Results 121 to 130 of about 37,353 (347)

Paradoxical sleep deprivation increases plasma endothelin levels

Brazilian Journal of Medical and Biological Research, 2002
The endothelins (ET-1, 2 and 3) constitute a family of 21 amino acid peptides with potent biological activities. ET-1 is one of the most potent endogenous vasoconstrictors so far identified and its increased concentration in plasma appears to be closely ...
B.D. Palma, A. Gabriel Jr., M. Bignotto, S. Tufik   +3 more
doaj   +1 more source

Endothelin‐1 induces expression of fetal genes through the interleukin‐6 family of cytokines in cardiac myocytes [PDF]

, 1999
Shuichi Saito, Ryuichi Aikawa, Ichiro Shiojima, Ryozo Nagai, Yoshio Yazaki, Issei Komuro   +5 more
openalex   +1 more source

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

Brain Pathology, EarlyView.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong, Weixing Yan, Qiqi Meng, Xueli Song, Bing Cheng, Yaping Liu, Yanan Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension

British Journal of Pharmacology, EarlyView.
Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z. M. Homer, Sébastien Bonnet, Sandra Breuils‐Bonnet, Martin Wabitsch, Margaret R. MacLean   +12 more
wiley   +1 more source

The Discovery of Nonpeptide Endothelin Receptor Antagonists. Progression towards Bosentan

CHIMIA, 1996
Since its discovery, endothelin-1 has attracted considerable scientific interest for its extremely potent and long-lasting vasoconstrictor effect and its binding to G-protein-coupled receptors.
Werner Neidhart, Volker Breu, Daniel Bur, Kaspar Burri, Martine Clozel, Georges Hirth, Marcel Müller, Hans P. Wessel, Henri Ramuz   +8 more
doaj   +2 more sources

Inverse correlation between endothelin-1-induced peripheral microvascular vasoconstriction and blood pressure in glaucoma patients [PDF]

, 2018
• Background: The potent vasoconstrictor peptide endothelin-I has been shown to participate in the control of peripheral vascular tone and in the regulation of ocular perfusion.
Flammer, Josef, Gass, Andreas, Gasser, Paul, Haefeli, Walter, Linder, Lilly, Romerio, Silvana   +5 more
core  

TNF‐α partially modulates the endothelial dysfunction during the acute phase of Trypanosoma cruzi infection

British Journal of Pharmacology, EarlyView.
Background and Purpose Whereas the effects of Trypanosoma cruzi (T. cruzi) infection are well‐characterised in the heart, its impact on the vasculature has received little attention. In this study, we investigated the effects of acute and chronic T. cruzi infection on vascular responsiveness and the underlying mechanisms.
Thales M. H. Dourado, Wanessa M. C. Awata, Gustavo F. Pimenta, Barbara M. Marchetti, Maiara V. Providello, Sérgio De Albuquerque, Carlos R. Tirapelli   +6 more
wiley   +1 more source

Cardiovascular, catecholamine, and endothelin-1 responses to stress in young adults [PDF]

, 2001
Bruce S. Alpert
openalex   +1 more source

Endothelin Receptor-A Inhibition Decreases Ductular Reaction, Liver Fibrosis, and Angiogenesis in a Model of Cholangitis

, 2023
Travis Owen, Guido Carpino, Lixian Chen, Debjyoti Kundu, Payton G. Wills, Burcin Ekser, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Heather Francis, Lindsey Kennedy   +10 more
openalex   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source