Results 101 to 110 of about 377,666 (204)

What do we know about nephrotoxicity of NSAIDs in horses?

Equine Veterinary Education, EarlyView.
C. Di Donato, G. van Galen
wiley   +1 more source

Curcumin in the Treatment of Various Diseases: Mechanism of Action, Bioavailability, Therapeutic Effects, and Current Clinical Trials

MedComm, Volume 7, Issue 11, November 2026.
Curcumin, a naturally occurring polyphenol, exhibits significant anti‐inflammatory and antioxidant capabilities. This review elucidates the specific molecular mechanisms by which curcumin exerts therapeutic effects on various diseases, including neurological disorders, cardiovascular diseases, cancers, inflammatory disorders, and autoimmune diseases ...
Lin Wang, Qifei Pan, Wenjuan Long, Xinyao Li, Jianqin Mao, Sitong Zhou, Zihui Wang, Xuelian Zou, Yuqing She, Mingqin Shi, Yang Zhou, Jiarong Du, Zhongyang Hu, Xiaoman Lv, Yishu Chen, Dongdong Qin   +15 more
wiley   +1 more source

A MUC13 Variant Enhances Intestinal Ferric Iron Absorption in Unexplained Hyperferritinemia

Liver International, Volume 46, Issue 11, November 2026.
ABSTRACT Background & Aims Hyperferritinemia frequently remains unexplained despite comprehensive evaluation. We conducted a sequencing‐based exome association study to identify genetic variants associated with plasma ferritin levels in patients with unexplained hyperferritinemia.
Jonas Callet, Yong H. Sheng, Yaowu He, Maël Silva Rodriguez, Céline Chéry, Ramia Safar, Françoise Barbé, Mouni Bensenane, Rosa‐Maria Guéant‐Rodriguez, Fares Namour, Guillaume Gauchotte, Janelle Louise Hancock, Hana Manceau, Thibaud Lefebvre, Dimitri Tchernitchko, Hervé Puy, Timothy H. Florin, Jakob Begun, John D. Hooper, Jean‐Pierre Bronowicki, Michael A. McGuckin, Jean‐Louis Guéant, Abderrahim Oussalah   +22 more
wiley   +1 more source

Cerebrovascular flow‐mediated dilation in humans: Methodological challenges, physiological interpretation and future integrations

Experimental Physiology, Volume 111, Issue 11, Page 5061-5073, 1 November 2026.
Abstract Arterial shear‐mediated vasodilation is a well‐established measure of endothelial function and serves as a critical biomarker for cardiovascular disease risk. Endothelial function can be measured using a variety of experimental methodologies; however, the most widely adopted technique is ultrasound‐based flow‐mediated dilation (FMD), in which ...
Yi Zhen Bao, Tabitha V. Craig, Jenna C. McCrone, Kurt J. Smith, Michael M. Tymko   +4 more
wiley   +1 more source

Endothelial Exostosin‐1 Is Needed for Glycocalyx Integrity and Inflammatory Resolution in Acute Lung Injury

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Endothelial Ext1 is essential for maintaining heparan sulfate–rich endothelial glycocalyx integrity. Loss of Ext1 reduces glycocalyx thickness, resulting in enhanced leukocyte adhesion, increased vascular permeability, and exaggerated inflammatory responses following lipopolysaccharide (LPS) challenge.
Yuki Kawasaki, Hiroyuki Tomita, Kodai Suzuki, Chihiro Takada, Hirotaka Asano, Soichiro Kano, Yugo Wakayama, Hirotsugu Fukuda, Toru Minamiyama, Genki Yoshimura, Ryo Kamidani, Yoshinori Kakino, Tomotaka Miura, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Akio Suzuki, Kazu Matsumoto, Nobuyuki Tetsuka, Shozo Yoshida, Yoichi Maekawa, Yu Yamaguchi, Hideshi Okada   +22 more
wiley   +1 more source

Endothelial glycocalyx conditions influence nanoparticle uptake for passive targeting

, 2016
Ming J Cheng,1 Rajiv Kumar,2 Srinivas Sridhar,1–3 Thomas J Webster,1,4 Eno E Ebong1 1Department of Chemical Engineering, 2Department of Physics, Northeastern University, 3Department of Radiation Oncology, Harvard Medical School, Boston, MA, USA ...
Sridhar S, Cheng MJ, Kumar R, Webster TJ, Ebong EE   +4 more
core  

Underappreciation of Endothelial Glycocalyx [PDF]

, 2018
Vascular endothelial glycocalyx is a fragile, gel-like substance found on the inside of the luminal wall of blood vessels. When damaged, either by hyperglycemia, hypoxia, hypervolemia, or inflammation, this fragile structure is degraded leaving the ...
Potts, Morgan
core  

Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-κB signaling in diabetic kidney disease

Cell Communication and Signaling
Background The incidence of diabetic kidney disease (DKD) continues to rapidly increase, with limited available treatment options. One of the hallmarks of DKD is persistent inflammation, but the underlying molecular mechanisms of early diabetic kidney ...
Siyuan Cui, Xin Chen, Jiayu Li, Wei Wang, Deqi Meng, Shenglong Zhu, Shiwei Shen   +6 more
doaj   +1 more source

Viscoelastic response of a model endothelial glycocalyx

Physical Biology, 2009
Many cells cover themselves with a multifunctional polymer coat, the pericellular matrix (PCM), to mediate mechanical interactions with the environment. A particular PCM, the endothelial glycocalyx (EG), is formed by vascular endothelial cells at their luminal side, forming a mechanical interface between the flowing blood and the endothelial cell layer.
Nijenhuis, Nadja, Mizuno, Daisuke, Spaan, Jos A. E., Schmidt, Christoph   +3 more
openaire   +4 more sources

Serial biomarkers of inflammation, endothelial activation and endothelial glycocalyx breakdown during hospital admission.

Serial biomarkers of inflammation, endothelial activation and endothelial glycocalyx breakdown during hospital admission.
Tran Thuy Vi (8703993), Martin J. Llewelyn (5029598), Louise Thwaites (5917460), Nguyen Thanh Ngoc (13671558), Huynh Thi Le Duyen (8703984), Luong Thi Hue Tai (13671561), Nguyen Van Hao (4437298), Nguyen Thanh Phong (7645706), Phan Vinh Tho (13671564), Angela McBride (8929265), Sophie Yacoub (622640), Lam Minh Yen (10224904), Phung Tran Huy Nhat (10224907), Nguyen Lam Vuong (5459501)   +13 more
core   +1 more source