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Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions. [PDF]

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Jiang S, Fu J, Li S, Li Z, Zhao Q, Yin Y, Yang M, Wang Y.   +7 more
europepmc   +1 more source

HOPS disruption impairs APP trafficking and processing, promoting exosomal secretion of APP-CTFs

Draper D, George AE, Veenendaal T, Dijk Sv, Verweij FJ, Klumperman J, Farías GG.   +6 more
europepmc   +1 more source

CNTF specifically slows down the axonal transport of signalling endosomes

Rhymes ER, Sleigh JN, Schiavo G, Tosolini AP.   +3 more
europepmc   +1 more source

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Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

Science, 2008
Katarina Trajkovic, Chieh Hsu, Salvatore Chiantia   +2 more
exaly   +2 more sources

Endosomes are specialized platforms for bacterial sensing and NOD2 signalling

Nature, 2014
Ann De Mazière, Judith Klumperman, Ira Mellman   +2 more
exaly   +2 more sources

Endosome–lysosome fusion

Biochemical Society Transactions, 2010
The delivery of endocytosed cargo to lysosomes occurs through kissing and direct fusion of late endosomes/MVBs (multivesicular bodies) and lysosomes. Live-cell and electron microscopy experiments together with cell-free assays have allowed us to describe the characteristics of the delivery process and determine the core protein machinery required for ...
J Paul, Luzio, Sally R, Gray, Nicholas A, Bright   +2 more
openaire   +2 more sources

Late endosomes derive from early endosomes by maturation

Cell, 1991
Endocytosed proteins destined for degradation in lysosomes are targeted mainly to early endosomes following uptake. Late endosomes are the major site for entry of newly synthesized lysosomal hydrolases via the cation-independent mannose 6-phosphate receptor into the degradative pathway. No consensus exists as to the mechanism of transport from early to
Stoorvogel, W, Strous, G J, Geuze, H J, Oorschot, V, Schwartz, A L   +4 more
openaire   +3 more sources

Endosomal and non-endosomal functions of ESCRT proteins

Trends in Cell Biology, 2006
The three endosomal sorting complexes required for transport (ESCRTs) are integral to the degradation of endocytosed membrane proteins and multivesicular body (MVB) biogenesis. Here, we review evidence that ESCRTs have evolved as a specialized machinery for the degradative sorting of ubiquitinated membrane proteins and we highlight recent studies that ...
Thomas, Slagsvold, Krupa, Pattni, Lene, Malerød, Harald, Stenmark   +3 more
openaire   +2 more sources