Results 151 to 160 of about 268,157 (315)

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source

Serum-free Quality and Quantity Control Culture Improves the Angiogenic Potential of Peripheral Blood Mononuclear Cells Harvested from Patients with Connective Tissue Diseases

Journal of Plastic and Reconstructive Surgery
Objectives: The number and quality of endothelial progenitor cells decrease in patients with connective tissue diseases. This limits the efficacy of mononuclear cell therapy for ischemic ulcers associated with connective tissue diseases.
Satomi Furukawa, Rie Hirano, Ai Sugawara, Satoshi Fujimura, Rica Tanaka   +4 more
doaj  

Human Vasculogenesis Ex Vivo: Embryonal Aorta as a Tool for Isolation of Endothelial Cell Progenitors [PDF]

, 2001
Giulio Alessandri, Marina Girelli, Gianluca Taccagni, Augusto Colombo, Roberto F. Nicosia, Arnaldo Caruso, Manuela Baronio, Stefano Pagano, Lidia Cova, Eugenio Parati   +9 more
openalex   +1 more source

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Advanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, Li Yang   +5 more
wiley   +1 more source

Therapeutic Potential of Ex Vivo Expanded Endothelial Progenitor Cells for Myocardial Ischemia [PDF]

, 2001
Atsuhiko Kawamoto, Heon-Cheol Gwon, Hideki Iwaguro, Jun‐ichi Yamaguchi, Shigeki Uchida, Haruchika Masuda, Marcy Silver, Hong Ma, Marianne Kearney, Jeffrey M. Isner, Takayuki Asahara   +10 more
openalex   +1 more source

Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

Advanced Science, EarlyView.
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song, Zhichao Tong, Guixiang Xie, Yaowei Li, Yubo Zhao, Fengpu Fan, Zongzheng Yang, Qing Shi, Qian Zhang, Feng Wen, Hongxue Meng, Haonan Li, Pengyu Guo, Dayong Hou, Zhenwei Zhang, Zhihao Yin, Ziyi Liu, Jianwei Wang, Peng Zhang, Peng Dai, Changfu Li, Lichen Teng, Yangyang Xu, Dexin Ding, Tao Xu, Jianzhang Li, Yongsheng Chen, Yu Qiu, XiaoWei Hu, Wentao Liu, Liang Wu, Roman Nawroth, Guibo Li, Hang Su, Ziqing Deng, Ziqi Wang, Di Wang, Wanhai Xu   +37 more
wiley   +1 more source

High-intensity intermittent exercise regulates oxidative stress and improves endothelial progenitor cell function in patients with essential hypertension

环境与职业医学
BackgroundVascular endothelial damage associated with endothelial progenitor cell dysfunction is considered as an initiating step of hypertension and target organ damage, in which oxidative stress plays a key role. High-intensity intermittent exercise is
Jixin ZHI, Tiantian WANG, Shuang REN, Chenyu WANG   +3 more
doaj   +1 more source

Mobilization of Endothelial Progenitor Cells in Patients With Acute Myocardial Infarction [PDF]

, 2001
Satoshi Shintani, Toyoaki Murohara, Hisao Ikeda, Takafumi Ueno, Tomoki Honma, Atsushi Katoh, Ken-ichiro Sasaki, Toshifumi Shimada, Yuichi Oike, Tsutomu Imaizumi   +9 more
openalex   +1 more source

3D‐Printed Titanium Trabecular Scaffolds with Sustained Release of Hypoxia‐Induced Exosomes for Dual‐Mimetic Bone Regeneration

Advanced Science, EarlyView.
This study presents 3D‐printed Ti‐6Al‐4V trabecular scaffolds combined with hypoxia‐induced exosomes encapsulated in PEGDA/GelMA microspheres for sustained release. The scaffolds mimic the structure of natural bone, while the exosome delivery system enhances osteogenesis and angiogenesis, significantly promoting bone regeneration and offering a ...
Lincong Luo, Weihan Zheng, Jiaying Li, Tingting Chen, Wanting Xue, Tao Lin, Mingrui Liu, Zi Yan, Jiaxin Yang, Jiamin Li, Jiahao Pu, Yaobin Wu, Konghe Hu, Shiyu Li, Wenhua Huang   +14 more
wiley   +1 more source

Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease [PDF]

, 2001
M Vasa, S Fichtlscherer
openalex   +1 more source