Results 41 to 50 of about 1,271,424 (340)
Stem and endothelial progenitor cells in erection biology [PDF]
International Journal of Impotence Research, 2008 Erectile dysfunction (ED) is defined as the consistent inability to obtain or maintain an erection for satisfactory sexual relations. The past 20 years of basic science research on erection physiology has been devoted to investigating the pathogenesis of ED and has led to the conclusion that ED is predominately a disease of vascular origin with ...
Trinity J. Bivalacqua +4 more
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Measurement of Mesenchymal Stem Cells Attachment to Endothelial Cells
BIO-PROTOCOL, 2018 Mesenchymal stem cells (MSCs) have shown profound therapeutic potential in tissue repair and regeneration. However, recent studies indicate that MSCs are largely entrapped in lungs after intravenous delivery and die shortly. The underlying mechanisms have been poorly understood. We have provided evidence to show that excess expression and activation of
Chris D. Madsen, Shan Wang, Yaojiong Wu
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Angiogenic potential of endothelial progenitor cells and embryonic stem cells [PDF]
Vascular Cell, 2011 Endothelial progenitor cells (EPCs) are implicated in a range of pathological conditions, suggesting a natural therapeutic role for EPCs in angiogenesis. However, current angiogenic therapies involving EPC transplantation are inefficient due to rejection of donor EPCs.
Peter C Rae +6 more
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Effects of shear stress on differentiation of stem cells into endothelial cells
World Journal of Stem Cells, 2021 Stem cell transplantation is an appealing potential therapy for vascular diseases and an indispensable key step in vascular tissue engineering. Substantial effort has been made to differentiate stem cells toward vascular cell phenotypes, including endothelial cells (ECs) and smooth muscle cells.
Jia-Yi Qian +3 more
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Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice
Angiogenesis, 2023 AbstractTissue-resident vascular endothelial stem cells (VESCs), marked by expression of CD157, possess long-term repopulating potential and contribute to vascular regeneration and homeostasis in mice. Stem cell exhaustion is regarded as one of the hallmarks of aging and is being extensively studied in several types of tissue-resident stem cells ...
Shimizu, Shota +7 more
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IFNα-mediated remodeling of endothelial cells in the bone marrow niche
Haematologica, 2017 In the bone marrow, endothelial cells are a major component of the hematopoietic stem cell vascular niche and are a first line of defense against inflammatory stress and infection.
Áine M. Prendergast +5 more
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Transition of mesenchymal stem/stromal cells to endothelial cells [PDF]
Stem Cell Research & Therapy, 2013 Mesenchymal stem/stromal cells (MSCs) are heterogeneous. A fraction of these cells constitute multipotent cells that can self-renew and mainly give rise to mesodermal lineage cells such as adipocytes, osteocytes and chondrocytes. The ability of MSCs to differentiate into endothelial cells remains controversial.
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A Mesoderm-Derived Precursor for Mesenchymal Stem and Endothelial Cells [PDF]
Cell Stem Cell, 2010 Among the three embryonic germ layers, the mesoderm is a major source of the mesenchymal precursors giving rise to skeletal and connective tissues, but these precursors have not previously been identified and characterized. Using human embryonic stem cells directed toward mesendodermal differentiation, we show that mesenchymal stem/stromal cells (MSCs)
Junying Yu +7 more
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Frontiers in Cardiovascular Medicine, 2023 The generation of endothelial cells (ECs) from human pluripotent stem cells (PSCs) has been a promising approach for treating cardiovascular diseases for several years.
Kyung Mu Noh +3 more
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PLoS ONE, 2015 Aim To generate human embryonic stem cell derived corneal endothelial cells (hESC-CECs) for transplantation in patients with corneal endothelial dystrophies.
K. McCabe +5 more
semanticscholar +1 more source