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The Endosomal Network: Mediators and Regulators of Endosome Maturation

2018
Endocytosis is a means for the cell to sample its environment for nutrients and regulate plasma membrane (PM) composition and area. Whereas the majority of internalized cargo is recycled back to the cell surface, select material is sent to the lysosome for degradation.
Podinovskaia, Maria, Spang, Anne
openaire   +3 more sources

Endosomes, receptors, and viruses

Science, 2022
Mechanisms of infection are deciphered at the host-pathogen ...
openaire   +2 more sources

Repeated ER–endosome contacts promote endosome translocation and neurite outgrowth

Nature, 2015
The main organelles of the secretory and endocytic pathways--the endoplasmic reticulum (ER) and endosomes, respectively--are connected through contact sites whose numbers increase as endosomes mature. One function of such sites is to enable dephosphorylation of the cytosolic tails of endosomal signalling receptors by an ER-associated phosphatase ...
Raiborg, Camilla   +11 more
openaire   +3 more sources

Endosomal Functions in Plants

Traffic, 2008
Plant endosomes are highly dynamic organelles that are involved in the constitutive recycling of plasma membrane cargo and the trafficking of polarized plasma membrane proteins such as auxin carriers. In addition, recent studies have shown that surface receptors such as the plant defense‐related FLS2 receptor and the brassinosteroid receptor BRI1 ...
Marisa S, Otegui, Christoph, Spitzer
openaire   +2 more sources

Signaling Endosomes

Science Signaling, 2001
When neurotrophin receptors at the axon terminal are activated by their cognate ligands, signals are propagated to the neuronal cell body to regulate survival and differentiation. It has been thought that retrograde transport of endocytic vesicles containing such receptor-ligand complexes transmit these signals. Howe et al.
openaire   +2 more sources

Plant endosomal trafficking pathways

Current Opinion in Plant Biology, 2011
Endosomes regulate both the recycling and degradation of plasma membrane (PM) proteins, thereby modulating many cellular responses triggered at the cell surface. Endosomes also play a role in the biosynthetic pathway by taking proteins to the vacuole and recycling vacuolar cargo receptors.
Francisca C, Reyes   +2 more
openaire   +2 more sources

Endosomal Signaling and Oncogenesis

2014
The endosomal system provides a route whereby nutrients, viruses, and receptors are internalized. During the course of endocytosis, activated receptors can accumulate within endosomal structures and certain signal-transducing molecules can be recruited to endosomal membranes.
Engedal, Nikolai, Mills, Ian G
openaire   +3 more sources

Endosomes

Trends in Biochemical Sciences, 1983
Ari Helenius   +3 more
openaire   +1 more source

Endosome Fusion

2008
Brandhorst, D., Jahn, R.
openaire   +2 more sources

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