Results 51 to 60 of about 971,647 (316)

Double-Stranded RNA Attenuates the Barrier Function of Human Pulmonary Artery Endothelial Cells

, 2013
Circulating RNA may result from excessive cell damage or acute viral infection and can interact with vascular endothelial cells. Despite the obvious clinical implications associated with the presence of circulating RNA, its pathological effects on ...
Heinemann, Akos, Zoltán Bálint, Akos Heinemann, György Váró (417636), Végh Attila G., Fazakas Csilla, Olschewski Horst, Csilla Fazakas, Krizbai István A., Wilhelm, Imola, Horst Olschewski, Heinemann Akos, Konya, Viktoria, Diana Zabini, Chandran Nagaraj, Nagaraj Chandran, Váró, György, Bálint Zoltán, Zoltán Bálint (142590), Zabini, Diana, György Váró, Andrea Olschewski, Csilla Fazakas (218764), Akos Heinemann (142582), Olschewski Andrea, Attila G Végh, Olschewski, Horst, Chandran Nagaraj (142558), Bálint, Zoltán, István A Krizbai, István A. Krizbai (218814), Imola Wilhelm (218768), Andrea Olschewski (142595), Fazakas, Csilla, Viktoria Konya, Diana Zabini (142555), Attila G. Végh (417635), Viktoria Konya (176778), Váró György, Krizbai, István Adorján, Wilhelm Imola, Horst Olschewski (142585), Zabini Diana, Konya Viktoria, Olschewski, Andrea, Végh, Attila Gergely, Imola Wilhelm   +46 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells.

PLoS ONE, 2014
The endothelial cell has a remarkable ability for sub-specialisation, adapted to the needs of a variety of vascular beds. The role of developmental programming versus the tissue contextual environment for this specialization is not well understood.
Mark Toshner, Benjamin J Dunmore, Eoin F McKinney, Mark Southwood, Paola Caruso, Paul D Upton, John P Waters, Mark L Ormiston, Jeremy N Skepper, Gerard Nash, Amer A Rana, Nicholas W Morrell   +11 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Mycolactone-dependent depletion of endothelial cell thrombomodulin is strongly associated with fibrin deposition in Buruli ulcer lesions [PDF]

, 2015
A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin mycolactone.
Simmonds, RE, Esmon Charles T., Gerd Pluschke, Alexander Stainer, Alexander Stainer (771266), Josefin Ahnström (771267), Vogel Moritz, Stainer Alexander, Wu, HL, Hua-Lin Wu (70210), Ruf, Marie-Thérèse, Pluschke, G, Belinda S. Hall, Vogel, Moritz, Ahnström Josefin, Simmonds Rachel E., Vogel, M, Hall Belinda S., Marie-Thérèse Ruf (2280196), Simmonds, Rachel E., Ogbechi Joy, Moritz Vogel, Moritz Vogel (267190), Hall, Belinda S., Stainer, Alexander, Behr, Marcel A., Katherine Bodman-Smith, Josefin Ahnström, Bodman-Smith, K, Esmon, Charles T., Ogbechi, J, Ahnström, J, Rachel E Simmonds, Charles T. Esmon, Pluschke, Gerd, Charles T Esmon, Wu, Hua-Lin, Joy Ogbechi (546561), Hua-Lin Wu, Charles T. Esmon (280612), Joy Ogbechi, Bodman-Smith Katherine, Marie-Thérèse Ruf, Esmon, CT, Katherine Bodman-Smith (771265), Belinda S. Hall (546558), Rachel E. Simmonds, Wu Hua-Lin, Ruf Marie-Thérèse, Pluschke Gerd, Ruf, MT, Ahnström, Josefin, Gerd Pluschke (7855), Ogbechi, Joy, Stainer, A, Belinda S Hall, Rachel E. Simmonds (546562), Bodman-Smith, Katherine, Hall, BS   +58 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Genetic variation is the major determinant of individual differences in leukocyte endothelial adhesion.

PLoS ONE, 2014
ObjectiveTo determine the genetic contribution to leukocyte endothelial adhesion.MethodsLeukocyte endothelial adhesion was assessed through a novel cell-based assay using human lymphoblastoid cell lines.
Michael A Grassi, Vidhya Rao, Kathryn P Winkler, Wei Zhang, Joseph D Bogaard, Siquan Chen, Bonnie LaCroix, Divya Lenkala, Jalees Rehman, Asrar B Malik, Nancy J Cox, R Stephanie Huang   +11 more
doaj   +1 more source

Endothelial cell-specific loss of eNOS differentially affects endothelial function.

PLoS ONE, 2022
The endothelium maintains and regulates vascular homeostasis mainly by balancing interplay between vasorelaxation and vasoconstriction via regulating Nitric Oxide (NO) availability.
Shuhan Bu, Hien C Nguyen, Sepideh Nikfarjam, David C R Michels, Berk Rasheed, Sauraish Maheshkumar, Shweta Singh, Krishna K Singh   +7 more
doaj   +1 more source

Uptake and cytotoxicity of citrate-coated gold nanospheres : comparative studies on human endothelial and epithelial cells [PDF]

, 2012
The use of gold nanoparticles (AuNPs) for diagnostic applications and for drug and gene-delivery is currently under intensive investigation. For such applications, biocompatibility and the absence of cytotoxicity of AuNPs is essential. Although generally
C Kirkpatrick, Romero, Ignacio, Kirkpatrick, C. James, Weksler Babette B, Uboldi, Chiara, Gibson, Matthew I.; id_orcid, Gibson, Matthew, Kirkpatrick, C. J. (C. James), Weksler, Babette B., Freese, Christian, Unger, Ronald E., Romero Ignacio A, Kirkpatrick, James, C., Couraud, Pierre-Olivier, Kirkpatrick C, Gibson, Matthew I., Babette B Weksler, Weksler, Babette, Kirkpatrick, James,, Pierre-Olivier Couraud, Gibson Matthew I, Kirkpatrick, C. J., Couraud Pierre-Olivier, Unger Ronald E, Chiara Uboldi, Matthew I Gibson, Ignacio A Romero, Unger, Ronald, Freese Christian, Ronald E Unger, Uboldi Chiara, Romero, Ignacio A., Christian Freese   +32 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source