Results 81 to 90 of about 27,105 (199)

Commuting by bicycle (vs. by car) is associated with improved aerobic power, microvascular function and diminished CO2 output in the atmosphere

Experimental Physiology, EarlyView.
Abstract The study investigated whether bicycle compared with car commuting, over relatively small distances, has positive effects on physiological variables, cardiometabolic fitness and CO2 output in the atmosphere. Bike Commuters (11 M, 15 F; age [median value (interquartile range)] 51.5 (38.3–56.8) years; body mass index [BMI] 22.8 (21.0–24.1) kg m ...
Caterina Ursella, Giovanni Baldassarre, Lucrezia Zuccarelli, Federica Caponnetto, Francesco Curcio, Mattia D'Alleva, Maria De Martino, Elisabetta Fontanini, Andrea Palomba, Antonio Paolo Beltrami, Federico Formenti, Bruno Grassi   +11 more
wiley   +1 more source

Impaired nitric oxide‐dependent endothelial function in young male individuals with obesity before the onset of symptoms and complications

Experimental Physiology, EarlyView.
Abstract Endothelial dysfunction drives obesity‐related complications. Doppler ultrasound measurement of blood flow during 1‐min passive leg movements (PLM) is a valuable non‐invasive tool for assessing endothelial function and nitric oxide (NO)‐mediated vasodilation.
Lucrezia Zuccarelli, Giovanni Baldassarre, Adele Bondesan, Diana Caroli, Roberta De Micheli, Gabriella Tringali, Thomas Favaretto, Joanna Suraj‐Prazmowska, Anna Kurpinska, Joanna Majerczak, Stefan Chlopicki, Jerzy A. Zoladz, Alessandro Sartorio, Bruno Grassi   +13 more
wiley   +1 more source

Wall shear stress and arterial performance: two approaches based on engineering [PDF]

, 2009
This is the Abstract of the Article. Copyright @ 2009 Oxford University.This crucially important subject generates a very wide literature and the recent authoritative ‘in vivo’ review of Reneman et al [1] (& [2]), with Vennemann et al [3], are taken as ...
Atherton, MA, Collins, MW, Koenig, CS
core  

Three-dimensional low Reynolds number flows near biological filtering and protective layers

, 2017
Mesoscale filtering and protective layers are replete throughout the natural world. Within the body, arrays of extracellular proteins, microvilli, and cilia can act as both protective layers and mechanosensors.
Battista, Nicholas A., Hamlet, Christina, Miller, Laura A., Pasour, Virginia, Santhanakrishnan, Arvind, Strickland, W. Christopher   +5 more
core   +1 more source

Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms [PDF]

, 2016
Diabetes mellitus (DM) is the major cause of end-stage renal disease (ESRD) globally, and novel treatments are urgently needed. Current therapeutic approaches for diabetic nephropathy (DN) are focussing on blood pressure control with inhibitors of the ...
Coward, RJ, Gnudi, L, Long, DA
core   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Oligosaccharide model of the vascular endothelial glycocalyx in physiological flow [PDF]

, 2018
Experiments have consistently revealed the pivotal role of the endothelial glycocalyx layer in vasoregulation and the layer’s contribution to mechanotransduction pathways.
Pikoula, M, Tessier, MB, Ventikos, Y, Woods, RJ   +3 more
core   +1 more source

Neferine Protects Endothelial Glycocalyx via Mitochondrial ROS in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome

Frontiers in Physiology, 2018
Damage to the endothelial glycocalyx is a critical factor in increased pulmonary vascular permeability, which is the basic pathological feature of acute respiratory distress syndrome (ARDS).
Xiang-Yong Liu, Hai-Xiao Xu, Jian-Kui Li, Dong Zhang, Xiao-Hong Ma, Li-Na Huang, Jun-Hong Lü, Xiao-Zhi Wang   +7 more
doaj   +1 more source

Engineering Ultrasound Contrast Agents for Targeted Therapeutics: A Theranostic Approach to Drug Delivery, Gene Therapy, and Immunomodulation

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
Ultrasound contrast agents, including microbubbles and nanobubbles, transform imaging and targeted therapy through precise engineering of size, shell composition, and surface properties. This review explores how these innovations enable tissue‐specific delivery, enhance therapeutic efficacy, and extend applications from vascular imaging to tumor ...
Ashkan Seza, Kimia Mozahheb Yousefi, Sara Minaeian   +2 more
wiley   +1 more source

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian, Jun Ge, Ni Fan, Zheng Sun, Chengcheng Zhao, Yujiao Sun, Yingpeng Li, Yunfei Li, Hui Fu   +8 more
wiley   +1 more source