Results 281 to 290 of about 47,261 (313)

Host cell potassium ion channels KCNJ2 (K _IR 2.1), KCNJ13 (K _IR 7.1) and KCNMA1 (BK _Ca ) mediate escape of Bunyamwera virus from late endosomal compartments

Hayley Pearson, Samantha Hover, Eleanor JAA Todd, Kyriakoulla Panayi, M. Stacey, Jamel Mankouri, Nigel A. Brown, Eric W. Hewitt, John N. Barr   +8 more
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Efficient Delivery of Curcumin by Functional Solid Lipid Nanoparticles with Promoting Endosomal Escape and Liver Targeting Properties

Ju Liang, Mingjie Zhang, Ying Liang, Xuening Li, Wen‐Lan Wu   +4 more
openalex   +1 more source

Development of histidine-modified gene carriers for improving transfection via enhanced endosomal escape

, 2010
Kai‐Ling Chang
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Monitoring endosomal escape of fluorescent cell-penetrating peptides

European Journal of Pharmaceutical Sciences
Ali Hallaj, Gwenaël Labouèbe, Virginie Mansuy-Aubert, Evgeniya Trofimenko, Christian Widmann   +4 more
openaire   +1 more source

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Unravelling the endosomal escape of pH-responsive nanoparticles using the split luciferase endosomal escape quantification assay

Biomaterials Science
Our work demonstrates the adaptation of a highly versatile split-luciferase endosomal escape quantification (SLEEQ) assay to better understand the endosomal escape efficiency of pH-responsive nanoparticles by tuning the HiBiT linker chemistry.
Umeka Nayanathara, Fan Yang, Changhe Zhang, Yufu Wang, Bruna Rossi Herling, Samuel A. Smith, Maximilian A. Beach, Angus P. R. Johnston, Georgina K. Such   +8 more
openaire   +3 more sources

Core mission: mRNA endosomal escape

Nature Reviews Chemistry
Sihan Xiong, Chuang Liu
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siRNA Vehicles for High Endosomal Escapability

2021
Small interfering RNA (siRNA) is a novel therapeutic modality for the treatment of intractable diseases; however, the development of a useful siRNA delivery vector is imperative for clinical use. Since siRNA works in the cytoplasm, the ability of the carrier to escape destruction in the endosomes is a highly required characteristic for the induction of
Hiroyuki, Koide, Sei, Yonezawa, Tomohiro, Asai   +2 more
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Endosomal escape pathways for delivery of biologicals

Journal of Controlled Release, 2011
Despite continuous improvements in delivery systems, the development of methods for efficient and specific delivery of targeted therapeutic agents still remains an issue in biological treatments such as protein and gene therapy. The endocytic pathway is the major uptake mechanism of cells and any biological agents, such as DNA, siRNA and proteins ...
Varkouhi, A.K., Scholte, M., Storm, G., Haisma, H.J.   +3 more
openaire   +5 more sources

Engineered Histidine-Rich Peptides Enhance Endosomal Escape for Antibody-Targeted Intracellular Delivery of Functional Proteins.

Angewandte Chemie, 2023
Currently, the clinical application of protein/peptide therapeutics is mainly limited to the modulation of diseases in extracellular spaces. Intracellular targets are hardly accessed, owing largely to the endosomal entrapment of internalized proteins ...
Yan Zhao, Haolin Jiang, Jiazhen Yu, Luyao Wang, Juanjuan Du   +4 more
semanticscholar   +1 more source

Endosomal Escape: A Bottleneck in Intracellular Delivery

Journal of Nanoscience and Nanotechnology, 2014
With advances in therapeutic science, apart from drugs, newer bioactive moieties like oligonucleotides, proteins, peptides, enzymes and antibodies are constantly being introduced for the betterment of therapeutic efficacy. These moieties have intracellular components of the cells like cytoplasm and nucleus as one of their pharmacological sites for ...
Harshad K, Shete, Rashmi H, Prabhu, Vandana B, Patravale   +2 more
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