Results 51 to 60 of about 124,593 (307)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Nestin Protein Is Phosphorylated in Adult Neural Stem/Progenitor Cells and Not Endothelial Progenitor Cells

Stem Cells International, 2012
An intermediate filament protein, Nestin, is known as a neural stem/progenitor cell marker. It was shown to be required for the survival and self-renewal of neural stem cells according to the phenotypes of Nestin knockout mice. Nestin expression has also
Jun Namiki, Sayuri Suzuki, Takeshi Masuda, Yasushi Ishihama, Hideyuki Okano   +4 more
doaj   +1 more source

Fractalkine expression induces endothelial progenitor cell lysis by natural killer cells. [PDF]

PLoS ONE, 2011
BACKGROUND: Circulating CD34(+) cells, a population that includes endothelial progenitors, participate in the maintenance of endothelial integrity.
Dilyana Todorova, Florence Sabatier, Evelyne Doria, Luc Lyonnet, Henri Vacher Coponat, Stéphane Robert, Nicolas Despoix, Tristan Legris, Valérie Moal, Anderson Loundou, Sophie Morange, Yvon Berland, Francoise Dignat George, Stéphane Burtey, Pascale Paul   +14 more
doaj   +1 more source

Molecular mechanisms and modulation of Endothelial Progenitor Cell function in South Asian men [PDF]

, 2012
South Asian ethnicity has long been considered a contributory factor in the development of atherosclerosis and cardiovascular disease. Endothelial dysfunction is considered to be the precursor of atherosclerosis, and South Asian ethnicity has been linked
Baliga, Vivek
core  

Circulating humoral factors and endothelial progenitor cells in patients with differing coronary collateral support

, 2004
Background - The mechanisms underlying the variation in collateral formation between patients, even with similar patterns of coronary artery disease, remain unclear.
Bucknall, CA, Meng, Y G, Redwood, SR, Pearson, JD, Redwood, S R, Edwards, R J, Lambiase, PD, Marber, MS, Edwards, RJ, Anthopoulos, P, Rahman, S, Lambiase, P D, Meng, YG, Pearson, J D, Marber, M S; id_orcid, Bucknall, C A   +15 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

High calcium bioglass enhances differentiation and survival of endothelial progenitor cells, inducing early vascularization in critical size bone defects

, 2013
Early vascularization is a prerequisite for successful bone healing and endothelial progenitor cells (EPC), seeded on appropriate biomaterials, can improve vascularization.
Marzi, Ingo, Eldesoqi, Karam, Christoph Nau, Schaible, Alexander, Dirk Henrich, Karam Eldesoqi, Alexander Schaible, Ngoc, Christina Nguyen, Christina Nguyen Ngoc, Henrich, Dirk, Ingo Marzi, Seebach, Caroline, Nau, Christoph, Caroline Seebach, Simon Meier, Meier, Simon   +15 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source