Results 41 to 50 of about 4,215 (171)
Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands
ChemMedChem, Volume 21, Issue 13, 14 July 2026.Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...Maria‐Eleni Kouridaki, Mercè Pallàs, Carmen Escolano +2 morewiley +1 more sourceNeurobanco del grupo de Neurociencias de Antioquia
Iatreia, 2005 El material biológico procedente de personas afectadas por enfermedades neurodegenerativas y el de controles sanos, es una necesidad para la investigación de las enfermedades neurodegenerativas.Francisco Javier Lopera Restrepo, Amanda Saldarriaga, Diego Sepúlveda, Carlos A. Villegas, Gloria García +4 moredoaj New Features about Tau Function and Dysfunction
Biomolecules, 2016 Tau is a brain microtubule-associated protein that directly binds to a microtubule and dynamically regulates its structure and function. Under pathological conditions, tau self-assembles into filamentous structures that end up forming neurofibrillary ...Miguel Medina, Félix Hernández, Jesús Avila +2 moredoaj +1 more sourceUnveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy
Alzheimer's &Dementia, Volume 22, Issue 7, July 2026. Abstract INTRODUCTION
A subset of Alzheimer's disease (AD) patients exhibits a procoagulant state that remains undiagnosed despite available treatments. We developed positron emission tomography (PET) strategies to in vivo detect cerebral microthrombi in TgCRND8 mice. METHODS
PET was performed with a fibrin‐binding probe (FBP) in TgCRND8 and wild‐type Carlos Ceron, Marta Casquero‐Veiga, Nicolás Lamanna‐Rama, Irene Fernández‐Nueda, Alberto Fernández‐Pena, Nancy Olazagoitia, Gorka Sobrino, Aitor Herraiz, María Isabel González, María Muñoz‐Hernando, Alejandro Ruperti‐Repilado, Eduardo Romero‐Sanz, Miguel Ángel Morcillo, Carlos Pérez‐Medina, Maria Angeles Moro, Gonzalo Villaverde, Jorge Rubio, Jose Fernandez‐Ferro, Manuel Desco, Fernando Herranz, Beatriz Salinas, Valentin Fuster, Marta Cortes‐Canteli +22 morewiley +1 more sourceTau protein and adult hippocampal neurogenesis
Frontiers in Neuroscience, 2012 Tau protein is a microtubule associated protein found in the axonal compartment that stabilizes neuronal microtubules under normal physiological conditions.Almudena eFuster-Matanzo, Almudena eFuster-Matanzo, María eLlorens-Martín, María eLlorens-Martín, Jerónimo eJurado-Arjona, Jerónimo eJurado-Arjona, Jesus eAvila, Jesus eAvila, Félix eHernández, Félix eHernández +9 moredoaj +1 more sourceNeuropsychiatric Adverse Events Associated With Foslevodopa/Foscarbidopa Continuous Subcutaneous Infusion in Clinical Practice: A Multicenter Study
European Journal of Neurology, Volume 33, Issue 7, July 2026.In 214 patients with advanced Parkinson's disease receiving foslevodopa/foscarbidopa continuous subcutaneous infusion, neuropsychiatric adverse events occurred in 19.2%. Baseline cognitive impairment and hallucinations did not increase risk, whereas preexisting impulse control disorders predicted ICD‐related adverse events.David Campo‐Caballero, Jon Rodriguez‐Antiguedad, Arnau Puig‐Davi, Javier Ruiz‐Martinez, Ana Vinagre‐Aragón, Elisabet Mondragón, Lara Pardina Vilella, Nuria López‐Ariztegui, Nuria Caballol, Guillermo González‐Ortega, Iria Cabo, Rocío García Ramos, Inés Legarda, Marta Blázquez‐Estrada, Pilar Sánchez‐Alonso, Pablo Mir, Juan Carlos Romero Fábrega, Silvia Martí Martinez, María Álvarez Sauco, Diego Santos‐García, DATs‐PD GETM Spanish Registry Group, Nuria López Ariztegui, Maria Isabel Morales Casado, Guillermo Tabar Comellas, Asunción Ávila Rivera, Núria Caballol Pons, Anna Planas‐Ballvé, Alejandro Peral Quirós, Dolors Lozano, Diego Santos García, Jose Manuel Paz González, Carlos Cores Bartolomé, Lucia Belen Samaniego Vinueza, Ángela Solleiro Vidal, Iria Cabo, Alejandro Rivero de Aguilar Pensado, Rocío García Ramos, Ana Fernández Revuelta, Eva López Valdés, Ana Aldaz, Carmen Ribacoba Díaz, Inés Legarda Ramírez, Bàrbara Vives Pastor, María Fuensanta Valero García, Marta Blázquez Estrada, Esther Suárez San Martín, Ciara García Fernández, Pilar Tartiere, Patricia Prendes Fernández, Pilar Sánchez‐Alonso, Sabela Novo Ponte, Elisa Gamo González, Raquel Martín García, Pablo Mir Rivera, Laura Muñoz Delgado, Astrid Daniela Adarmes Gómez, Elena Ojeda Lepe, Silvia Jesús Maestre, Daniel Macías García, Fátima Carrillo García, Ana María Castellano Guerrero, Manuela San Eufrasio Martínez, Cristina Pérez Calvo, María López González, Andrés García Herruzo, Cristina Gómez Rapela, Lorena Garrote Espina, Natalia González Rojas, Juan Carlos