Results 221 to 230 of about 5,971,613 (303)

Identification of unannotated microproteins involved in endothelial cell homeostasis, dysfunction, and vascular disease. [PDF]

Cardiovasc Res
Siragusa M, Graumann J, Kuenne C, Günther S, Jeratsch S, Güven B, Süsser S, Talyan S, Bezuneh B, Matthess Y, Cartura M, Zhou X, Cho H, Sachs N, Maegdefessel L, Müller OJ, Troidl C, Nef HM, Looso M, Kaulich M, Offermanns S, Fleming I.   +21 more
europepmc   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Commentary: Anti-endothelial cell antibodies in pathogenesis of vasculitis. [PDF]

Front Immunol
Xie J, Shi L, Wang L, Dai J.
europepmc   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Imaging the therapeutic effects of cerebral endothelial cell derived exosome treatment of a preclinical model of Alzheimer's disease. [PDF]

Front Aging Neurosci
Li L, Ding G, Zhang L, Luo H, Boyd E, Li Q, Kaur J, Bohara M, Chopp M, Zhang ZG, Jiang Q.   +10 more
europepmc   +1 more source

Ethical Precision in Nanoscale Brain Interfacing

Advanced Science, EarlyView.
As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley   +1 more source

FURIN induces vascular endothelial cell death and efferocytosis through enzymatic cleavage of thrombospondin-1. [PDF]

J Physiol
Chen R, Shen D, Mahieux A, Song D, Wu S, Huang X, Yang X, Chen K, McVey DG, Liehn EA, Singaraja RR, Ye S.   +11 more
europepmc   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Sex differences in endothelial cell biology: cellular phenotypes and molecular regulators. [PDF]

Front Physiol
Pislaru A, Haas TL.
europepmc   +1 more source