Results 341 to 350 of about 185,575 (398)

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Exosome Tethering Requires Tetherin Homodimerisation. [PDF]

Biol Cell
Yıldızhan Y, Bourke AM, Jackson HK, Manna PT, Palmulli R, Edgar JR.   +5 more
europepmc   +1 more source

Lung organoids as a human system for Mycobacteria infection modeling and drug testing

The FEBS Journal, EarlyView.
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Stephen Adonai Leon‐Icaza, Romain Vergé, Raoul Mazars, Laurence Berry, Céline Cougoule   +4 more
wiley   +1 more source

Organelle stress in NLRP3 inflammasome: a central mediator of neurodegenerative diseases. [PDF]

Mol Neurodegener
Jia H, Ma L, Liu J, Gao M, Liang X, Zhang F, Gao Y, Liu M, Jiang W, Wei M, Zhong X.   +10 more
europepmc   +1 more source

Label‐free imaging of intracellular structures in living mammalian cells via external apodization phase‐contrast microscopy

The FEBS Journal, EarlyView.
External apodization phase‐contrast (ExAPC) microscopy enables label‐free visualization of diverse intracellular structures in living mammalian cells. By enhancing phase‐contrast imaging through optical apodization, ExAPC reveals fine subcellular details, such as lipid droplets and organelle contacts, without fluorescent labels.
Hiroshi Ohno, Takenori Nishimura, Kenta Kainoh, Yoshitaka Ohashi, Naoko Onodera, Mayuko Kano, Lay Nurhana Sari, Masato Masuda, Yoshiaki Tamura, Teppei Nishino, Yusuke Hayashi, Yusuke Yamamoto, Shin‐Ichiro Takahashi, Yuta Mishima, Yosuke Yoneyama, Yoshinori Takeuchi, Motohiro Sekiya, Takashi Matsuzaka, Takafumi Miyamoto, Hitoshi Shimano   +19 more
wiley   +1 more source

SNX16 aggravates AngII-induced cardiac hypertrophy in mice via EGFR transactivation. [PDF]

Commun Biol
Xie L, Wen K, Yu GH, Li X, Zeng YY, Qiao XH, Lu BQ, Chen L, Wang XL, He J, Lin YJ, Ren XY, Wu X, Yang QK, Hu LL, Ji Y, Xin HB, Deng KY.   +17 more
europepmc   +1 more source

The free-living ciliate Tetrahymena pyriformis inactivates engulfed influenza A(H1N1)pdm09 virus via two distinct types of endosomes. [PDF]

Sci Rep
Pushkareva VI, Krepkaia AS, Ignatieva AV, Shevlyagina NV, Andreevskaya SG, Fofanova E, Sysolyatina EV, Zhukhovitsky VG, Burtseva EI, Ermolaeva SA.   +9 more
europepmc   +1 more source

p62 sorts Lupus La and selected microRNAs into breast cancer-derived exosomes. [PDF]

J Cell Biol
Ngo JM, Williams JK, Temoche-Diaz MM, Murugupandiyan A, Schekman R.   +4 more
europepmc   +1 more source

Shaping the Immune Response: Cathepsins in Virus-Dendritic Cell Interactions. [PDF]

Cells
Niedzielska A, Bossowska-Nowicka M, Biernacka Z, Gregorczyk-Zboroch K, Toka FN, Szulc-Dąbrowska L.   +5 more
europepmc   +1 more source

Ultrastructural effects of learning and post-learning sleep on the dorsal striatum. [PDF]

Sleep
Squarcio F, Loschky SS, Nagai H, Spano GM, Marshall W, Tononi G, Cirelli C.   +6 more
europepmc   +1 more source