Results 121 to 130 of about 36,666 (331)
Oligodendrogenesis in Evolution, Development and Adulthood
Glia, EarlyView.Oligodendrocytes and myelin took shape in jawed vertebrates. During development, OPCs are originated from NSCs and then undergo differentiation into mature oligodendrocytes that supply myelin. OPCs persist in the adult CNS and continue to produce oligodendrocytes and myelin. Adaptive myelination, which fine‐tunes neural circuits in response to neuronal
Hao Hu +3 more
wiley +1 more source
Endothelin-3 is epigenetically silenced in endometrioid endometrial cancer. [PDF]
J Cancer Res Clin Oncol, 2023 Zmarzły N +7 more
europepmc +1 more source
Endothelin Receptors and Their Antagonists
Seminars in Nephrology, 2015 All three members of the endothelin (ET) family of peptides, ET-1, ET-2, and ET-3, are expressed in the human kidney, with ET-1 being the predominant isoform. ET-1 and ET-2 bind to two G-protein-coupled receptors, ETA and ETB, whereas at physiological concentrations ET-3 has little affinity for the ET(A) receptor.
Maguire, Janet J, Davenport, Anthony P
openaire +4 more sources
Research progress of neurovascular units involved in ischemic stroke
Ibrain, EarlyView.The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang +4 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang +4 more
wiley +1 more source
Three apparent receptor subtypes for the endothelin/sarafotoxin family [PDF]
, 1989 Yoel Kloog +3 more
openalex +1 more source
Diffuse Melanosis Cutis Under Immuno‐ and Targeted Therapy
JEADV Clinical Practice, EarlyView.ABSTRACT In patients with highly advanced melanoma, rarely a diffuse melanosis cutis (DMC) can be noticed. Even though the condition is generally harmless itself, it can have a significant impact on the patient's well‐being as an obvious mark of the disease. DMC causes a grey or brown discoloration of the skin and mucous membranes. We report on a young
Christiane Cussigh +3 more
wiley +1 more source
The Discovery of Nonpeptide Endothelin Receptor Antagonists. Progression towards Bosentan
CHIMIA, 1996 Since its discovery, endothelin-1 has attracted considerable scientific interest for its extremely potent and long-lasting vasoconstrictor effect and its binding to G-protein-coupled receptors.
Werner Neidhart +8 more
doaj +2 more sources
Biomolecular Concepts, 2013 In addition to their potent vasoconstriction effects, endothelins (ETs) show multiple actions in various tissues including the brain. The brain contains high levels of ETs, and their production is stimulated in many brain disorders. Accumulating evidence
Koyama Yutaka
doaj +1 more source
Medicine Bulletin, EarlyView.ABSTRACT Background Balloon pulmonary angioplasty (BPA) has emerged as an effective treatment for chronic thromboembolic pulmonary hypertension (CTEPH). Recent studies have reported progressive improvements in hemodynamic and clinical parameters during follow‐up, even without additional interventions.
Wenjie Dong +8 more
wiley +1 more source