Results 61 to 70 of about 3,441 (189)

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, Volume 15, Issue 6, 9 February 2026.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Pharmacokinetic and pharmacodynamic determinants of early virological response to enfuvirtide-based regimens in HIV-positive patients [PDF]

, 2008
BACKGROUND: Early virological response (VR) to enfuvirtide-based salvage regimens at week 12 has been described as a predictor of long-term therapeutic success.
Hamid Hasson, Diego Aguilar Marucco, D'AVOLIO, ANTONIO, Laura Trentini, CALCAGNO, Andrea, Adriano Lazzarin, BONORA, Stefano, SCIANDRA, Mauro, Daniel Gonzalez de, DI PERRI, Giovanni, Antonella Castagna   +10 more
core  

Safety of enfuvirtide in combination with an optimized background of antiretrovirals in treatment-experienced HIV-1-infected adults over 48 weeks [PDF]

, 2005
Antiretroviral tolerability is a critical factor contributing to treatment outcome. The T-20 Versus Optimized Background Regimen Only (TORO) studies assessed the safety and efficacy of enfuvirtide in treatment-experienced HIV-1-infected patients. A total
Walmsley, Sharon, Salgo, Miklos P., Lalezari, Jacob, Eron, Joseph J., Piliero, Peter, Bertasso, Anne, Katlama, Christine, Clotet, Bonaventura, DeMasi, Ralph, Trottier, Benoit, Lange, Joep, Cohen, Calvin, Henry, Keith, Kinchelow, Tosca, Labriola-Tompkins, Emily, Montaner, Julio, Reynes, Jacques, Bourdeau, Laurence, Arastéh, Keikawus, Natale, Christopher, Drobnes, Claude, Lazzarin, Adriano, Stellbrink, Hans-Jürgen, Kuritzkes, Daniel, Hughes, Fiona, Chung, Jain, Smiley, Lynn, Guimaraes, Denise, Atkins, Belinda, Shikhman, Anna, Cooper, David, O'Hearn, Mary, Delfraissy, Jean-François, Nelson, Mark, Bader-Weder, Silvia   +34 more
core   +1 more source

Five Antiretroviral Drug Class–Resistant HIV-1 in a Treatment-Naïve Patient Successfully Suppressed with Optimized Antiretroviral Drug Selection

Journal of the International Association of Providers of AIDS Care, 2015
Transmitted HIV-1 exhibiting reduced susceptibility to protease and reverse transcriptase inhibitors is well documented but limited for integrase inhibitors and enfuvirtide.
Joseph M. Volpe PhD, Douglas J. Ward MD, Laura Napolitano MD, Pham Phung BS, Jonathan Toma BS, Owen Solberg PhD, Christos J. Petropoulos PhD, Charles M. Walworth MD   +7 more
doaj   +1 more source

Cloaked similarity between HIV-1 and SARS-CoV suggests an anti-SARS strategy

BMC Microbiology, 2003
Background Severe acute respiratory syndrome (SARS) is a febrile respiratory illness. The disease has been etiologically linked to a novel coronavirus that has been named the SARS-associated coronavirus (SARS-CoV), whose genome was recently sequenced ...
Kliger Yossef, Levanon Erez Y
doaj   +1 more source

Bindings of Enfuvirtide to SM Monolayers (HPA Chip) and Bilayers (L1 Chip). [PDF]

, 2017
Panels A and B: Sensorgrams of the binding of enfuvirtide to an SM monolayer (panel A) and bilayer (panel B). Panels C and D: Corresponding relationships between the equilibrium binding response (RUeq) and the peptide concentration (C). The data were fit
Yuanguo Cheng (218759), Ping Cao (564151), Jinjing Che (218738), Guifang Dou (696514)   +3 more
core   +1 more source

Advances and Challenges in Model‐Informed Precision Dosing of Antimicrobials for Pediatric Patients

Journal of Clinical Pharmacy and Therapeutics, Volume 2026, Issue 1, 2026.
Precision medicine has transformed healthcare by moving toward individualized treatment strategies, yet dosing optimization for pediatric patients remains a complex challenge. Therapeutic drug monitoring (TDM), a widely used practice in clinical settings, provides a foundation for achieving therapeutic goals but poses significant limitations ...
Jing Kai Lam, Xiaoyan Yang, Baharudin Ibrahim, Amirrudin Kamsin, Jinxin Zhao, S. Y. Amy Cheung, Xiaofen Liu, Jamaludin Elis, Nusaibah Abdul Rahim, Yu-Wei Lin, Zhiwen Luo   +10 more
wiley   +1 more source

Combined tipranavir and enfuvirtide use associated with higher plasma tipranavir concentrations but not with increased hepatotoxicity: sub-analysis from RESIST [PDF]

, 2007
In RESIST, enfuvirtide co-administered with ritonavir-boosted tipranavir was associated with higher plasma tipranavir concentrations, which seldom rose above those associated with an increased risk of grade 3/4 transaminase elevations.
M. Battegay, M. Kraft, J. P. Sabo, R. T. Steigbigel, S. Rusconi, D. Neubacher, M. Opravil, F. Raffi, G. Blick   +8 more
core   +1 more source

Conjugation of cholesterol to HIV-1 fusion inhibitor C34 increases peptide-membrane interactions potentiating its action. [PDF]

PLoS ONE, 2013
Recently, the covalent binding of a cholesterol moiety to a classical HIV-1 fusion inhibitor peptide, C34, was shown to potentiate its antiviral activity.
Axel Hollmann, Pedro M Matos, Marcelo T Augusto, Miguel A R B Castanho, Nuno C Santos   +4 more
doaj   +1 more source

Genotype and phenotype patterns of human immunodeficiency virus type 1 to enfuvirtide during long-term treatments [PDF]

, 2004
The human immunodeficiency virus type 1 (HIV-1) fusion inhibitor enfuvirtide has recently been introduced into clinical practice and has exhibited efficient anti-HIV-1 activity in combination with other antiretroviral agents.
Danise A, Bagnarelli P, CASTAGNA, ANTONELLA, Hasson H, Carini E, Monachetti A, Lazzarin A, Menzo S, CLEMENTI , MASSIMO   +8 more
core   +1 more source