Results 71 to 80 of about 377,666 (204)

Development of Versatile Nanoparticle System for Efficient Drug Delivery into Pulmonary Endothelium

Advanced Science, EarlyView.
Pediatric acute respiratory distress syndrome (PARDS) suppresses the FOXF1 transcription factor and disrupts lung development. This study shows that the FOXF1‐activating small‐molecule compound, TanFe[F], can be precisely delivered to lung endothelial cells using the innovative LEDD nanoparticle system.
Afzaal N. Mohammed, Zicheng Deng, Arnab Misra, Marcus Orzabal, Ananya Kondapally, Enhong Li, Jonathan Do, Ying‐Wei Lan, Fatemeh Kohram, Hunter Blackburn, Andreas Damianos, Tanya V. Kalin, Vladimir V. Kalinichenko   +12 more
wiley   +1 more source

High salt intake and HIV infection on endothelial glycocalyx shedding in salt-sensitive hypertension

Frontiers in Cell and Developmental Biology
The endothelial glycocalyx is closely associated with various physiological and pathophysiological events. Significant modification of the endothelial glycocalyx is an early process in the pathogenesis of cardiovascular disease. High dietary salt and HIV
Sepiso K. Masenga, Sepiso K. Masenga, Situmbeko Liweleya, Annet Kirabo, Annet Kirabo, Annet Kirabo, Annet Kirabo   +6 more
doaj   +1 more source

Mapping the Intellectual Structure of AI‐Driven ESG Cost Modeling: A Bibliometric Analysis of Trends, Themes, and Future Directions

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The bibliometric and qualitative analyses of 470 publications in the Web of Science Core Collection from 2004 through 2025 in this study associated the intellectual structure and thematic evolution of AI‐driven ESG cost modeling. The research commences using an integrated analytical framework consisting of three tools: (1) Bibliometrix (R) for
Nesreen Al‐Malkawi, Adriana Giret
wiley   +1 more source

Therapeutic Restoration of Endothelial Glycocalyx in Sepsis [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2017
Endothelial glycocalyx (EG) is disintegrated during sepsis. We have previously shown that this occurs very early in the course of sepsis and its prevention improves the survival of mice with sepsis. Here, we sought to investigate the possibility of pharmacologically accelerating the restoration of disintegrated EG in sepsis. We used a soilage injection
J W, Song, J A, Zullo, D, Liveris, M, Dragovich, X F, Zhang, M S, Goligorsky   +5 more
openaire   +3 more sources

Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score

ESC Heart Failure, Volume 12, Issue 2, Page 1427-1436, April 2025.
Abstract Background and objectives Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis.
Loïc Faucher, Kensuke Matsushita, Shinnosuke Kikuchi, Taraneh Tatarcheh, Benjamin Marchandot, Amandine Granier, Said Amissi, Antonin Trimaille, Laurence Jesel, Patrick Ohlmann, Kiyoshi Hibi, Valérie Schini‐Kerth, Olivier Morel   +12 more
wiley   +1 more source

Non‐Linear Threshold Effect of Dynamic Estimated Plasma Volume Status on Revealing In‐Hospital Mortality Risk in Sepsis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This retrospective cohort study evaluated the association between estimated plasma volume status (ePVS) and in‐hospital mortality in adult patients with sepsis from the MIMIC‐IV (v2.2) database. After excluding patients with early death, readmission, red blood cell transfusion, malignancy, or missing ePVS data, 17,403 patients meeting Sepsis‐3
Zhi‐An Si, Sheng‐Bing Xia, Yang Zou, Xiao‐Yan Wang   +3 more
wiley   +1 more source

The effect of perturbations of the glycocalyx on microvascular perfusion in the obese trauma population: an in vitro study

Trauma Surgery & Acute Care Open, 2021
Objectives Patients with morbid obesity have impaired responses to resuscitation following severe injury, which may contribute to adverse outcomes.
David Edelman, Lawrence N Diebel, Alexander Liviu Marinica, David Liberati   +3 more
doaj   +1 more source

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Responsive Materials, EarlyView.
This review presents the structure and transport routes of the blood‐brain barrier, summarizes the ischemic stroke pathophysiological cascade, and discusses the BBB‐crossing mechanisms and multitarget therapeutic effects of carbon dots, demonstrating their promising theranostic potential for ischemic stroke.
Yanhan Huang, Xuan Hou, Haiping Zhao, Qi Kong, Xiayan Wang, Xiaokun Geng, Zaicheng Sun   +6 more
wiley   +1 more source

John squire and endothelial glycocalyx structure: an unfinished story [PDF]

, 2023
John Squire did not only produce leading works in the muscle field, he also significantly contributed to the vascular permeability field by ultrastructural analysis of the endothelial glycocalyx. Presented here is a review of his involvement in the field
Wood, Elise A., Brown, Jennifer L. E., Michel, C. Charles, Small, Mathew O., Arkill, Kenton P., Kinnaird, Abigail L., Rider, Elizabeth V. M.   +6 more
core   +1 more source

No-Reflow Phenomenon and Endothelial Glycocalyx of Microcirculation [PDF]

Biochemistry Research International, 2012
The progress in reperfusion therapy dictated the necessity for developing new tools and procedures for adjacent/additional therapy of acute cardiovascular disorders. The adjacent therapy is targeted on the damage of the microcirculation, leading to the unfavorable prognosis for the patients.
Alexander V. Maksimenko, Askar D. Turashev   +1 more
openaire   +3 more sources