Results 71 to 80 of about 3,437 (189)
Renal effects of non-tenofovir antiretroviral therapy in patients living with HIV
Drugs in Context, 2018 A review of literature published regarding non-tenofovir antiretroviral agents causing renal adverse effects was conducted. The literature involving renal adverse effects and antiretroviral therapy is most robust with protease inhibitors, specifically ...
Milena M McLaughlin +2 more
doaj +1 more source
, 2004 Partition of the intrinsically fluorescent HIV fusion inhibitor enfuvirtide into lipidic membranes is relatively high (DeltaG=6.6 kcal (.) mol(-1)) and modulated by cholesterol.
Viega, Salomé +3 more
core +1 more source
Navigating a 1E+60 Chemical Space of Peptide/Peptoid Oligomers
Molecular Informatics, Volume 44, Issue 1, January 2025.Herein we report a virtual library of 1E+60 members, a common estimate for the size of the drug‐like chemical space. The library consists of linear or cyclic oligomers forming molecules within the size range of peptide drugs. We demonstrate ligand‐based virtual screening using a genetic algorithm.
Markus Orsi, Jean‐Louis Reymond
wiley +1 more source
A Review of Electroanalytical Techniques for Determination of Anti-HIV Drugs
International Journal of Electrochemistry, 2011 Until now after the human immunodeficiency virus (HIV) was discovered as the then tentative aetiological agent of acquired immune deficiency syndrome (AIDS), exactly 25 anti-HIV compounds have been formally approved for clinical use in the treatment of ...
Burçin Bozal +2 more
doaj +1 more source
Virological fitness of HIV in patients with resistance to enfuvirtide
, 2007 Resistance to the HIV fusion inhibitor enfuvirtide is associated with mutations in the first heptad repeat region of gp41, but little is known of their impact on replicative fitness in vivo.
Megan Gooey (20012388) +8 more
core
, 2008 We present a model of the pharmacokinetics of enfuvirtide, a potent inhibitor of the fusion of human immunodeficiency virus type 1 (HIV-1) with target cells.
Mohanty, Utkala, Dixit, Narendra M
core
Potent suppression of HIV-1 cell attachment by Kudzu root extract
Retrovirology, 2018 There is a constant need to improve antiretrovirals against HIV since therapy is limited by cost, side effects and the emergence of drug resistance. Kudzu is a climbing vine from which the root extract (Pueraria lobata), rich in isoflavones and saponins,
S. Mediouni +12 more
doaj +1 more source
, 2008 BACKGROUND: Early virological response (VR) to enfuvirtide-based salvage regimens at week 12 has been described as a predictor of long-term therapeutic success.
Hamid Hasson +10 more
core
, 2005 Antiretroviral tolerability is a critical factor contributing to treatment outcome. The T-20 Versus Optimized Background Regimen Only (TORO) studies assessed the safety and efficacy of enfuvirtide in treatment-experienced HIV-1-infected patients. A total
Walmsley, Sharon +34 more
core +1 more source
Bindings of Enfuvirtide to SM Monolayers (HPA Chip) and Bilayers (L1 Chip).
, 2017 Panels A and B: Sensorgrams of the binding of enfuvirtide to an SM monolayer (panel A) and bilayer (panel B). Panels C and D: Corresponding relationships between the equilibrium binding response (RUeq) and the peptide concentration (C). The data were fit
Yuanguo Cheng (218759) +3 more
core +1 more source