Results 51 to 60 of about 6,098 (159)

The Lepidopteran endoribonuclease-U domain protein P102 displays dramatically reduced enzymatic activity and forms functional amyloids [PDF]

, 2014
Hemocytes of Heliothis virescens (F.) (Lepidoptera, Noctuidae) larvae produce a protein, P102, with a putative endoribonuclease-U domain. In previous works we have shown that P102 is involved in Lepidopteran immune response by forming amyloid fibrils ...
Falabella, P., Grimaldi, A., Laurino, S., Monn\ue9, M., Pascale, M., Riviello, L., Tettamanti, G., Vogel, H.   +7 more
core   +1 more source

Nimbolide Targeting SIRT1 Protects Against Acetaminophen‐Induced Acute Liver Injury by Regulating Oxidative Stress and Endoplasmic Reticulum Stress

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT Acetaminophen (APAP) is a major cause of acute liver injury (ALI), and N‐acetylcysteine is the only approved detoxification drug. Nimbolide (Nim), which is isolated from the neem tree (Azadirachta indica), possesses protective properties against multiple diseases, including pancreatitis, autoimmune hepatitis, arthritis, and diabetic ...
Junhui Ba, Yunsen Lin, Jingcong Zhang, Yanhong Wang, Benquan Wu   +4 more
wiley   +1 more source

Pyrimidine-specific cleavage by an endoribonuclease of Saccharomyces cerevisiae [PDF]

Journal of Bacteriology, 1985
An endoribonuclease with pyrimidine cleavage site specificity was isolated from Saccharomyces cerevisiae. The enzyme had a pH optimum of 6 to 7 and did not require a divalent cation. It was inhibited by 5 X 10(-5) M ethidium bromide, although it appeared to be single strand specific.
openaire   +3 more sources

RNA Processing [PDF]

, 2019
International audienceRNAs can be either transcribed directly as functional species or as molecules that require post-transcriptional processing by ribonucleases.
Baumgardt, Bechhofer, Braun, Condon, Condon, Dunn, Even, Gilet, Li, Li, Mathy, Pellegrini, Redko, Sirdeshmukh, Yao   +14 more
core   +1 more source

Defective Processing of Cytoplasmic and Chloroplast Ribosomal RNA in the Absence of Arabidopsis DXO1

Plant, Cell &Environment, Volume 48, Issue 6, Page 4227-4244, June 2025.
ABSTRACT Decapping 5′‐3′ exoribonucleases from the DXO/Rai1 family are highly conserved among eukaryotes and exhibit diverse enzymatic activities depending on the organism. The biochemical and structural properties of the plant DXO1 differ from the yeast and animal counterparts, which is reflected in the in vivo functions of this enzyme.
Monika Zakrzewska‐Placzek, Anna Golisz‐Mocydlarz, Aleksandra Kwasnik, Michal Krzyszton, Katarzyna Niedzwiecka, Joanna Kufel   +5 more
wiley   +1 more source

Glioblastoma invasion and cooption depend on IRE1α endoribonuclease activity

Oncotarget, 2015
IRE1α is an endoplasmic reticulum (ER)-resident transmembrane signaling protein and a cellular stress sensor. The protein harbors a cytosolic dual kinase/endoribonuclease activity required for adaptive responses to micro-environmental changes. In an orthotopic xenograft model of human glioma, invalidation of IRE1α RNase or/and kinase activities ...
Jabouille, Arnaud, Delugin, Maylis, Pineau, Raphäel, Dubrac, Alexandre, Soulet, Fabienne, Lhomond, Stéphanie, Pallares-Lupon, Nestor, Prats, Hervé, Bikfalvi, Andreas, Chevet, Eric, Touriol, Christian, Moenner, Michel   +11 more
openaire   +7 more sources

Rex1p Deficiency Leads to Accumulation of Precursor Initiator tRNA\u3csup\u3eMet\u3c/sup\u3e and Polyadenylation of Substrate RNAs in \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e [PDF]

, 2009
A synthetic genetic array was used to identify lethal and slow-growth phenotypes produced when a mutation in TRM6, which encodes a tRNA modification enzyme subunit, was combined with the deletion of any non-essential gene in Saccharomyces cerevisiae.
Anderson, James T., Boone, Charles, Brost, Renee L., Costanzo, Michael, Ozanick, Sarah G., Wang, Xuying   +5 more
core   +1 more source

Functional plasticity of antibacterial EndoU toxins. [PDF]

, 2018
Bacteria use several different secretion systems to deliver toxic EndoU ribonucleases into neighboring cells. Here, we present the first structure of a prokaryotic EndoU toxin in complex with its cognate immunity protein.
Eschenfeldt, William H, Goulding, Celia W, Hayes, Christopher S, Joachimiak, Andrzej, Jones, Allison M, Koskiniemi, Sanna, Low, David A, Michalska, Karolina, Nguyen, Josephine Y, Quan Nhan, Dinh, Stols, Lucy M, Willett, Julia LE   +11 more
core   +1 more source

The RNA‐Binding Proteins MCPIP2 and IGF2BP1 Competitively Modulate Breast Tumor Angiogenesis by Antagonizing VEGFA mRNA Stability and Expression

The FASEB Journal, Volume 39, Issue 10, 31 May 2025.
A proposed model showed that the RNA binding proteins MCPIP2 and IGF2BP1 competitively regulate the stability and expression of proangiogenic transcripts in tumor cells. MCPIP2 decays proangiogenic mRNAs by binding to the conserved stem–loop structure in the 3ʹ UTR via its RNase domain, resulting in inhibition of proangiogenic gene expression and ...
Wenbao Lu, Hongwei Li, Xueting Liu, Ailing Li, Ruijuan Xiu   +4 more
wiley   +1 more source

RETRACTED: The RasGAP-associated endoribonuclease G3BP assembles stress granules [PDF]

The Journal of Cell Biology, 2003
Stress granules (SGs) are formed in the cytoplasm in response to various toxic agents, and are believed to play a critical role in the regulation of mRNA metabolism during stress. In SGs, mRNAs are stored in an abortive translation initiation complex that can be routed to either translation initiation or degradation.
Tourriere, H., Chebli, K., Zekri, L., Courselaud, B., Blanchard, J. M., Bertrand, Edouard, Tazi, J.   +6 more
openaire   +4 more sources