Results 71 to 80 of about 19,000 (208)
Neurología (English Edition), 2015 Introduction: Parkinson's disease affects the quality of life of the individual with the disease in addition to creating a burden on the caregiver. Factors related to these effects include motor and non-motor aspects of the disease, as well as traits ...
M. Rodríguez-Violante +4 more
doaj +1 more source
Derivados de 1,4,5-dibenzo[b,f]tiadiazepinas 5,6-dihidro y su uso en el tratamiento de enfermedades neurodegenerativas [PDF]
, 2008 Derivados de 1,4,5-dibenzo[b,f]tiadiazepinas 5,6-dihidro y su uso en el tratamiento de enfermedades neurodegenerativas. Compuestos químicos derivados del sistema heterocíclico 1,4,5-dibenzo[b,f]tiadiazepinas 5,6-dihidro y su uso como composiciones ...
Conde, Santiago +5 more
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European Journal of Neurology, Volume 33, Issue 3, March 2026.ABSTRACT Background There is an unmet need for the clinically relevant ALS biomarkers to facilitate an accurate diagnosis in suspected cases, monitor disease progression and evaluate response to therapy in clinical trials. While the MND/ALS literature is dominated by innovative brain studies, motor disability in ALS is primarily driven by neurogenic ...
Alison Toomey +4 more
wiley +1 more source
Heterocyclic GSK-3 allosteric modulators [PDF]
, 2011 [ES] La presente invención se refiere a derivados heterocíclicos de quinolinas sustituidas como inhibidores alostéricos del enzima glucógeno sintasa quinasa 3 (GSK-3).
Gil, Carmen +4 more
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Journal of the American Geriatrics Society, Volume 74, Issue 3, Page 854-867, March 2026.ABSTRACT Introduction Although frailty is considered a potentially modifiable risk factor for dementia, its influence on health outcomes in individuals with established dementia remains unclear. This study aims to systematize the current evidence to understand the impact of frailty on the development of adverse outcomes in older adults with dementia ...
Miguel German Borda +11 more
wiley +1 more source
Alzheimer’s disease as an inflammatory disease
Biomolecular Concepts, 2017 Alzheimer’s disease (AD) is a neurodegenerative condition characterized by the formation of amyloid-β plaques, aggregated and hyperphosphorylated tau protein, activated microglia and neuronal cell death, ultimately leading to progressive dementia.
Bolós Marta +2 more
doaj +1 more source
The involvement of cholinergic neurons in the spreading of tau pathology
Frontiers in Neurology, 2013 Long time ago, it was described the selective loss of cholinergic neurons during the development of Alzheimer disease. Recently, it has been suggested that tau protein may play a role in that loss of cholinergic neurons through a mechanism involving the ...
Diana eSimon +5 more
doaj +1 more source
Bases Moleculares de la Enfermedad de Alzheimer [PDF]
, 2018 La enfermedad de Alzheimer es el tipo más frecuente de demencia senil y constituye un grave problema de salud pública desde hace varios años, con una importancia creciente conforme aumenta la edad media y la esperanza de vida de la población.
Gutiérrez Antoñanzas, Juan Carlos
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Enfermedades neurodegenerativas: Alzehimer-Parquinson
, 2021 Antes de comenzar con la descripción del Síndrome de Alzheimer y la enfermedad de Parkinson,debemos mencionar algunas generalidades comunes a las enfermedades neurodegenerativas.Estas son un grupo de enfermedades que afectan al sistema nervioso central, siendo doscaracterísticas importantes la naturaleza degenerativa y el curso crónico de las mismas ...
openaire +1 more source
Insertos intranasales para dirigir moléculas activas al sistema nervioso central [PDF]
, 2019 Con motivo del auge actual acerca de los avances producidos en el tratamiento de las enfermedades neurodegenerativas, se están abarcando otras estrategias alternativas focalizadas hacia la consecución de una mayor efectividad de los tratamientos.
Martos Carrasco, Laura
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