Results 21 to 30 of about 5,863,268 (295)

Placental growth factor expression is required for bone marrow endothelial cell support of primitive murine hematopoietic cells. [PDF]

PLoS ONE, 2013
Two distinct microenvironmental niches that regulate hematopoietic stem/progenitor cell physiology in the adult bone marrow have been proposed; the endosteal and the vascular niche.
Xiaoying Zhou, Lora W Barsky, Gregor B Adams   +2 more
doaj   +1 more source

Endothelial and perivascular cells maintain haematopoietic stem cells [PDF]

Nature, 2012
Several cell types have been proposed to create niches for haematopoietic stem cells (HSCs). However, the expression patterns of HSC maintenance factors have not been systematically studied and no such factor has been conditionally deleted from any candidate niche cell. Thus, the cellular sources of these factors are undetermined. Stem cell factor (SCF;
Ding, Lei, Saunders, Thomas L., Enikolopov, Grigori, Morrison, Sean J.   +3 more
openaire   +2 more sources

Gap Junction–Mediated Transport of Metabolites Between Stem Cells and Vascular Endothelial Cells

Cell Transplantation, 2022
We have previously demonstrated that small molecular transfer, such as glucose, between hematopoietic stem cells (HSCs) or mesenchymal stem cells (MSCs) and vascular endothelial cells via gap junctions constitutes an important mechanism of stem cell ...
Yuko Ogawa, Rie Akamatsu, Akihiro Fuchizaki, Kazuta Yasui, Orie Saino, Mitsunobu Tanaka, Akie Kikuchi-Taura, Takafumi Kimura, Akihiko Taguchi   +8 more
doaj   +1 more source

PDGFD switches on stem cell endothelial commitment

Angiogenesis, 2022
AbstractThe critical factors regulating stem cell endothelial commitment and renewal remain not well understood. Here, using loss- and gain-of-function assays together with bioinformatic analysis and multiple model systems, we show that PDGFD is an essential factor that switches on endothelial commitment of embryonic stem cells (ESCs).
Weisi Lu, Peipei Xu, Boxiong Deng, Jianing Zhang, Ying Zhan, Xianchai Lin, Xiangzhong Xu, Zhaoxia Xia, Xiaoxi Yang, Xiaoling Zeng, Lijuan Huang, Bingbing Xie, Chenghu Wang, Shasha Wang, Haiqing Kuang, Xianjing Han, Antonio Mora, Yihai Cao, Qin Jiang, Xuri Li   +19 more
openaire   +2 more sources

Differentiation of pluripotent stem cells into endothelial cells [PDF]

Current Opinion in Hematology, 2015
Methods to isolate endothelial cells from murine and human pluripotent stem cells continue to evolve and increasingly diverse endothelial cell populations have been generated. This review provides an update of key articles published within the past year that report on some of those advances.Cooperative interactions among microRNA (miRNA), transcription
openaire   +3 more sources

Protein changes associated with embryonic stem cell differentiation to vascular smooth muscle cells [PDF]

, 2006
PhDEmbryonic stem (ES) cells can differentiate into many different cell lines, including vascular smooth muscle cells (SMCs). The aim of this project is to characterize protein changes during this differentiation process.
Yin, Xiaoke
core   +4 more sources

Stem and endothelial progenitor cells in erection biology [PDF]

International Journal of Impotence Research, 2008
Erectile dysfunction (ED) is defined as the consistent inability to obtain or maintain an erection for satisfactory sexual relations. The past 20 years of basic science research on erection physiology has been devoted to investigating the pathogenesis of ED and has led to the conclusion that ED is predominately a disease of vascular origin with ...
T D, Strong, M A, Gebska, H C, Champion, A L, Burnett, T J, Bivalacqua   +4 more
openaire   +2 more sources

Persistence of recipient-type endothelium after allogeneic hematopoietic stem cell transplantation

Haematologica, 2011
Background The possibility that allogeneic hematopoietic stem cell transplantation performed across the ABO blood group-barrier is associated with an increase of graft-versus-host disease, in particular endothelial damage, has not been elucidated so far.
Regula J. Mueller, Georg Stussi, Gisella Puga Yung, Milica Nikolic, Davide Soldini, Jörg Halter, Sandrine Meyer-Monard, Alois Gratwohl, Jakob R. Passweg, Bernhard Odermatt, Urs Schanz, Barbara C. Biedermann, Jörg D. Seebach   +12 more
doaj   +1 more source

Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice

Angiogenesis, 2023
AbstractTissue-resident vascular endothelial stem cells (VESCs), marked by expression of CD157, possess long-term repopulating potential and contribute to vascular regeneration and homeostasis in mice. Stem cell exhaustion is regarded as one of the hallmarks of aging and is being extensively studied in several types of tissue-resident stem cells ...
Shimizu, Shota, Iba, Tomohiro, Naito, Hisamichi, Rahmawati, Fitriana Nur, Konishi, Hirotaka, Jia, Weizhen, Muramatsu, Fumitaka, Takakura, Nobuyuki   +7 more
openaire   +2 more sources

Insulin-like growth factors promote vasculogenesis in embryonic stem cells. [PDF]

PLoS ONE, 2012
The ability of embryonic stem cells to differentiate into endothelium and form functional blood vessels has been well established and can potentially be harnessed for therapeutic angiogenesis.
Stephanie M Piecewicz, Ambarish Pandey, Bhaskar Roy, Soh Hua Xiang, Bruce R Zetter, Shiladitya Sengupta   +5 more
doaj   +1 more source