b). Cross-protection
H. Ziebell, J. Carr
semanticscholar   +1 more source

Characterization of Echinostoma cinetorchis endoribonuclease, RNase H [PDF]

The Korean Journal of Parasitology, 2017
Echinostoma cinetorchis is an oriental intestinal fluke causing significant pathological damage to the small intestine. The aim of this study was to determine a full-length cDNA sequence of E. cinetorchis endoribonuclease (RNase H; EcRNH) and to elucidate its molecular biological characters.
Sung-Bin Lim, Seung Jegal, Seok Ho Cha, Young Yil Bakh, Hojong Jun, Tong-Soo Kim, Jhang Ho Pak, Bo-Young Jeon, Seo Hye Park, Hyeong-Woo Lee   +9 more
openaire   +2 more sources

Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation. [PDF]

, 2014
OBJECTIVES: Interleukin (IL)-23 has been implicated in the pathogenesis of ankylosing spondylitis (AS). The aim of the study was to clarify the mechanisms underlying the increased IL-23 expression in the gut of AS patients.
Accardo Palumbo,A, ALESSANDRO, Riccardo, Cannizzaro, A, CICCIA, Francesco, Colbert, RA, GIARDINA, Annarita, GUGGINO, Giuliana, RAIMONDO, Stefania, Rizzo,A, TRIOLO, Giovanni   +9 more
core   +1 more source

Activation of an Endoribonuclease by Non-intein Protein Splicing [PDF]

Journal of Biological Chemistry, 2016
The Chlamydomonas reinhardtii chloroplast-localized poly(A)-binding protein RB47 is predicted to contain a non-conserved linker (NCL) sequence flanked by highly conserved N- and C-terminal sequences, based on the corresponding cDNA. RB47 was purified from chloroplasts in association with an endoribonuclease activity; however, protein sequencing failed ...
Stephen J. Campbell, David B. Stern
openaire   +3 more sources

Molecular mechanisms of CRISPR-mediated microbial immunity [PDF]

, 2013
Bacteriophages (phages) infect bacteria in order to replicate and burst out of the host, killing the cell, when reproduction is completed. Thus, from a bacterial perspective, phages pose a persistent lethal threat to bacterial populations.
Giedrius Gasiunas, Tomas Sinkunas, Virginijus Siksnys   +2 more
core   +1 more source