Results 21 to 30 of about 4,215 (171)

Estudio y manejo de las neuropatías de fibra fina

Kranion, 2022
La neuropatía de fibra fina es una entidad frecuentemente infradiagnosticada que puede deberse a numerosas causas. La sintomatología más habitual la conforman alteraciones de la sensibilidad y el dolor, síntomas disautonómicos como la taquicardia ...
Juan Carlos Gómez Esteban, Beatriz Tijero Merino, Sara Teijeira-Portas, Naiara Azkue   +3 more
doaj   +1 more source

Expression of the Adenosine A_2A-A₃ Receptor Heteromer in Different Brain Regions and Marked Upregulation in the Microglia of the Transgenic APP_Sw,Ind Alzheimer’s Disease Model

Biomedicines, 2022
Adenosine (Ado) receptors have been instrumental in the detection of heteromers and other higher-order receptor structures, mainly via interactions with other cell surface G-protein-coupled receptors.
Alejandro Lillo, Iu Raïch, Jaume Lillo, Catalina Pérez-Olives, Gemma Navarro, Rafael Franco   +5 more
doaj   +1 more source

CALBINDIN CONTENT AND DIFFERENTIAL VULNERABILITY OF MIDBRAIN EFFERENT DOPAMINERGIC NEURONS IN MACAQUES

Frontiers in Neuroanatomy, 2014
Calbindin (CB) is a calcium binding protein reported to protect dopaminergic neurons from degeneration. Although a direct link between CB content and differential vulnerability of dopaminergic neurons has long been accepted, factors other than CB have ...
Iria G Dopeso-Reyes, Iria G Dopeso-Reyes, Alberto J Rico, Alberto J Rico, Elvira eRoda, Elvira eRoda, Salvador eSierra-San Nicolas, Salvador eSierra-San Nicolas, Diego ePignataro, Diego ePignataro, Maria eLanz, Diego eSucunza, Luis eChang-Azancot, Jose L Lanciego, Jose L Lanciego   +14 more
doaj   +1 more source

Creutzfeldt-Jakob disease in Peru: report of eleven cases

Revista Peruana de Medicina Experimental y Salud Pública, 2014
Creutzfeldt-Jakob disease (CJD) is a fatal neurological disease caused by pathological isoform of the human prion protein. Clinical features of six cases of the sporadic form of CJD with definitive diagnosis by histopathology, and five cases with ...
Luis Torres-Ramírez, Jorge Ramírez-Quiñones, Carlos Cosentino-Esquerre, Miriam Vélez-Rojas, Martha Flores-Mendoza, Diana Rivas-Franchini, Rafael Suarez-Reyes, Yesenia Núñez-Coronado   +7 more
doaj   +1 more source

Additional mechanisms conferring genetic susceptibility to Alzheimer's disease

Frontiers in Cellular Neuroscience, 2015
Familial Alzheimer's disease (AD), mostly associated with early onset, is caused by mutations in three genes (APP, PSEN1 and PSEN2) involved in the production of the amyloid  peptide.
Miguel eCalero, Miguel eCalero, Miguel eCalero, Alberto eGomez-Ramos, Alberto eGomez-Ramos, Olga eCalero, Olga eCalero, Eduardo eSoriano, Eduardo eSoriano, Jesus eAvila, Jesus eAvila, Miguel eMedina, Miguel eMedina   +12 more
doaj   +1 more source

Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain

BMC Biology, 2018
Background G-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities.
Gemma Navarro, Arnau Cordomí, Marc Brugarolas, Estefanía Moreno, David Aguinaga, Laura Pérez-Benito, Sergi Ferre, Antoni Cortés, Vicent Casadó, Josefa Mallol, Enric I. Canela, Carme Lluís, Leonardo Pardo, Peter J. McCormick, Rafael Franco   +14 more
doaj   +1 more source

Angiotensin AT1 and AT2 receptor heteromer expression in the hemilesioned rat model of Parkinson’s disease that increases with levodopa-induced dyskinesia

Journal of Neuroinflammation, 2020
Background/aims The renin-angiotensin system (RAS) is altered in Parkinson’s disease (PD), a disease due to substantia nigra neurodegeneration and whose dopamine-replacement therapy, using the precursor levodopa, leads to dyskinesias as the main side ...
Rafael Rivas-Santisteban, Ana I. Rodriguez-Perez, Ana Muñoz, Irene Reyes-Resina, José Luis Labandeira-García, Gemma Navarro, Rafael Franco   +6 more
doaj   +1 more source

Identification of Heteroreceptors Complexes and Signal Transduction Events Using Bioluminescence Resonance Energy Transfer (BRET)

Bio-Protocol, 2019
Detecting protein-protein interactions by co-immunoprecipitation provided a major advancement in the immunology research field. In the G-protein-coupled receptors (GPCRs) research field, colocalization and co-immunoprecipitation were used to detect ...
Irene Reyes-Resina, Jasmina Jiménez, Gemma Navarro, Rafael Franco   +3 more
doaj   +1 more source

Differential Progression of Neuroinflammation in Patients with Isolated Rapid‐Eye‐Movement Sleep Behavior Disorder

Movement Disorders, EarlyView.
Abstract Background Neuroinflammation, measured using [11C](R)‐PK11195 positron emission tomography (PET), has been reported in isolated rapid‐eye‐movement sleep behavior disorder (iRBD), but its temporal progression is unknown. Objective The aim was to assess longitudinal progression of neuroinflammation in iRBD patients and its relationship with ...
Andreas Myhre Baun, Alex Iranzo, Miriam Højholt Terkelsen, Rainer Hinz, Morten Gersel Stokholm, Kristian Stær, Mónica Serradel, Marit Otto, Kristina Bacher Svendsen, Alicia Garrido, Dolores Vilas, Arne Møller, Carles Gaig, Eduardo Tolosa, David J. Brooks, Per Borghammer, Simon Fristed Eskildsen, Nicola Pavese   +17 more
wiley   +1 more source

Transmembrane amyloid-related proteins in CSF as potential biomarkers for Alzheimer’s disease

Frontiers in Neurology, 2015
In the continuing search for new cerebrospinal fluid (CSF) biomarkers for Alzheimer’s disease (AD), reasonable candidates are the secretase enzymes involved in the processing of the amyloid precursor protein (APP), as well as the large proteolytic ...
Inmaculada eLopez-Font, Inmaculada eLopez-Font, Inmaculada eCuchillo-Ibañez, Inmaculada eCuchillo-Ibañez, Aitana eSogorb-Esteve, Aitana eSogorb-Esteve, María-Salud eGarcía-Ayllón, María-Salud eGarcía-Ayllón, María-Salud eGarcía-Ayllón, Javier eSáez-Valero, Javier eSáez-Valero   +10 more
doaj   +1 more source