Results 31 to 40 of about 444,778 (249)

Efficacy of manual small incision cataract surgery in preventing the endothelial cell loss

MRIMS Journal of Health Sciences, 2016
Background: Every year 5 million cataract surgeries are performed in India. Two major procedures are used to conduct cataract operations either MSICS/Phecoemulisfication. In both the procedures the loss of endothelial cells are observed.
P V Nanda Kumar Reddy, Sunisha, Atul Gupta   +2 more
doaj   +1 more source

Critical Role of Caveolin-1 Loss/Dysfunction in Pulmonary Hypertension

Medical Sciences, 2021
Pulmonary hypertension (PH) is a rare disease with a high morbidity and mortality rate. A number of systemic diseases and genetic mutations are known to lead to PH.
Rajamma Mathew
doaj   +1 more source

Study of corneal endothelial cell layer 3 months after Descemet membrane endothelial keratoplasty

Journal of the Egyptian Ophthalmological Society, 2023
Background To study the endothelial cell layer 3 months after Descemet membrane endothelial keratoplasty (DMEK) using specular microscopy to provide data about the endothelial cell density (ECD), endothelial cell loss (ECL) percentage, and changes in ...
Amira S.M Kamhawy, Osama A Salem, Yasser A El Zankalony, Ahmed A Ebeid   +3 more
doaj   +1 more source

Endothelial cell loss after photorefractive keratectomy for myopia [PDF]

Acta Ophthalmologica Scandinavica, 1998
To study the long-term effect of 193 nm excimer laser photorefractive keratectomy (PRK) on the human corneal endothelial cell density.One hundred and twenty-four eyes from 71 patients underwent photorefractive keratectomy for myopia or myopic-astigmatism.
Isager, P, Guo, S, Hjortdal, Jesper, Ehlers, N   +3 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Assessment of safety profile of phacoemulsification in hard cataract

Kerala Journal of Ophthalmology
Purpose: The aim of the study was to assess safety of phacoemulsification in hard cataract by evaluating the post-operative endothelial cell loss and visual acuity.
Soumya Patil, K H Srinivasa, Rakesha Anjenappa, Aswathi Menon   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source