Results 21 to 30 of about 1,271,424 (340)

An updated view on the differentiation of stem cells into endothelial cells [PDF]

Science China Life Sciences, 2014
Endothelial cells form the internal barrier between circulating blood and the vessel wall. They regulate arterial activity and mediate pathological reactions to vascular injuries such as atherosclerosis and balloon angioplasty. The development and differentiation of endothelial cells is a complex and coordinated process involving multiple levels of ...
Feng Yang, Yutao Wu, Jianhua Zhu, Ting Chen, Yijiang Zhou, Li Zhang, Mei Yang   +6 more
openaire   +3 more sources

Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Human PSC-derived iBMECs have been generated to study disease mechanisms and drug development for neurological disorders. However, their full transcriptomic characterization is unclear, which could result in inaccurate physiological studies ...
T. Lu, S. Houghton, T. Magdeldin, J. G. B. Durán, Andrew P. Minotti, A. Snead, A. Sproul, Duc-Huy T. Nguyen, J. Xiang, H. Fine, Z. Rosenwaks, L. Studer, S. Rafii, D. Agalliu, D. Redmond, R. Lis   +15 more
semanticscholar   +1 more source

Endothelial and perivascular cells maintain haematopoietic stem cells [PDF]

Nature, 2012
Several cell types have been proposed to create niches for haematopoietic stem cells (HSCs). However, the expression patterns of HSC maintenance factors have not been systematically studied and no such factor has been conditionally deleted from any candidate niche cell. Thus, the cellular sources of these factors are undetermined. Stem cell factor (SCF;
Sean J. Morrison, Grigori Enikolopov, Thomas L. Saunders, Lei Ding   +3 more
openaire   +3 more sources

Application of vascular endothelial cells in stem cell medicine

World Journal of Clinical Cases, 2021
Stem cell medicine is gaining momentum in the development of therapy for various end-stage diseases. The search for new seed cells and exploration of their application prospects are topics of interest in stem cell medicine. In recent years, vascular endothelial cells (VECs) have attracted wide attention from scholars.
Liang, Qing-Qing, Liu, Lei
openaire   +2 more sources

PDGFD switches on stem cell endothelial commitment

Angiogenesis, 2022
AbstractThe critical factors regulating stem cell endothelial commitment and renewal remain not well understood. Here, using loss- and gain-of-function assays together with bioinformatic analysis and multiple model systems, we show that PDGFD is an essential factor that switches on endothelial commitment of embryonic stem cells (ESCs).
Weisi Lu, Peipei Xu, Boxiong Deng, Jianing Zhang, Ying Zhan, Xianchai Lin, Xiangzhong Xu, Zhaoxia Xia, Xiaoxi Yang, Xiaoling Zeng, Lijuan Huang, Bingbing Xie, Chenghu Wang, Shasha Wang, Haiqing Kuang, Xianjing Han, Antonio Mora, Yihai Cao, Qin Jiang, Xuri Li   +19 more
openaire   +2 more sources

Persistence of recipient-type endothelium after allogeneic hematopoietic stem cell transplantation

Haematologica, 2011
Background The possibility that allogeneic hematopoietic stem cell transplantation performed across the ABO blood group-barrier is associated with an increase of graft-versus-host disease, in particular endothelial damage, has not been elucidated so far.
Regula J. Mueller, Georg Stussi, Gisella Puga Yung, Milica Nikolic, Davide Soldini, Jörg Halter, Sandrine Meyer-Monard, Alois Gratwohl, Jakob R. Passweg, Bernhard Odermatt, Urs Schanz, Barbara C. Biedermann, Jörg D. Seebach   +12 more
doaj   +1 more source

Endothelial induced EMT in breast epithelial cells with stem cell properties. [PDF]

PLoS ONE, 2011
Epithelial to mesenchymal transition (EMT) is a critical event in cancer progression and is closely linked to the breast epithelial cancer stem cell phenotype.
Valgardur Sigurdsson, Bylgja Hilmarsdottir, Hekla Sigmundsdottir, Agla J R Fridriksdottir, Markus Ringnér, Rene Villadsen, Ake Borg, Bjarni A Agnarsson, Ole William Petersen, Magnus K Magnusson, Thorarinn Gudjonsson   +10 more
doaj   +1 more source

Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow

Nature Communications, 2018
Endothelial cells (ECs) contribute to haematopoietic stem cell (HSC) maintenance in bone marrow, but the differential contributions of EC subtypes remain unknown, owing to the lack of methods to separate with high purity arterial endothelial cells (AECs)
Chunliang Xu, Xin Gao, Qiaozhi Wei, F. Nakahara, Samuel E. Zimmerman, J. Mar, P. Frenette   +6 more
semanticscholar   +1 more source

Human intracardiac SSEA4+CD34 cells show features of cycling, immature cardiomyocytes and are distinct from Side Population and C-kit+CD45- cells

PLoS ONE, 2022
Cardiomyocyte proliferation has emerged as the main source of new cardiomyocytes in the adult. Progenitor cell populations may on the other hand contribute to the renewal of other cell types, including endothelial and smooth muscle cells.
Mikael Sandstedt, Kristina Vukusic, Benjamin Ulfenborg, Marianne Jonsson, Lillemor Mattsson Hultén, Göran Dellgren, Anders Jeppsson, Jane Synnergren, Joakim Sandstedt   +8 more
doaj   +3 more sources

Generation of Functional Blood Vessels from a Single c-kit+ Adult Vascular Endothelial Stem Cell

PLoS Biology, 2012
Adult vascular endothelial stem cells are shown to reside in the blood vessel wall endothelium. When isolated, these cells are capable of clonal expansion and generate functional blood vessels in vivo.
Shentong Fang, Jing Wei, Nalle Pentinmikko, H. Leinonen, P. Salvén   +4 more
semanticscholar   +1 more source