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Correction for Pang et al., Structural elucidation of how ARF small GTPases induce membrane tubulation for vesicle fission. [PDF]
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Does GLUT4 Queue? A Mechanistic Mathematical Model for Insulin Response in Adipocytes. [PDF]
Sherlock BD +3 more
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Activated microglial exosomes enhance α-Synuclein internalization and accelerate neurodegeneration in lewy body dementia. [PDF]
Zhang M +10 more
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Active fluctuations of cytoplasmic actomyosin networks facilitate dynein-driven transport. [PDF]
Torisawa T, Saito K, Furuta K, Kimura A.
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Biochemical Society Transactions, 2010
The delivery of endocytosed cargo to lysosomes occurs through kissing and direct fusion of late endosomes/MVBs (multivesicular bodies) and lysosomes. Live-cell and electron microscopy experiments together with cell-free assays have allowed us to describe the characteristics of the delivery process and determine the core protein machinery required for ...
J Paul, Luzio +2 more
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The delivery of endocytosed cargo to lysosomes occurs through kissing and direct fusion of late endosomes/MVBs (multivesicular bodies) and lysosomes. Live-cell and electron microscopy experiments together with cell-free assays have allowed us to describe the characteristics of the delivery process and determine the core protein machinery required for ...
J Paul, Luzio +2 more
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Late endosomes derive from early endosomes by maturation
Cell, 1991Endocytosed proteins destined for degradation in lysosomes are targeted mainly to early endosomes following uptake. Late endosomes are the major site for entry of newly synthesized lysosomal hydrolases via the cation-independent mannose 6-phosphate receptor into the degradative pathway. No consensus exists as to the mechanism of transport from early to
Stoorvogel, W +4 more
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Endosomal and non-endosomal functions of ESCRT proteins
Trends in Cell Biology, 2006The three endosomal sorting complexes required for transport (ESCRTs) are integral to the degradation of endocytosed membrane proteins and multivesicular body (MVB) biogenesis. Here, we review evidence that ESCRTs have evolved as a specialized machinery for the degradative sorting of ubiquitinated membrane proteins and we highlight recent studies that ...
Thomas, Slagsvold +3 more
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Endosomal system of Paramecium: coated pits to early endosomes
Journal of Cell Science, 1992ABSTRACT A detailed morphological and tracer study of endocytosis via coated pits in Paramecium multimicronucleatum was undertaken to compare endocytic processes in a free-living protozoon with similar processes in higher organisms. Permanent pits at the cell surface enlarge, become coated and give rise to coated vesicles (188±41 nm in ...
R D, Allen, C C, Schroeder, A K, Fok
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Plant signaling endosomes and endosome trafficking
Russian Journal of Plant Physiology, 2010A discovery of a possibility for signal transduction from endosomes differing quantitatively and qualitatively from signaling from the plasma membrane became a reliably proved fact for animal and yeast receptors but was unaddressed by plant researches for a long time.
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Int. Journal of Clinical Pharmacology and Therapeutics, 2009
Endocytosis is the process by which extracellular molecules are captured by the cell surface membrane and then taken up into the cell. Once inside the cell, the internalized material is delivered to its final destination via a complex system of organelles, termed the endosomal network.
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Endocytosis is the process by which extracellular molecules are captured by the cell surface membrane and then taken up into the cell. Once inside the cell, the internalized material is delivered to its final destination via a complex system of organelles, termed the endosomal network.
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