Results 111 to 120 of about 113,399 (298)
Magnetic endosomes, probes inside living cells.
, 2013 Magnetic nanoparticles (black points on the electron micrograph, top left) concentrate within intracellular endosomes about 0.6 µm in diameter. Each endosome acquires a magnetic moment when submitted to a magnetic field B, resulting in the formation of ...
Thi-Hanh Nguyen (365851) +3 more
core +1 more source
Isolation of EGFR-containing early endosomes. [PDF]
, 2016 The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) that is an integral component of proliferative signaling. When activated by a ligand at the plasma membrane, EGFR undergoes clathrin-mediated endocytosis.
Gosney, Julie A.
core +1 more source
Advanced Science, EarlyView.An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu +11 more
wiley +1 more source
Relationship between endosomes and lysosomes
, 2001 Delivery of endocytosed macromolecules to lysosomes occurs by means of direct fusion of late endosomes with lysosomes. This has been formally demonstrated in a cell-free content mixing assay using late endosomes and lysosomes from rat liver.
Luzio, J. P. +5 more
core +1 more source
Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source
IRAP+ endosomes restrict TLR9 activation and signaling
, 2017 International audienceThe retention of intracellular Toll-like receptors (TLRs) in the endoplasmic reticulum prevents their activation under basal conditions. TLR9 is activated by sensing ligands in specific endosomal-lysosomal compartments.
Mauvais, Francois-Xavier +30 more
core +1 more source
Advanced Science, EarlyView.This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo +17 more
wiley +1 more source
The role of SARA1 Endosomes during neural precursor fate assignation
, 2012 Les endosomes SARA sont impliqués dans la ségrégation asymétrique des molécules Notch (Coumailleau, 2009). Pour savoir si ces caractéristiques étaient conservées dans le poisson zèbre, nous avons analysé les endosmes SARA dans le neuroépithélium : 1. Les
Kressmann, Sabine
core +1 more source
Advanced Science, EarlyView.In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu +7 more
wiley +1 more source
Sorting and recycling endosomes
, 2015 Sorting and Recycling Endosomes provides the latest information on endosomes, the receiving compartment for endocytosed cargos, and the donor compartment and sorting station for cargos designated to lysosomes, Golgi, or plasma membrane.
Guo, Wei
core