Results 131 to 140 of about 107,252 (310)
CellsIntracellular cargo delivery via distinct transport routes relies on vesicle carriers. A key trafficking route distributes cargo taken up by clathrin-mediated endocytosis (CME) via early endosomes.
Hafiza Nosheen Saleem +5 more
doaj +1 more source
Removal of hypersignaling endosomes by simaphagy
Activated transmembrane receptors continue to signal following endocytosis and are only silenced upon ESCRT-mediated internalization of the receptors into intralumenal vesicles (ILVs) of the endosomes.
Raiborg, Camilla, +19 more
core +1 more source
Microautophagy of Cytosolic Proteins by Late Endosomes
, 2011 SummaryAutophagy delivers cytosolic components to lysosomes for their degradation. The delivery of autophagic cargo to late endosomes for complete or partial degradation has also been described. In this report we present evidence that distinct autophagic
E.S. Cannizzo +29 more
core +1 more source
Co-translational targeting of transcripts to endosomes
, 2020 Asymmetric localization and translation of mRNAs is used by single cells to sense their environment and integrate extrinsic cues with the appropriate cellular response.
Popovic, D (via Mendeley Data)
core +1 more source
Oligopeptides/DNA Coacervate Droplets as Macromolecular Delivery Microcarriers
Advanced Science, EarlyView.Oligopeptide–DNA coacervates formed via liquid–liquid phase separation serve as programmable carriers for macromolecular cargos, entering cells through lipid raft–associated pathways and subsequently undergoing enzyme triggered intracellular disassembly driven by DNA degradation processes, thereby enabling efficient, controlled, and spatially defined ...
Linyi Zhang +5 more
wiley +1 more source
Signaling endosomes: seeing is believing.
, 2010 Signaling compartmentalization provides a highly refined mechanism to specify context-dependent cellular responses. Endosomes are an intracellular membrane-bound compartment that mediates the transport of receptor-bound signaling complexes.
Bar-Sagi, Dafna, Miaczynska, Marta
core
Endosomes Labeled with Two Markers Show Presence of Rab7 in Early Endosomes
, 2013 Vero cells were fixed and viewed by confocal microscopy. (A) Confocal microscopy of immunolabeled cells using anti-EEA1 (green) and anti-Rab7 (red) antibodies, (B–F) The cells were transfected with fluorescent-protein-labeled ...
Andreas Vonderheit (124) +1 more
core +1 more source
Advanced Science, EarlyView.A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang +10 more
wiley +1 more source
ET indicates HDL-containing endosomes.
, 2013 A) shows a virtual slice, B) a corresponding model with endosomes (bright blue color) are accumulated in close proximity to the Golgi apparatus (orange color). (Scale bar: A, B = 200 µm).
Kaemisa Srisen (503497) +6 more
core +1 more source
MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes
Advanced Science, EarlyView.A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak +19 more
wiley +1 more source