Results 121 to 130 of about 107,252 (310)

Visualization of endogenous G proteins on endosomes and other organelles

eLife
Classical G-protein-coupled receptor (GPCR) signaling takes place in response to extracellular stimuli and involves receptors and heterotrimeric G proteins located at the plasma membrane. It has recently been established that GPCR signaling can also take
Wonjo Jang, Kanishka Senarath, Gavin Feinberg, Sumin Lu, Nevin A Lambert   +4 more
doaj   +1 more source

siSGK1 increased the amount of wt-CFTR in early endosomes, but not in recycling endosomes.

, 2014
Co-immunoprecipitation studies were conducted to determine the subcellular location of wt-CFTR in siNeg and siSGK1 transfected cells treated with dexamethasone (50 nM for 4 hours).
M. Christine Chapline (526071), Bruce A. Stanton (226728), Jennifer M. Bomberger (226715), Bonita A. Coutermarsh (265103), J. Denry Sato (526070), Roxanna L. Barnaby (226726)   +5 more
core   +1 more source

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Loss of SynDIG4/PRRT1 alters distribution of AMPA receptors in Rab4- and Rab11-positive endosomes and impairs basal AMPA receptor recycling

Frontiers in Pharmacology
The transmembrane protein Synapse Differentiation Induced Gene 4 (SynDIG4) functions as an auxiliary factor of AMPA receptors (AMPARs) and plays a critical role in excitatory synaptic plasticity as well as hippocampal-dependent learning and memory.
Chun-Wei He, Elva Díaz
doaj   +1 more source

On the fate of early endosomes

bchm, 2009
Abstract Proteins are endocytosed by various pathways into the cell. All these pathways converge at the level of the early endosome. The fate of the early endosome and how proteins are sorted into recycling and late endosomes/multi-vesicular body is a matter of debate and intense research.
openaire   +5 more sources

RAB22A sorts epithelial growth factor receptor (EGFR) from early endosomes to recycling endosomes for microvesicles release

Microvesicles (MVs) containing proteins, nucleic acid or organelles are shed from the plasma membrane. Although the mechanisms of MV budding are well elucidated, the connection between endosomal trafficking and MV formation remains poorly understood.
Xia Zhang, Jingxuan Wang, Ruhua Zhang, Ying Gao, Tiebang Kang, Denghui Wei, Xiaobo He, Yujie Lin, Lanqing Huo, Yuanzhong Wu   +9 more
core   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

On the role of VP3-PI3P interaction in birnavirus endosomal membrane targeting

eLife
Birnaviruses are a group of double-stranded RNA (dsRNA) viruses infecting birds, fish, and insects. Early endosomes (EE) constitute the platform for viral replication. Here, we study the mechanism of birnaviral targeting of EE membranes.
Flavia A Zanetti, Ignacio Fernandez, Eduard Baquero, Pablo Guardado-Calvo, Andres Ferrino-Iriarte, Sarah Dubois, Etienne Morel, Victoria Alfonso, Milton Osmar Aguilera, María E Celayes, Luis Mariano Polo, Laila Suhaiman, Vanesa V Galassi, Maria V Chiarpotti, Carolina Allende-Ballestero, Javier M Rodriguez, Jose R Castón, Diego Lijavetzky, Oscar Taboga, María I Colombo, Mario Del Pópolo, Félix A Rey, Laura Ruth Delgui   +22 more
doaj   +1 more source

Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture

, 2015
Lateral diffusion in the membrane and endosomal trafficking both contribute to the addition and removal of AMPA receptors (AMPARs) at postsynaptic sites.
Adrian, M, Wierenga, Corette J, Lukas C. Kapitein, Futai, Kensuke, Hoogenraad, Casper C, Adrian, Max, Corette J. Wierenga, Watanabe, Takuya, Cho, S, Kapitein, Lukas C, Sub Cell Biology, Joanna Lipka, Lipka, J, Watanabe, T, Sukhee Cho, Cho, Sukhee, da Silva, ME, Celbiologie, Philipp Schätzle, Marta Esteves da Silva, Esteves da Silva, Marta, Dep Biologie, Futai, K, Wierenga, CJ, Kapitein, Lukas C., Casper C. Hoogenraad, Hoogenraad, Casper C., Hoogenraad, CC, Max Adrian, Takuya Watanabe, Wierenga, Corette J., Schatzle, P, Kapitein, Lukas, Lipka, Joanna, Schätzle, Philipp, Kensuke Futai   +35 more
core   +1 more source

A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates

Advanced Science, EarlyView.
Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao, Yan Deng, Jianjian Han, Yong Xie, Kai Bao, Lixin Ma, Lilong Liu, Wuxiang Mao   +7 more
wiley   +1 more source