Results 51 to 60 of about 37,353 (347)
Roles of Astrocytic Endothelin ETB Receptor in Traumatic Brain Injury
Cells, 2023 Traumatic brain injury (TBI) is an intracranial injury caused by accidents, falls, or sports. The production of endothelins (ETs) is increased in the injured brain.
Shotaro Michinaga +2 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.AngioPlate384 is a 384‐well open‐top platform that automates production of more than 100 miniaturized, perfusable blood vessels embedded in hydrogel and supported by stromal cells. Stromal‐endothelial co‐culture strengthens blood vessel barrier function and yields responses useful for translational planning. Scalable and automation‐ready, it suits drug
Dawn S. Y. Lin +14 more
wiley +1 more source
Frontiers in Pharmacology, 2015 Orphan G protein-coupled receptors (GPCRs) represent a largely untapped resource for the treatment of a variety of diseases, despite sophisticated advances in drug discovery.
Nicola J Smith, Nicola J Smith
doaj +1 more source
Can we continue research in splenectomized dogs? Mycoplasma haemocanis: Old problem - New insight [PDF]
, 2004 We report the appearance of a Mycoplasma haemocanis infection in laboratory dogs, which has been reported previously, yet, never before in Europe. Outbreak of the disease was triggered by a splenectomy intended to prepare the dogs for a hemorrhagic shock
A. Schropp +35 more
core +1 more source
Advanced Materials Technologies, EarlyView.This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang +4 more
wiley +1 more source
New England Journal of Medicine, 1995 Based on the data from current literature a survey of the new endothelial cell derived peptides endothelins and their characteristics are given. Having the most and longest vasoconstrictor activity that has been described to date and ability to stimulate the release aldosterone, catecholamine and renin, endothelin-1 became the subject of many studies ...
openaire +4 more sources
Investigation of the Molecular Mechanisms by Which Endothelin-3 Stimulates Preadipocyte Growth
Frontiers in Endocrinology, 2021 Endothelins induce many biological responses, and they are composed of three peptides: ET-1, ET-2, and ET-3. Reports have indicated that ET-1 regulates cell proliferation, adipogenesis, and other cell responses and that ET-3 stimulates the growth of ...
An-Ci Siao +14 more
doaj +1 more source
NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction
Advanced Science, EarlyView.NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu +15 more
wiley +1 more source
Frontiers in Cardiovascular Medicine, 2022 BackgroundLeft ventricular (LV) remodeling consists in maladaptive changes in cardiac geometry and function following an insult such as ST-segment elevation myocardial infarction (STEMI).
Oriol Iborra-Egea +15 more
doaj +1 more source
Identification of endothelin-1, endothelin-2 and endothelin-3 in human endometrium [PDF]
Reproduction, 1993 This study determined the presence of specific endothelin isoforms in human endometrium using high performance liquid chromatography (HPLC) combined with radioimmunoassay, and immunocytochemistry to detect the endothelin precursors (proendothelin-1, proendothelin-2 and proendothelin-3).
I T, Cameron +5 more
openaire +2 more sources