Romero Fábrega, Francisco Escamilla Sevilla, Lucía Triguero Cueva, Carlos Javier Madrid Navarro, Silvia Martí Martínez, María Álvarez Sauco, Eric Freire Álvarez, Jessica González Ardura, Belén Castaño García, Antonio Sánchez Rodríguez, Déborah Alonso Modino, Jesús Norelis Lorenzo Brito, Maria Esther Rojas Pérez, Carolina Hernández Javier, Jorge Hernández Vara, Maria Victoria González, Sara Belmonte, Débora María Cerdán Santacruz, Amelia Mendoza Rodríguez, Ana Castrillo Sanz, Lorena Caballero Sánchez, Claudia Gómez López de San Román, Álvaro Sánchez‐Ferro, Pablo Rábano Suárez, Antonio Méndez Guerrero, Daniel Pérez Rangel, Jesús Ramírez, Cristina del Álamo Criado, Javier Ruíz Martínez, Elisabet Mondragón Rezola, Ana Vinagre Aragón, Lara Pardina Vilella, David Campo Caballero, Ana Belén Perona Moratalla, Gustavo Fernández‐Pajarín, Maria Pilar Gil Villar, Agustín Sancho Saldana, Laura Quibus Requena, Ángela Monterde Ortega, Juan Carlos Gómez Esteban, Tamara Fernández Valle, Marta Ruiz López, Beatriz Tijero Merino, Susana Cantarero Duque, Guillermo González‐Ortega, Esther Cubo Delgado, Beatriz Alegre García, Lydia López Manzanares, Inés Muro, Elena Casas Peña, Pablo Lorenzo Barreto, Emma Cañada Lahoz, Sara Lozano Veiga, Lydia Vela, Irene Martínez‐Torres, Carlos Morata‐Martínez, Raquel Baviera‐Muñoz, Marina Campins Romeu, Isabel Sastre Bataller, Elena Navarro Mocholí, Roberto López Blanco, Sonia Escalante Arroyo, Tania Delgado Ballestero +130 morewiley +1 more sourceRol del eje tirotrópico en enfermedades neurodegenerativas
Correo Científico Médico, 2013
Las hormonas tiroideas actúan como reguladores primarios del metabolismo intermediario en todos los tejidos del organismo; tienen funciones de gran trascendencia a nivel del sistema nervioso, donde ejercen acciones potencialmente neuroprotectoras.Yudelkis Cutié Anido, Amarilis Álvarez Sosa, Dennis Almaguer Gotay, Raúl Aguilera Rodríguez, Luis Enrique Almaguer Mederos +4 moredoaj Improving the clinical trial landscape for patients with atypical variants of Alzheimer's disease: a call to action
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract
Patients with atypical variants of Alzheimer's disease (AD) often present at a younger age with predominantly non‐amnestic impairments and a more aggressive disease course. Historically, individuals with atypical presentations have not been included in large‐scale clinical trials, which typically focus on late‐onset, sporadic amnestic ...Nick Corriveau‐Lecavalier, Neus Falgàs, Deepti Putcha, Jonathan Graff‐Radford, Keir X. X. Yong, Baayla D. C. Boon, Rosaleena Mohanty, Eric Westman, Colin Groot, David T. Jones, Lea T. Grinberg, Gil D. Rabinovici, Jennifer L. Whitwell, Liana G. Apostolova, Melissa E. Murray, Dustin B. Hammers, Suzanne E. Schindler, Inga Atonsdottir, Elizabeth K. Rhodus, Jonathan M. Schott, Ignacio Illán‐Gala, Chukwuanugo Ogbuagu, Jorge J. Llibre Guerra, Ruth Peters, Erin L. Abner, Carla Abdelnour, Albert Lladó, Renaud La Joie, Leonardo Cruz de Souza, Neguine Rezaii, Dror Shir, Yolande A. L. Pijenburg, Maria C. Carrillo, Bradford C Dickerson, Paul Aisen, Rik Ossenkoppele, Rema Raman +36 morewiley +1 more sourceESPINA: a tool for the automated segmentation and counting of synapses in large stacks of electron microscopy images
Frontiers in Neuroanatomy, 2011 The synapses in the cerebral cortex can be classified into two main types, Gray’s type I and type II, which correspond to asymmetric (mostly glutamatergic excitatory) and symmetric (inhibitory GABAergic) synapses, respectively.Juan eMorales, Juan eMorales, Lidia eAlonso-Nanclares, Lidia eAlonso-Nanclares, Lidia eAlonso-Nanclares, José-Rodrigo eRodriguez, José-Rodrigo eRodriguez, José-Rodrigo eRodriguez, Javier eDefelipe, Javier eDefelipe, Javier eDefelipe, Ángel eRodriguez, Angel eMerchan-Perez, Angel eMerchan-Perez, Angel eMerchan-Perez +14 moredoaj +1 more sourcePrevalence of high‐risk plasma p‐tau217 levels and 5‐year transition of risk status in 70‐year‐olds
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION
High‐risk plasma p‐tau217 levels predict amyloid‐β pathology in Alzheimer's disease, but little is known about the prevalence and temporal dynamics in the general population. METHODS
Participants from the Gothenburg H70 Birth Cohort Study in Sweden were examined (n = 1157) and re‐examined after 5–7 years (n = 771).Anna Dittrich, Burak Arslan, Tobias Skillbäck, Lina Rydén, Hlin Kvartsberg, Johan Gobom, Kaj Blennow, Henrik Zetterberg, Silke Kern, Ingmar Skoog +9 morewiley +1 more source
