IFNα-mediated remodeling of endothelial cells in the bone marrow niche
Haematologica, 2017 In the bone marrow, endothelial cells are a major component of the hematopoietic stem cell vascular niche and are a first line of defense against inflammatory stress and infection.
Áine M. Prendergast +5 more
doaj +1 more source
Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice
Angiogenesis, 2023 AbstractTissue-resident vascular endothelial stem cells (VESCs), marked by expression of CD157, possess long-term repopulating potential and contribute to vascular regeneration and homeostasis in mice. Stem cell exhaustion is regarded as one of the hallmarks of aging and is being extensively studied in several types of tissue-resident stem cells ...
Shimizu, Shota +7 more
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The light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine [PDF]
, 2017 Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised ...
Cavarretta, Elena +9 more
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Transition of mesenchymal stem/stromal cells to endothelial cells [PDF]
Stem Cell Research & Therapy, 2013 Mesenchymal stem/stromal cells (MSCs) are heterogeneous. A fraction of these cells constitute multipotent cells that can self-renew and mainly give rise to mesodermal lineage cells such as adipocytes, osteocytes and chondrocytes. The ability of MSCs to differentiate into endothelial cells remains controversial.
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Angiogenic and Immunomodulatory Properties of Endothelial and Mesenchymal Stem Cells [PDF]
Tissue Engineering Part A, 2016 It has been suggested that the effect of implanted cells on the local environment is important when selecting the appropriate cell type for tissue regeneration. Our aim was to compare the local tissue response to implanted human mesenchymal stem cells (MSC) and human umbilical vein endothelial cells (EC). MSC and EC were cultured in poly(L-lactide-co-1,
Bartaula-Brevik, Sushma +4 more
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Hypoxic pre-conditioning increases the infiltration of endothelial cells into scaffolds for dermal regeneration pre-seeded with mesenchymal stem cells. [PDF]
, 2015 Many therapies using mesenchymal stem cells (MSC) rely on their ability to produce and release paracrine signals with chemotactic and pro-angiogenic activity.
Beegle, Julie R +6 more
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A Mesoderm-Derived Precursor for Mesenchymal Stem and Endothelial Cells [PDF]
Cell Stem Cell, 2010 Among the three embryonic germ layers, the mesoderm is a major source of the mesenchymal precursors giving rise to skeletal and connective tissues, but these precursors have not previously been identified and characterized. Using human embryonic stem cells directed toward mesendodermal differentiation, we show that mesenchymal stem/stromal cells (MSCs)
Junying Yu +7 more
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Frontiers in Cardiovascular Medicine, 2023 The generation of endothelial cells (ECs) from human pluripotent stem cells (PSCs) has been a promising approach for treating cardiovascular diseases for several years.
Kyung Mu Noh +3 more
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Zebrafish Caudal Haematopoietic Embryonic Stromal Tissue (CHEST) Cells Support Haematopoiesis. [PDF]
, 2017 Haematopoiesis is an essential process in early vertebrate development that occurs in different distinct spatial locations in the embryo that shift over time.
Aggio, Julian +6 more
core +1 more source
The effect of bisphosphonates on the endothelial differentiation of mesenchymal stem cells [PDF]
Scientific Reports, 2016 AbstractThe contribution of the local stem cell niche to providing an adequate vascular framework during healing cannot be overemphasized. Bisphosphonates (BPs) are known to have a direct effect on the local vasculature, but their effect on progenitor cell differentiation is unknown.
Sharma, Dileep +3 more
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