Results 31 to 40 of about 37,353 (347)
Life Sciences, 2014 Twenty-five years ago, a groundbreaking paper from Tsukuba University in Japan was published, identifying the sequence of the endothelin gene and peptide (Nature 332, 411-415, 1988). This work opened the way for the discovery of the endothelin receptors and the development of orally active endothelin receptor antagonists (ERAs). Today, ERAs are part of
Emoto, N +4 more
openaire +4 more sources
Novel pathways of heart failure with preserved ejection fraction [PDF]
, 2016 INTRODUCTION: Diastolic heart failure (HF) i.e., HF with preserved ejection fraction (HFpEF) accounts for ~50% of all clinical HF presentations; but unlike systolic HF i.e., HF with reduced ejection fraction (HFrEF), there are no evidenced based ...
Li, Shanpeng
core +2 more sources
Pharmacological Potential of Endothelin Receptors Agonists and Antagonists
Acta Medica, 2005 Endothelins are potent predominantly vasoconstricting agents that act as local autocrine and paracrine mediators. Endothelin-1 is the most potent and sustained vasoconstrictor and pressor substance yet identified.
Jiří Patočka +3 more
doaj +1 more source
Insights into Endothelin-3 and Multiple Sclerosis
Biomolecular Concepts, 2020 Endothelins are powerful vasoconstrictor peptides that play numerous other roles. Endothelin-1 (ET1) is the principal isoform produced by the endothelium in the human cardiovascular system.
Monti Lucia +2 more
doaj +1 more source
Tetramethylenedisulfotetramine [PDF]
, 2014 Tetramethylenedisulfotetramine (CAS 80-12-6), commonly referred to as TETS, was first synthesized in 1933 as a condensation product of sulfamide and formaldehyde. TETS was subsequently used as a rodenticide until banned worldwide in 1991.
Banks, CN +3 more
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CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Early survival factor deprivation in the olfactory epithelium enhances activity-dependent survival
Frontiers in Cellular Neuroscience, 2013 The neuronal olfactory epithelium undergoes permanent renewal because of environmental aggression. This renewal is partly regulated by factors modulating the level of neuronal apoptosis.
Adrien eFrançois +17 more
doaj +1 more source
An Integrated Pathogenetic Model of Primary Biliary Cholangitis
LiversThe pathogenesis of primary biliary cholangitis (PBC) is not fully understood. Despite recent progress, many aspects require further clarification. Thus, PBC is regarded as an autoimmune disease, but immunosuppressive treatment, which is effective in ...
Elias Kouroumalis +2 more
doaj +1 more source
Endothelin-1 Production by Normal Human Cultured Keratinocytes and its Regulation
Mediators of Inflammation, 1994 The possibility that cultured keratinocytes produce endothelins were investigated. The results showed that cultured keratinocytes derived from normal human skin produce endothelin-1. Moreover, keratinocyte endothelin-1 production was completely inhibited
Hajime Inoue +7 more
doaj +1 more source
Renal failure in experimental sepsis: role of Endothelin and the Toll-like receptor 4 [PDF]
, 2011 Sepsis is the leading cause of renal failure in critically ill patients, but the pathogenesis of septic kidney dysfunction is poorly defined. The current paradigm states that hypoperfusion and excessive renal vasoconstriction results in renal ischemia.
Fenhammar, Johan
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