Results 81 to 90 of about 15,277 (204)

Reciprocal interactions between tumor and endothelial cells: Effects of selective vasopressin V2 receptor peptide agonists [PDF]

, 2014
Recent experimental evidence suggested that the synthetic peptide desmopressin (DDAVP) interferes tumor angiogenesis by inducing the formation of angiostatin.
Alonso, Daniel Fernando, Garona, Juan
core   +1 more source

Cardiovascular Safety of VIAN‐c4551, an Antiangiogenic Peptide Derived From Vasoinhibin

Drug Development Research, Volume 86, Issue 7, November 2025.
ABSTRACT Vasoinhibin is a potent antiangiogenic protein that blocks the activation of endothelial nitric oxide synthase (eNOS) in response to vascular endothelial growth factor, bradykinin, and acetylcholine (ACh). In this regard, VIAN‐c4551, a new synthetic vasoinhibin analog, has therapeutic potential for targeting angiogenesis in oncology and ...
Miguel A. García‐González, Alejandro D. Miguel‐Martínez, Abimael González‐Hernández, Magdalena Zamora, Elva Adán‐Castro, Xarubet Ruíz‐Herrera, María A. Carbajo‐Mata, Jakob Triebel, Thomas Bertsch, José G. Lopez‐Lopez, Gonzalo Martínez de la Escalera, Juan Pablo Robles, Carmen Clapp, Carlos M. Villalón   +13 more
wiley   +1 more source

Difference in Serum Endostatin Levels in Diabetic Patients with Critical Limb Ischemia Treated by Autologous Cell Therapy or Percutaneous Transluminal Angioplasty

Cell Transplantation, 2018
The aim of this study was to compare the serum levels of the anti-angiogenic factor endostatin (S-endostatin) as a potential marker of vasculogenesis after autologous cell therapy (ACT) versus percutaneous transluminal angioplasty (PTA) in diabetic ...
Andrea Nemcova, Alexandra Jirkovska, Michal Dubsky, Libor Kolesar, Robert Bem, Vladimira Fejfarova, Anna Pysna, Veronika Woskova, Jelena Skibova, Edward B. Jude   +9 more
doaj   +1 more source

Immunomodulatory Mechanisms of Chronic Wound Healing: Translational and Clinical Relevance

MedComm, Volume 6, Issue 11, November 2025.
This graphical abstract illustrates the immunomodulation of chronic wounds through various therapeutic approaches aimed at regulating the immune response to promote healing. ABSTRACT Chronic wounds—such as diabetic foot ulcers (DFUs), pressure ulcers (PUs), and venous leg ulcers (VLUs)—pose a serious clinical challenge due to their prolonged ...
Mahrukh Riaz, Muhammad Zohaib Iqbal, Agnes S. Klar, Thomas Biedermann   +3 more
wiley   +1 more source

Numerical simulation of solid tumor blood perfusion and drug delivery during the “vascular normalization window” with antiangiogenic therapy [PDF]

, 2011
This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2011 Hindawi PublishingTo investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network ...
Cai, Y, Cao, J, Long, Q, Lv, J, Xu, S, Yao, W, Zhou, Y   +6 more
core   +2 more sources

Intracerebral Hemorrhage: Advances, Knowledge Gaps, and Future Directions

MedComm, Volume 6, Issue 11, November 2025.
This review provides a comprehensive synthesis of current research on the epidemiology, pathophysiological mechanisms, imaging characteristics, treatment delays, clinical management strategies, neural repair, and prognostic prediction of intracerebral hemorrhage (ICH).
Tao Liu, Weiwei Jiang, Minzhi Zhang, Shangzhi Xiong, Linan Chen, Xiaoying Chen, Rongcai Jiang   +6 more
wiley   +1 more source

Stimuli‐responsive systems: A focus on controlled drug delivery for posterior segment ocular disease

Responsive Materials, Volume 3, Issue 4, November 2025.
This review highlights recent advances in stimuli‐responsive drug delivery for posterior segment diseases, focusing on mechanisms and potential. It also explores mechanically interlocked molecules and bioorthogonal reactions as novel approaches. Challenges and future perspectives are discussed, aiming to bridge the gap between research and clinical ...
Chengzhi Zhang, Jiayi Hou, Yameng Zhao, Yiwen Wang, Kexin Wang, Siyu Li, Yange Wang, Jiehao Zhang, Shenao Ding, Chenxu Zhang, Zongming Song, Ye Tao   +11 more
wiley   +1 more source

Gene therapy of liver cancer [PDF]

, 2006
The application of gene transfer technologies to the treatment of cancer has led to the development of new experimental approaches like gene directed enzyme/pro-drug therapy (GDEPT), inhibition of oncogenes and restoration of tumor-suppressor genes.
Hernandez-Alcoceba, R. (Rubén), Prieto, J. (Jesús), Sangro, B. (Bruno)   +2 more
core   +1 more source

Endostatin for fibrosis [PDF]

Science-Business eXchange, 2012
University of Pittsburgh researchers have identified fibrosis as a potential new indication for the cancer therapeutic endostatin. The team designed a modified version of the peptide that reversed fibrosis in ex vivo human skin models and in mice.
openaire   +1 more source

Tumor Endothelial Cells Induce M2 Macrophage Polarization via IL‐4, Enhancing Tumor Growth in Hepatocellular Carcinoma

Cancer Science, Volume 116, Issue 11, Page 2972-2985, November 2025.
Tumor endothelial cells (TECs) promote the polarization of macrophages to M2 subtype by secreting IL‐4. Downregulation of IL‐4 in TECs suppressed M2 polarization and tumor progression. A high abundance of both TECs and M2 macrophages in HCC specimens is associated with poor prognosis.
Daijiro Matoba, Takehiro Noda, Shogo Kobayashi, Yoshihiro Sakano, Kenichi Matsumoto, Chihiro Yamanaka, Kazuki Sasaki, Shinichiro Hasegawa, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Hidenori Takahashi, Tadafumi Asaoka, Junzo Shimizu, Hisashi Wada, Yuichiro Doki, Hidetoshi Eguchi   +17 more
wiley   +1 more source