Results 31 to 40 of about 208,585 (381)
Endothelin signalling mediates experience-dependent myelination in the CNS
eLife, 2019 Experience and changes in neuronal activity can alter CNS myelination, but the signalling pathways responsible remain poorly understood. Here we define a pathway in which endothelin, signalling through the G protein-coupled receptor endothelin receptor B
Matthew Swire +4 more
semanticscholar +1 more source
Computational and Structural Biotechnology Journal, 2013 Introduction: The flux of uremic toxin middle molecules through currently used hemodialysis membranes is suboptimal, mainly because of the membranes' pore architecture.
Assem Hedayat +3 more
doaj +1 more source
ET-1 as a Sex-Specific Mechanism Impacting Age-Related Changes in Vascular Function
Frontiers in Aging, 2021 Aging is a primary risk factor for cardiovascular disease (CVD), which is the leading cause of death in developed countries. Globally, the population of adults over the age of 60 is expected to double by the year 2050.
Andrew V. Kuczmarski +4 more
doaj +1 more source
Diabetic retinopathy and endothelin system: microangiopathy versus endothelial dysfunction
Eye, 2018 In the face of the global epidemic of diabetes, it is critical that we update our knowledge about the pathogenesis of diabetes and the related micro alterations on the vascular network in the body.
F. Sorrentino +4 more
semanticscholar +1 more source
Endothelin and menstruation [PDF]
Human Reproduction, 1996 Endothelin (ET) and its mRNA are present in human endometrium. Its expression varies across the menstrual cycle, reaching maximal levels in the pre-menstrual phase. Human endometrial epithelial cells are the major in-vitro source of ET, and its release is affected by the stage of the menstrual cycle from which the endometrium is taken and by the ...
Marion M Marsh +2 more
openaire +2 more sources
Truncated human endothelin receptor A produced by alternative splicing and its expression in melanoma [PDF]
, 1998 In this study, reverse transcriptase polymerase chain reaction was used to amplify human endothelin receptor A (ETA) and ETB receptor mRNA. A truncated ETA receptor transcript with exons 3 and 4 skipped was found.
Berry, PA +5 more
core +1 more source
Attenuation of ischemic liver injury by monoclonal anti-endothelin antibody, awETN40 [PDF]
, 1997 Background: Enhanced production of endothelin-1 (ET1), vasoconstrictive 21 amino acids produced by endothelial cells during ischemia and after reperfusion of the liver, is known to cause sinusoidal constriction and microcirculatory disturbances, which ...
Ishizaki, N +10 more
core +1 more source
Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx.
Journal of the American Society of Nephrology, 2016 Diabetic nephropathy (DN) is the leading cause of CKD in the Western world. Endothelin receptor antagonists have emerged as a novel treatment for DN, but the mechanisms underlying the protective effect remain unknown.
M. Garsen +9 more
semanticscholar +1 more source
Life Sciences, 2012 Following the initial description of endothelium-dependent vasoconstriction in the early 1980s, it has been exactly 25 years since efforts to identify the sequence of the endothelin gene and peptide began in May 1987, work which resulted in a landmark paper submitted to Nature in December 1987 and published on March 31, 1988.
Yanagisawa, M +3 more
openaire +4 more sources
Journal of Ophthalmology, 2016 Purpose. The aim of this meta-analysis was to clarify the association between the plasma endothelin-1 level and the risks of normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG). Methods.
S. Li +3 more
semanticscholar +1 more source