Results 61 to 70 of about 1,177,249 (331)

Low expression of Notch1 may be associated with acute myocardial infarction

Frontiers in Cardiovascular Medicine
BackgroundThe transmembrane protein Notch1 is associated with cell growth, development, differentiation, proliferation, apoptosis, adhesion, and the epithelial mesenchymal transition.
Qing Zhang, Qing Zhang, Qing Zhang, Qing Zhang, Heyu Meng, Heyu Meng, Heyu Meng, Heyu Meng, Xue Wang, Xue Wang, Xue Wang, Xue Wang, Yanqiu Chen, Yanqiu Chen, Yanqiu Chen, Yanqiu Chen, Zhaohan Yan, Zhaohan Yan, Zhaohan Yan, Zhaohan Yan, Jianjun Ruan, Jianjun Ruan, Jianjun Ruan, Jianjun Ruan, Fanbo Meng, Fanbo Meng, Fanbo Meng, Fanbo Meng   +27 more
doaj   +1 more source

Wnt/beta-catenin signaling controls development of the blood–brain barrier [PDF]

, 2009
The blood–brain barrier (BBB) is confined to the endothelium of brain capillaries and is indispensable for fluid homeostasis and neuronal function. In this study, we show that endothelial Wnt/beta-catenin (beta-cat) signaling regulates induction and ...
Babbage, Jane, Bangsow, Thorsten, Corada, Monica, Czupalla, Cathrin Jacqueline, Dejana, Elisabetta, Felici, Angelina, Fruttiger, Marcus, Gerhardt, Holger, Liebner, Stefan, Melchner, Harald von (Prof. Dr.), Plate, Karl H., Reis, Marco, Taddei, Andrea, Taketo, Makoto Mark, Wolburg, Hartwig   +14 more
core  

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Magnetofection potentiates gene delivery to cultured endothelial cells [PDF]

, 2003
Modification of cellular functions by overexpression of genes is increasingly practised for research of signalling pathways, but restricted by limitations of low efficiency. We investigated whether the novel technique of magnetofection (MF) could enhance
Gloe, Torsten, Krötz, Florian, Plank, Christian, Pohl, Ulrich, Sohn, Hae-Young   +4 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Endothelial function assessment in atherosclerosis: Comparison of brachial artery flow‑mediated vasodilation and peripheral arterial tonometry [PDF]

, 2013
INTRODUCTION Endothelial dysfunction, characterized by the loss of nitric oxide bioavailability, is a key element in the pathogenesis of atherosclerosis and an important prognostic factor in cardiovascular diseases. Therefore, the development of reliable,
Czesnikiewicz-Guzik, Marta, Guzik, Tomasz J., Ignacak, Adam, Jasiewicz‑Honkisz, Barbara, Matusik, Paweł, Nowakowski, Daniel, Osmenda, Grzegorz, Wilk, Grzegorz   +7 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Changes in endothelial function during educational hospitalization and the contributor to improvement of endothelial function in type 2 diabetes mellitus

Scientific Reports, 2020
Only a few reports have examined vascular endothelial function before and after educational hospitalization and the factors that affect it in patients with type 2 diabetes mellitus (T2DM). The aim of this study was to assess vascular endothelial function
Yukiko Goshima, Yosuke Okada, Keiichi Torimoto, Yoshihisa Fujino, Yoshiya Tanaka   +4 more
doaj   +1 more source

Improving endothelial vasomotor function

BMJ, 2001
The vascular endothelium is a confluent, cellular monolayer that lines the entire vascular compartment at the interface between blood and the vessel wall. This “organ” possesses complex endocrine and paracrine functions and is intimately concerned in controlling vasomotor tone and preventing atherosclerosis and thrombosis.1 Indeed, endothelial ...
S N, Doshi, M J, Lewis, J, Goodfellow
openaire   +3 more sources

Isoflavones and endothelial function [PDF]

Nutrition Research Reviews, 2005
AbstractDietary isoflavones are thought to be cardioprotective due to their structural similarity to oestrogen. Oestrogen is believed to have beneficial effects on endothelial function and may be one of the mechanisms by which premenopausal women are protected against CVD.
Hall, W L, Rimbach, G, Williams, C M
openaire   +3 more sources