Results 51 to 60 of about 5,971,613 (303)

Visualization of Endothelial Actin Cytoskeleton in the Mouse Retina [PDF]

, 2012
Angiogenesis requires coordinated changes in cell shape of endothelial cells (ECs), orchestrated by the actin cytoskeleton. The mechanisms that regulate this rearrangement in vivo are poorly understood - largely because of the difficulty to visualize ...
Aszodi, Attila, Emanuel Rognoni (124910), Rehberg, Markus, Montanez Eloi, Eloi Montanez (124926), Rognoni Emanuel, Franco, C.A., Emanuel Rognoni, Neto, F, Aszodi Attila, Neto, Filipa, Claudio A. Franco, Rehberg Markus, Alessia Fraccaroli, Fraccaroli Alessia, Gerhardt Holger, Gerhardt, H, Roland Wedlich-Söldner, Montanez, E., Rognoni, E., Montanez, E, Claudio A. Franco (124909), Wedlich-Söldner, Roland, Fraccaroli, A., Filipa, N., Franco Claudio A., Attila Aszodi, Gerhardt, Holger, Neto, F., Alessia Fraccaroli (124908), Holger Gerhardt (124923), Montanez, Eloi, Filipa Neto (124912), Fraccaroli, Alessia, Aszodi, A., Rognoni, E, Claudio A Franco, Filipa Neto, Franco, Claudio A., Wedlich-Söldner Roland, Ulrich Pohl (124920), Markus Rehberg, Pohl, U, Aszodi, A, Wedlich-Söldner, R., Neto Filipa, Pohl, U., Eloi Montanez, Pohl Ulrich, Franco, C., Wedlich-Söldner, R, Holger Gerhardt, Ulrich Pohl, Franco, CA, Pohl, Ulrich, Markus Rehberg (124914), Rehberg, M., Gerhardt, H., Roland Wedlich-Söldner (124918), Rognoni, Emanuel, Attila Aszodi (124916), Fraccaroli, A, Rehberg, M   +62 more
core   +2 more sources

Genetic variation is the major determinant of individual differences in leukocyte endothelial adhesion.

PLoS ONE, 2014
ObjectiveTo determine the genetic contribution to leukocyte endothelial adhesion.MethodsLeukocyte endothelial adhesion was assessed through a novel cell-based assay using human lymphoblastoid cell lines.
Michael A Grassi, Vidhya Rao, Kathryn P Winkler, Wei Zhang, Joseph D Bogaard, Siquan Chen, Bonnie LaCroix, Divya Lenkala, Jalees Rehman, Asrar B Malik, Nancy J Cox, R Stephanie Huang   +11 more
doaj   +1 more source

Endothelial cell-specific loss of eNOS differentially affects endothelial function.

PLoS ONE, 2022
The endothelium maintains and regulates vascular homeostasis mainly by balancing interplay between vasorelaxation and vasoconstriction via regulating Nitric Oxide (NO) availability.
Shuhan Bu, Hien C Nguyen, Sepideh Nikfarjam, David C R Michels, Berk Rasheed, Sauraish Maheshkumar, Shweta Singh, Krishna K Singh   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Peptide Bbeta(15-42) preserves endothelial barrier function in shock [PDF]

, 2009
Loss of vascular barrier function causes leak of fluid and proteins into tissues, extensive leak leads to shock and death. Barriers are largely formed by endothelial cell-cell contacts built up by VE-cadherin and are under the control of RhoGTPases. Here
George Ignatyev, Sonja Reingruber, Hofer-Warbinek, Renate, Ulrich Matt, Atrasheuskaya, Alena, Waltraud Pasteiner, Ignatyev, George, Gröger, Marion, Zacharowski, Kai, Reingruber, Sonja, Petzelbauer, Peter, Renate Hofer-Warbinek, Friedl, Peter, Zinkl, Daniela, Peter Petzelbauer, Pasteiner, Waltraud, Knapp, Sylvia, Alena Atrasheuskaya, Bukin, Eugenij, Eugenij Bukin, Matt, Ulrich, Kai Zacharowski, Sylvia Knapp, Peter Friedl, Marion Gröger, Daniela Zinkl   +25 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells [PDF]

, 2007
Interactions between leukocytes and vascular endothelial cells are mediated by a complex set of membrane adhesion molecules which transduce bi-directional signals in both cell types.
Laran-Chich, M.-P., Bourdoulous, S., Pierre-Olivier Couraud, John Greenwood, Leveque, M., Greenwood, J., Mathilde Leveque, Rampon, C., Couraud, P.-O., Jean-Pierre Couty, Christine Rampon, Marie-Pierre Laran-Chich, Couty, J.-P., Sandrine Bourdoulous   +13 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A multiscale hybrid model for pro-angiogenic calcium signals in a vascular endothelial cell [PDF]

, 2011
Cytosolic calcium machinery is one of the principal signaling mechanisms by which endothelial cells (ECs) respond to external stimuli during several biological processes, including vascular progression in both physiological and pathological conditions ...
Marco Scianna, Scianna, Marco
core   +1 more source

The role of endothelial junctions in the regulation of the extravasation of tumor cells. A historical reappraisal

Frontiers in Oncology
Endothelial cells lining the vessel wall are connected by adherent, tight and gap junctions. Adherent junctions are common to all endothelial cells, whereas tight and gap junctions graduate within different vascular segments.
Domenico Ribatti
doaj   +1 more source