Results 271 to 280 of about 47,261 (313)

Multifunctional tumor vaccines carrying thalidomide regulate T cell exhaustion and ferroptosis for immunotherapy strategies

VIEW, Volume 7, Issue 1, February 2026.
MTV can greatly achieved antigen presenting cell (APCs), and THA will be released from the polyplex core and enhanced antigen presenting, thereby prompting APC maturation and antigen presenting. The membrane antigens on MTV are degraded into small peptides by proteasomes and presented by MHC complexes.
Anmin Huang, Ting Li, Ying Zhou, Sihang Li, Jian Zhang, Yingchao Li, Shijia Wu, Yifan Kong, Zhijie Yu, Jinglin Xia   +9 more
wiley   +1 more source

Polymeric carriers in non-viral gene delivery: a study of physicochemical properties and biological activity in human RPE cell line (Polymeeriset kuljettimet geeninsiirrossa: tutkimus fysikaalis-kemiallisista ominaisuuksista ja biologisesta aktiivisuudesta ihmisen retinan pigmentti-epiteelisoluissa) [PDF]

Männistö, Marjo
core  

Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization

Aging Cell, Volume 25, Issue 2, February 2026.
Synaptic vesicle glycoprotein 2A, the newly identified APP‐binding protein, reduces amyloid‐β plaque deposition in Alzheimer's disease by suppressing the amyloidogenic pathway through inhibition of BACE1‐APP interaction and alteration of APP endosomal‐lysosomal localization.
Xiaoling Wang, Qian Zhang, Xiaomin Zhang, Jing Liu, Jingjing Zhang, Congcong Liu, Yuting Cui, Qiao Song, Yuli Hou, Yaqi Wang, Min Cao, Peichang Wang   +11 more
wiley   +1 more source

Enhancing Endosomal Escape and Gene Regulation Activity for Spherical Nucleic Acids. [PDF]

Small
Park J, Evangelopoulos M, Vasher MK, Kudruk S, Ramani N, Mayer V, Solivan AC, Lee A, Mirkin CA.   +8 more
europepmc   +1 more source

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, Volume 59, Issue 2, February 2026.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

Anti-JNK2 peptide–siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice [PDF]

, 2018
Akk, Antonina, Bacon, John, Hou, Kirk K, Miller, Mark J, Palekar, Rohun U, Pan, Hua, Pham, Christine T.N, Schlesinger, Paul H, Springer, Luke E, Wickline, Samuel A, Yan, Huimin, Yang, Lihua   +11 more
core   +1 more source

siRNA-loaded poly(histidine-arginine)6-modified chitosan nanoparticle with enhanced cell-penetrating and endosomal escape capacities for suppressing breast tumor metastasis

, 2017
Peng Sun, W Huang, L Kang, Minglin Jin, Bin Fan, Jin Huang, Q Wang, Gao Z   +7 more
openalex   +1 more source

How Can Pharmacology Help Us Overcome the Challenges of Drug Repositioning as Antivirals to Treat Emerging Pathogens? The Example of Covid‐19

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
Pharmacological pitfalls and challenges in drug repurposing for emerging pathogens: lessons from COVID‐19. ABSTRACT The Covid‐19 pandemic highlighted the urgent need for effective therapies against emerging pathogens. Drug repurposing, defined as the use of existing medications for new therapeutic purposes, was extensively pursued for SARS‐CoV‐2 but ...
Inès Ben Ghezala, Nathan Peiffer‐Smadja, Caroline Solas, Antoine Nougairède, Franck Touret, Marc Bardou   +5 more
wiley   +1 more source

SYNCAS‐mediated CRISPR‐Cas9 genome editing in the Jewel wasp, Nasonia vitripennis

Insect Molecular Biology, Volume 35, Issue 1, Page 48-55, February 2026.
Maternal injection of Cas9 RNP together with BAPC and saponins (SYNCAS) results in efficient gene editing of Nasonia vitripennis offspring. The timing of injection and egg collection is important for maximising efficiency and reducing screening effort.
Filippo Guerra, Sander De Rouck, Eveline C. Verhulst   +2 more
wiley   +1 more source

Corrigendum to “Plasma membrane depolarization reveals endosomal escape incapacity of cell-penetrating peptides” [Eur. J. Pharm. Biopharm. 184 (2023) 13949]

Marc Serulla, Palapuravan Anees, Ali Hallaj, Evgeniya Trofimenko, Tara Kalia, Yamuna Krishnan, Christian Widmann   +6 more
openalex   +1 more source