Results 251 to 260 of about 144,544 (285)

Activated microglial exosomes enhance α-Synuclein internalization and accelerate neurodegeneration in lewy body dementia. [PDF]

open access: yesJ Nanobiotechnology
Zhang M   +10 more
europepmc   +1 more source
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Endosome–lysosome fusion

Biochemical Society Transactions, 2010
The delivery of endocytosed cargo to lysosomes occurs through kissing and direct fusion of late endosomes/MVBs (multivesicular bodies) and lysosomes. Live-cell and electron microscopy experiments together with cell-free assays have allowed us to describe the characteristics of the delivery process and determine the core protein machinery required for ...
J Paul, Luzio   +2 more
openaire   +2 more sources

Late endosomes derive from early endosomes by maturation

Cell, 1991
Endocytosed proteins destined for degradation in lysosomes are targeted mainly to early endosomes following uptake. Late endosomes are the major site for entry of newly synthesized lysosomal hydrolases via the cation-independent mannose 6-phosphate receptor into the degradative pathway. No consensus exists as to the mechanism of transport from early to
Stoorvogel, W   +4 more
openaire   +3 more sources

Endosomal and non-endosomal functions of ESCRT proteins

Trends in Cell Biology, 2006
The three endosomal sorting complexes required for transport (ESCRTs) are integral to the degradation of endocytosed membrane proteins and multivesicular body (MVB) biogenesis. Here, we review evidence that ESCRTs have evolved as a specialized machinery for the degradative sorting of ubiquitinated membrane proteins and we highlight recent studies that ...
Thomas, Slagsvold   +3 more
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Endosomal system of Paramecium: coated pits to early endosomes

Journal of Cell Science, 1992
ABSTRACT A detailed morphological and tracer study of endocytosis via coated pits in Paramecium multimicronucleatum was undertaken to compare endocytic processes in a free-living protozoon with similar processes in higher organisms. Permanent pits at the cell surface enlarge, become coated and give rise to coated vesicles (188±41 nm in ...
R D, Allen, C C, Schroeder, A K, Fok
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Plant signaling endosomes and endosome trafficking

Russian Journal of Plant Physiology, 2010
A discovery of a possibility for signal transduction from endosomes differing quantitatively and qualitatively from signaling from the plasma membrane became a reliably proved fact for animal and yeast receptors but was unaddressed by plant researches for a long time.
openaire   +1 more source

The endosomal network

Int. Journal of Clinical Pharmacology and Therapeutics, 2009
Endocytosis is the process by which extracellular molecules are captured by the cell surface membrane and then taken up into the cell. Once inside the cell, the internalized material is delivered to its final destination via a complex system of organelles, termed the endosomal network.
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