Results 71 to 80 of about 15,277 (204)

Thyroid status modulates T lymphoma growth via cell cycle regulatory proteins and angiogenesis [PDF]

, 2014
We have shown in vitro that thyroid hormones (THs) regulate the balance between proliferation and apoptosis of T lymphoma cells. The effects of THs on tumor development have been studied, but the results are still controversial.
Barreiro Arcos, María Laura, Cayrol, Maria Florencia, Colombo, L., Cremaschi, Graciela Alicia, Díaz Flaqué, María Celeste, Klecha, Alicia Juana, Martinel Lamas, Diego José, Medina, Vanina Araceli, Paulazo, Maria Alejandra, Sterle, Helena Andrea, Valli, Eduardo   +10 more
core   +1 more source

Unraveling the mysteries of endostatin [PDF]

IUBMB Life, 2009
AbstractEndostatin, a 20‐kDa C‐terminal proteolytic fragment of collagen XVIII, is a specific endogenous angiogenesis inhibitor discovered more than a decade. The structure, stability, and mechanism of actions of endostatin have been extensively investigated during the past 12 years, among which controversial reports remain unclarified.
Yan, Fu, Huadong, Tang, Yujie, Huang, Nan, Song, Yongzhang, Luo   +4 more
openaire   +2 more sources

Effects of Rh-endostar in Combination with Radiotherapy on Rats with Lung Cancer [PDF]

, 2010
Background and objective Radiation sensitivity is closely related to tissue oxygen, and rh-endostatin can induce the high level of oxygen content in tumor by "normalizing" tumor angiogenesis which is associated with radiotherapy sensitivity.
Changhu LI, Du HE, Fang YANG, Wei GE, Ximin XU, Zhenyu ZHAO   +5 more
core  

Linking Antibody Fc Domain to Endostatin Significantly Improves Endostatin Half-life and Efficacy [PDF]

Clinical Cancer Research, 2008
Abstract Purpose: The half-life of the antiangiogenic molecule endostatin that has been used in clinical trial is short (∼2 h). In addition, ∼50% of the clinical grade endostatin molecules lack four amino acids at their NH2 termini. Lack of these amino acids gives rise to a molecule that is devoid of zinc, resulting in no antitumor ...
Tong-Young, Lee, Robert M, Tjin Tham Sjin, Shahla, Movahedi, Bissan, Ahmed, Elke A, Pravda, Kin-Ming, Lo, Stephen D, Gillies, Judah, Folkman, Kashi, Javaherian   +8 more
openaire   +2 more sources

Cardiac Angiosarcoma With Lung Metastasis Presenting as Granuloma‐Like Lesions: One Case Report and Literature Review

Respirology Case Reports, Volume 13, Issue 12, December 2025.
In this report, we present a case of a 30‐year‐old female who initially presented with recurrent hemoptysis and multiple pulmonary nodules with exudative changes in the lung, pathologically resembling granulomatous lesions and eventually confirmed as primary cardiac angiosarcoma with pulmonary metastasis.
Weiqi Mao, Xiaoyan Chen, Jian Xu, Liang Xie, Xu Wu, Lingli Chen, Yuanlin Song, Jun She   +7 more
wiley   +1 more source

Rh-endostatin Concomitant with Chemotherapy Versus Single Agent Chemotherapy for Treating Soft Tissue and Bone Sarcomas: A Systematic Review and Meta-Analysis

Journal of Pharmacy & Pharmaceutical Sciences, 2018
Objectives: Endostar (recombinant human endostatin (rh-endostatin)), a 20-kDa proteolytic fragment of collagen XVIII, was approved for the treatment of non–small cell lung cancer (NSCLC).
Zhuo Ma, Lifang Guo, Xiangli Cui, He Liu, Lihong Liu   +4 more
doaj   +1 more source

Study of Modern Control Methodologies Applied to Tumor Growth under Angiogenic Inhibition [PDF]

, 2014
Cancer treatment is one of the most important research fields of modern medicine. In the last decades, targeted molecular therapies showed pr osperous results. These treatments achieve tumor regression with limited side-effects. Mathem atical models
Angiogenic Inhibition, Annamária Szeles, Dániel A. Drexler, István Harmati, Johanna Sápi, Levente Kovács   +5 more
core   +1 more source

CD8+ T Cells Negatively Modulate Ischemia‐Induced Angiogenesis in Mice

The FASEB Journal, Volume 39, Issue 22, 30 November 2025.
Graphical illustration of the mechanism of CD8+ T‐cells/IFN‐γ axis‐mediated angiogenesis in response to ischemic stress. CD8+ T‐cell functions as an important mediator of ischemia‐induced angiogenesis via the modulation of inflammation, oxidative stress, proteolysis, and endothelial proliferation that might be mediated by the IFN‐γ/NLRp3‐caspase‐1 and ...
Xianji Piao, Jin Jingyuan, Longzhu Dai, Longguo Zhao, Yanglong Li, Megumi Narisawa, Shangzhi Shu, Yanna Lei, Xueling Yue, Jinshun Piao, Chengjie Zhu, Lina Hu, Qingsong Cui, Xian Wu Cheng   +13 more
wiley   +1 more source

Elevated endostatin is associated with hypertension treatment, elevated high sensitivity C-reactive protein, increased waist-hip ratio, and attenuated kidney function, but not with age, in a middle-aged population

Global Cardiology
Circulating endostatin has been linked to increased mortality, cardiovascular comorbidities, and renal impairment. However, its role as a cardiovascular risk marker in the general population remains largely unexplored.
Anders Larsson, Bertil Wegmann, Toralph Ruge, Joakim Alfredsson, Carl Johan Östgren, Tomas Lindahl   +5 more
doaj   +1 more source

E-M, an Engineered Endostatin with High ATPase Activity, Inhibits the Recruitment and Alternative Activation of Macrophages in Non-small Cell Lung Cancer

Frontiers in Pharmacology, 2017
Endostatin recently was reported by our laboratory to possess ATPase activity that is indispensable for its anti-angiogenesis and anti-tumor effects. An engineered endostatin, E-M, which owns higher ATPase activity exhibits stronger inhibitory effects on
Min Xu, Min Xu, Min Xu, Shaosen Zhang, Shaosen Zhang, Shaosen Zhang, Lin Jia, Lin Jia, Lin Jia, Shan Wang, Shan Wang, Shan Wang, Jie Liu, Jie Liu, Jie Liu, Xuhui Ma, Xuhui Ma, Xuhui Ma, Chunying Wang, Chunying Wang, Chunying Wang, Yan Fu, Yan Fu, Yan Fu, Yongzhang Luo, Yongzhang Luo, Yongzhang Luo   +26 more
doaj   +1 more source