Results 121 to 130 of about 113,399 (298)

Acidification of rat liver lysosomes: quantitation and comparison with endosomes

, 1993
Both lysosomes and endosomes are acidified by an electrogenic proton pump, although studies in intact cells indicate that the steady-state internal pH (pHi) of lysosomes is more acid than that of endosomes.
R. W. Van Dyke
core   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Visualization of endogenous G proteins on endosomes and other organelles

eLife
Classical G-protein-coupled receptor (GPCR) signaling takes place in response to extracellular stimuli and involves receptors and heterotrimeric G proteins located at the plasma membrane. It has recently been established that GPCR signaling can also take
Wonjo Jang, Kanishka Senarath, Gavin Feinberg, Sumin Lu, Nevin A Lambert   +4 more
doaj   +1 more source

Association with early endosomes.

, 2013
(A) Early endosomes were prepared from BHK cells treated or not for 10 min with 0.05 or 1 mM H2O2 [39], and analyzed by western blotting. (B) Experiments were as in (A), but cells were transfected with Flag-TXNL1 or Flag-TXNL1C34,37S.
Jean Gruenberg (34140), Etienne Morel (35915), Valeria Cavalli (35916), Michela Felberbaum-Corti (35914), Francis Vilbois (35917)   +4 more
core   +1 more source

Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2‐Modulated Exosome Release

Advanced Science, EarlyView.
Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Bilun Jin, Shaojie Dong, Yue Jia, Zhao Xu, Peiqi Liu, Zhaojing Ding, Yuxin Liao, Rui Zou, Jinsong Hu, Bo Cheng, Lin Niu   +10 more
wiley   +1 more source

Loss of SynDIG4/PRRT1 alters distribution of AMPA receptors in Rab4- and Rab11-positive endosomes and impairs basal AMPA receptor recycling

Frontiers in Pharmacology
The transmembrane protein Synapse Differentiation Induced Gene 4 (SynDIG4) functions as an auxiliary factor of AMPA receptors (AMPARs) and plays a critical role in excitatory synaptic plasticity as well as hippocampal-dependent learning and memory.
Chun-Wei He, Elva Díaz
doaj   +1 more source

siSGK1 increased the amount of wt-CFTR in early endosomes, but not in recycling endosomes.

, 2014
Co-immunoprecipitation studies were conducted to determine the subcellular location of wt-CFTR in siNeg and siSGK1 transfected cells treated with dexamethasone (50 nM for 4 hours).
M. Christine Chapline (526071), Bruce A. Stanton (226728), Jennifer M. Bomberger (226715), Bonita A. Coutermarsh (265103), J. Denry Sato (526070), Roxanna L. Barnaby (226726)   +5 more
core   +1 more source

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

Advanced Science, EarlyView.
Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu, Dandan Kou, Xiao Xiao, Bingbing Bai, Caide Liu, Mengyao Wu, Yadan Shi, Mengdan Xu, Xiaoyi Cao, Haodi Qi, Shuhua Wu, Jianfeng Zeng, Mingyuan Gao   +12 more
wiley   +1 more source

On the role of VP3-PI3P interaction in birnavirus endosomal membrane targeting

eLife
Birnaviruses are a group of double-stranded RNA (dsRNA) viruses infecting birds, fish, and insects. Early endosomes (EE) constitute the platform for viral replication. Here, we study the mechanism of birnaviral targeting of EE membranes.
Flavia A Zanetti, Ignacio Fernandez, Eduard Baquero, Pablo Guardado-Calvo, Andres Ferrino-Iriarte, Sarah Dubois, Etienne Morel, Victoria Alfonso, Milton Osmar Aguilera, María E Celayes, Luis Mariano Polo, Laila Suhaiman, Vanesa V Galassi, Maria V Chiarpotti, Carolina Allende-Ballestero, Javier M Rodriguez, Jose R Castón, Diego Lijavetzky, Oscar Taboga, María I Colombo, Mario Del Pópolo, Félix A Rey, Laura Ruth Delgui   +22 more
doaj   +1 more source

RAB22A sorts epithelial growth factor receptor (EGFR) from early endosomes to recycling endosomes for microvesicles release

Microvesicles (MVs) containing proteins, nucleic acid or organelles are shed from the plasma membrane. Although the mechanisms of MV budding are well elucidated, the connection between endosomal trafficking and MV formation remains poorly understood.
Xia Zhang, Jingxuan Wang, Ruhua Zhang, Ying Gao, Tiebang Kang, Denghui Wei, Xiaobo He, Yujie Lin, Lanqing Huo, Yuanzhong Wu   +9 more
core   +1 more source