Thermostable chaperone-based polypeptide biosynthesis: Enfuvirtide model product quality and protocol-related impurities. [PDF]
PLoS ONE, 2023 Large peptide biosynthesis is a valuable alternative to conventional chemical synthesis. Enfuvirtide, the largest therapeutic peptide used in HIV infection treatment, was synthesized in our thermostable chaperone-based peptide biosynthesis system and ...
Vladimir Zenin +4 more
doaj +4 more sources
Action of enfuvirtide on the pregnancy of albino rats ( Rattus norvegicus albinus, Rodentia, Mammalia ): biological assay and functional and histological analyses of exposed maternal-fetal organs [PDF]
Einstein (São Paulo), 2023 Objective To assess the effects of enfuvirtide on pregnancy in albino rats and their fetuses. Methods Forty pregnant EPM 1 Wistar rats were randomly allocated into four groups: control (E) (distilled water twice/day), G1 (4mg/kg/day enfuvirtide), G2 ...
Renata Delphim de Moraes +4 more
doaj +2 more sources
Research strategies of the N-peptide fusion inhibitor: a promising direction for discovering novel antivirals [PDF]
Journal of VirologyAIDS, caused by HIV-1, is a devastating condition that severely compromises the human immune system, often resulting in fatal consequences. The primary therapeutic approach for AIDS involves a combination of multiple agents, known as “cocktail therapy ...
Yan Huang +11 more
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Design of Artificial Peptide Against HIV-1 Based on the Heptad-Repeat Rules and Membrane-Anchor Strategies [PDF]
PharmaceuticalsObjective: The six-helix bundle (6-HB) is critical for HIV-1 membrane fusion. To disrupt this process, peptide inhibitors have been meticulously designed to target interactions within the 6-HB regions, thereby blocking membrane fusion and exerting ...
Jiali Zhao +11 more
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Benign fibrous histiocytoma and cutaneous amyloidosis in a patient receiving enfuvirtide injections [PDF]
JAAD Case ReportsZiyang Xu, MD, PhD +3 more
doaj +2 more sources
Drugs, 2003 Enfuvirtide is the first of a new class of drugs, the fusion inhibitors. It is a synthetic peptide which binds to the HIV glycoprotein 41 (gp41), blocking fusion of the viral and cellular membranes. HIV isolates with reduced susceptibility to enfuvirtide have been recovered from patients receiving enfuvirtide in combination with other antiretroviral ...
Toni M, Dando, Caroline M, Perry
+8 more sources
Molecules, 2022 Despite the enormous efforts made to develop other fusion inhibitors for HIV, the enfuvirtide (known as T20) peptide is the only approved HIV-1 inhibitory drug so far.
Ahmed L. Alaofi
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Impact of the HIV-1 env genetic context outside HR1-HR2 on resistance to the fusion inhibitor enfuvirtide and viral infectivity in clinical isolates. [PDF]
PLoS ONE, 2011 Resistance mutations to the HIV-1 fusion inhibitor enfuvirtide emerge mainly within the drug's target region, HR1, and compensatory mutations have been described within HR2.
Franky Baatz +12 more
doaj +1 more source
Enfuvirtide biosynthesis in thermostable chaperone-based fusion
Biotechnology Reports, 2022 Synthetic peptides are in high demand as biologically active substances. Solid phase synthesis is the primary method of peptide production. However, it has drawbacks: large amount of chemical waste and rapid increase in price with peptide length ...
Vladimir Zenin +3 more
doaj +1 more source