Results 21 to 30 of about 981,494 (350)

Hypothalamic GABAergic neurocircuitry in the regulation of energy homeostasis and sleep/wake control

open access: yesMedical Review, 2022
Gamma-aminobutyric acid (GABAergic) neuron, as one of important cell types in synaptic transmission, has been widely involved in central nervous system (CNS) regulation of organismal physiologies including cognition, emotion, arousal and reward. However,
Jiang Hong
doaj   +1 more source

Regulation of genes involved in carnitine homeostasis by PPARa across different species (rat, mouse, pig, cattle, chicken, and human) [PDF]

open access: yes, 2012
Recent studies in rodents convincingly demonstrated that PPAR-alpha is a key regulator of genes involved in carnitine homeostasis, which serves as a reasonable explanation for the phenomenon that energy deprivation and fibrate treatment, both of which ...
Egeri, Leonie   +4 more
core   +1 more source

Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight [PDF]

open access: yes, 2016
Despite clear associations between vitamin D deficiency and obesity and/or type 2 diabetes, a causal relationship is not established. Vitamin D receptors (VDRs) are found within multiple tissues, including the brain.
Arble, Deanna M.   +9 more
core   +4 more sources

Nicotinic Regulation of Energy Homeostasis [PDF]

open access: yesNicotine & Tobacco Research, 2012
The ability of nicotine, the primary psychoactive substance in tobacco smoke, to regulate appetite and body weight is one of the factors cited by smokers that prevents them from quitting and is the primary reason for smoking initiation in teenage girls.
ZOLI, Michele, Picciotto, MR
openaire   +3 more sources

A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]

open access: yes, 2010
This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Groen, A.K.   +3 more
core   +3 more sources

Mathematical models of energy homeostasis [PDF]

open access: yesJournal of The Royal Society Interface, 2008
Diabetes and obesity present a mounting global challenge. Clinicians are increasingly turning to mechanism-based mathematical models for a quantitative definition of physiological defects such as insulin resistance, glucose intolerance and elevated obesity set points, and for predictions of the likely outcomes of therapeutic interventions.
Ratchada, Pattaranit   +1 more
openaire   +2 more sources

Exploring Extracellular Vesicles Biogenesis in Hypothalamic Cells through a Heavy Isotope Pulse/Trace Proteomic Approach

open access: yesCells, 2020
Studies have shown that the process of extracellular vesicles (EVs) secretion and lysosome status are linked. When the lysosome is under stress, the cells would secrete more EVs to maintain cellular homeostasis.
Chee Fan Tan   +7 more
doaj   +1 more source

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. [PDF]

open access: yes, 2019
Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often beneficial to energy expenditure; however, increased circulating levels of BCAA are linked to obesity and diabetes.
A Balkow   +72 more
core   +1 more source

Brain circuits regulating energy homeostasis [PDF]

open access: yesRegulatory Peptides, 2008
Recent years have seen an impetus in the study for central mechanisms regulating energy balance, and caloric intake possibly as a response to the obesity pandemic. This renewed interest as well as drastic improvements in the tools that are now currently available to neuroscientists, has yielded a great deal of insight into the mechanisms by which the ...
Alfonso, Abizaid, Tamas L, Horvath
openaire   +2 more sources

Rna M6a Methylation Regulates Glycolysis of Beige Fat and Contributes to Systemic Metabolic Homeostasis

open access: yesAdvanced Science, 2023
N6‐methyladenosine (m6A) modification has been implicated in the progression of obesity and metabolic diseases. However, its impact on beige fat biology is not well understood.
Yu Li   +16 more
doaj   +1 more source

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