Results 51 to 60 of about 19,000 (208)
New Features about Tau Function and Dysfunction
Biomolecules, 2016 Tau is a brain microtubule-associated protein that directly binds to a microtubule and dynamically regulates its structure and function. Under pathological conditions, tau self-assembles into filamentous structures that end up forming neurofibrillary ...
Miguel Medina +2 more
doaj +1 more source
Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease
European Journal of Neuroscience, Volume 63, Issue 9, May 2026.Microglia are dynamic, context‐dependent regulators of Alzheimer's disease, modulating amyloid, tau, and neurodegeneration across disease stages. Integrating multiscale and human‐focused approaches is essential to translate microglial biology into therapeutic strategies. ABSTRACT Microglia, the resident innate immune cells of the central nervous system,
Patricia Martínez‐Tazo +9 more
wiley +1 more source
Tau protein and adult hippocampal neurogenesis
Frontiers in Neuroscience, 2012 Tau protein is a microtubule associated protein found in the axonal compartment that stabilizes neuronal microtubules under normal physiological conditions.
Almudena eFuster-Matanzo +9 more
doaj +1 more source
Determinación de compuestos del aceite de oliva virgen relacionados con enfermedades cancerígenas y neurodegenerativas [PDF]
, 2019 El aceite de oliva virgen (AOV) es el zumo extraído del fruto del olivo, uno de los alimentos más populares y recomendados en el marco de una dieta saludable.
Salas Arias, Tania
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A Renal Clearable Probe for In Vivo Monoamine Oxidase (MAO) Detection
Advanced Science, Volume 13, Issue 23, 23 April 2026.A renal‐clearable Cy7‐based fluorogenic probe enables rapid and non‐invasive detection of monoamine oxidase (MAO) activity in vivo. Upon MAO‐mediated activation, the fluorescent product is efficiently excreted in urine, allowing direct quantification of enzyme overexpression.
Marcia Domínguez +13 more
wiley +1 more source
Rol del eje tirotrópico en enfermedades neurodegenerativas
Correo Científico Médico, 2013 Las hormonas tiroideas actúan como reguladores primarios del metabolismo intermediario en todos los tejidos del organismo; tienen funciones de gran trascendencia a nivel del sistema nervioso, donde ejercen acciones potencialmente neuroprotectoras.
Yudelkis Cutié Anido +4 more
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Neurotoxicidad de los organofosforados y su interacción con enfermedades degenerativas [PDF]
, 2013 El Alzhéimer es una enfermedad neurodegenerativa que se manifiesta como deterioro cognitivo y trastornos conductuales. Se caracteriza en su forma típica por una pérdida inmediata de la memoria y otras capacidades mentales, a medida que las células ...
Rueda García, Patricia
core +1 more source
A harmonized framework for studying exceptional cognitive aging in Latin America
Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Abstract INTRODUCTION Biological, genetic, and sociocultural factors underlying cognitive resilience and resistance to pathology remain unexplored in Latin America. The Life‐Course Epidemiology of Aging, Resilience, and Neurodegeneration in Alzheimer's Disease (LEARN‐AD) study and Latin American SuperAgers Study (LASAS) establish the first harmonized ...
Lucia Crivelli +20 more
wiley +1 more source
Frontiers in Neuroanatomy, 2011 The synapses in the cerebral cortex can be classified into two main types, Gray’s type I and type II, which correspond to asymmetric (mostly glutamatergic excitatory) and symmetric (inhibitory GABAergic) synapses, respectively.
Juan eMorales +14 more
doaj +1 more source
Increased Impulsivity following progressive nigral degenereation and chronic pramipexole treatment in an animal model of Parkinson's disease [PDF]
, 2017 Dopamine agonists (DA) that are widely used to treat motor deficits in patients with Parkinson’s disease (PD) are frequently associated with the development of abnormal-impulsive behaviors (AIB).
Delgado-Alvarado, Manuel +6 more
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