Results 71 to 80 of about 47,261 (313)
Carbohydrate Polymers, 2023 This study aimed to evaluate the effect of thiolated α-cyclodextrin (α-CD-SH) on the cellular uptake of its payload. For this purpose, α-CD was thiolated using phosphorous pentasulfide.
Özlem Kaplan +6 more
semanticscholar +1 more source
Fluorescent labeling of plasmid DNA and mRNA : gains and losses of current labeling strategies [PDF]
, 2016 Live-cell imaging has provided the life sciences with insights into the cell biology and dynamics. Fluorescent labeling of target molecules proves to be indispensable in this regard. In this Review, we focus on the current fluorescent labeling strategies
Rombouts, Koen +2 more
core +1 more source
Breaking down the barriers: siRNA delivery and endosome escape [PDF]
Journal of Cell Science, 2010 RNA interference (RNAi)-based technologies offer an attractive strategy for the sequence-specific silencing of disease-causing genes. The application of small interfering (si)RNAs as potential therapeutic agents requires safe and effective methods for their delivery to the cytoplasm of the target cells and tissues. Recent studies have shown significant
Monika, Dominska, Derek M, Dykxhoorn
openaire +2 more sources
Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery
Research, 2023 Nanocarriers have therapeutic potential to facilitate drug delivery, including biological agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by several factors; among which, endosomal/lysosomal degradation after ...
Chong Qiu +10 more
doaj +1 more source
Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging [PDF]
, 2006 Small interfering RNA (siRNA) molecules are potent effectors of post-transcriptional gene silencing. Using noninvasive bioluminescent imaging and a mathematical model of siRNA delivery and function, the effects of target-specific and treatment-specific ...
Bartlett, Derek W., Davis, Mark E.
core +1 more source
Molecular Therapy: Nucleic Acids, 2021 DNA/RNA heteroduplex oligonucleotide (HDO), composed of DNA/locked nucleic acid (LNA) antisense oligonucleotide (ASO) and complementary RNA, is a next-generation antisense therapeutic agent.
Daisuke Ono +6 more
doaj +1 more source
Nanomaterials, 2021 Targeted tumor therapy can provide the basis for the inhibition of tumor growth. However, a number of toxin-based therapeutics lack efficacy because of insufficient endosomal escape after being internalized by endocytosis.
Ajmal Zarinwall +6 more
doaj +1 more source
Pharmacological Research, 2023 Extracellular vesicles hold great promise as a drug delivery platform for RNA-based therapeutics. However, there is a lack of experimental evidence for the intracellular trafficking of nucleic acid cargos, specifically, whether they are capable of ...
T. Thach +5 more
semanticscholar +1 more source
pH-triggered endosomal escape of pore-forming Listeriolysin O toxin-coated gold nanoparticles
Journal of Nanobiotechnology, 2019 Background A major bottleneck in drug delivery is the breakdown and degradation of the delivery system through the endosomal/lysosomal network of the host cell, hampering the correct delivery of the drug of interest.
Ismael Plaza-GA +8 more
doaj +1 more source
Novel approaches in development of cell penetrating peptides
Journal of Applied Pharmaceutical Research, 2021 Therapeutic cargos which are impermeable to the cell can be delivered by cell penetrating peptides (CPPs). CPP-cargo complexes accumulate by endocytosis inside the cells but they fail to reach the cytosolic space properly as they are often trapped in the
Vatsal R. Shah +2 more
doaj +1 more source