Results 11 to 20 of about 4,400 (309)
Digestion, 1998 Accessible online at: http://BioMedNet.com/karger Hyperdynamic circulation as well as increased hepatic resistance contribute to portal hypertension in cirrhosis of the liver [1]. Hyperdynamic circulation with increased cardiac output, heart rate and plasma volume and decreased arterial blood pressure and systemic vascular resistance are characteristic
Alexander L. Gerbes +5 more
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Endothelins: Vasoactive Peptids [PDF]
Namık Kemal Tıp Dergisi, 2013 Local endocrine factors (autacoids, paracrine agents), which are secreted from vessel’s endothelium, provide to arrange of vascular tonus. Some of these factors cause vessel relaxation (vasodilator) such as nitric oxide (NO) and prostaglandin-I2 (PGI2 ...
Hasan Erdoğan +2 more
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Pharmacological Reviews, 2016 The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1 and -2 activate two G-protein coupled receptors, ETA and ETB, with equal affinity, whereas endothelin-3 has a lower affinity for the ETA subtype. Genes encoding the peptides are present only among vertebrates.
Davenport, Anthony P +8 more
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Cellular and Molecular Life Sciences, 2010 Endothelin-1 is the most potent vasoconstrictor agent currently identified, and it was originally isolated and characterized from the culture media of aortic endothelial cells. Two other isoforms, termed endothelin-2 and endothelin-3, were subsequently identified, along with structural homologues isolated from the venom of Actractapis engaddensis known
Kawanabe, Yoshifumi, Nauli, Surya M.
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Endothelin and endothelin antagonists in chronic kidney disease [PDF]
Kidney International, 2014 The incidence and prevalence of chronic kidney disease (CKD), with diabetes and hypertension accounting for the majority of cases, is on the rise, with up to 160 million individuals worldwide predicted to be affected by 2020. Given that current treatment options, primarily targeted at the renin-angiotensin system, only modestly slow down progression to
Kohan, Donald E., Barton, Matthias
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Expression of Endothelins and Their Receptors in Nonmelanoma Skin Cancers [PDF]
, 2006 BACKGROUND: Endothelins are paracrine peptides with growth-promoting and vasoactive functions for a variety of cell types. Elevated activation of the endothelin signaling pathway induces cell proliferation and/or survival and is implicated in a variety ...
Zhou, Youwen +6 more
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Endothelins, peptides with potent vasoactive properties, are produced by human macrophages. [PDF]
, 1990 Endothelins are peptides, originally isolated from endothelial cells, with potent vasoactive and mitogenic properties. In this study, we demonstrate that human macrophages synthesize and secrete endothelins.
Ehrenreich, Hannelore +17 more
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European Journal of Medical Research, 2009 Objective Numerous reports have shown the influence of renin, nitric oxide (NO) and the endothelin (ET) systems for regulation of blood pressure and renal function. Furthermore, interactions between these peptides have been reported. Aim of our study was
Reinhold SW +8 more
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Methodist DeBakey Cardiovascular Journal, 2023 Vasoplegia is a condition characterized by persistent low systemic vascular resistance despite a normal or high cardiac index, resulting in profound and uncontrolled vasodilation. Vasoplegia may occur due to various conditions, including cardiac failure,
Iqbal Ratnani +3 more
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Endothelin and menstruation [PDF]
Human Reproduction, 1996 Endothelin (ET) and its mRNA are present in human endometrium. Its expression varies across the menstrual cycle, reaching maximal levels in the pre-menstrual phase. Human endometrial epithelial cells are the major in-vitro source of ET, and its release is affected by the stage of the menstrual cycle from which the endometrium is taken and by the ...
M M, Marsh +2 more
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