Results 1 to 10 of about 82,708 (160)

Integrating Macrophages into Human-Engineered Cardiac Tissue [PDF]

Cells
Heart disease remains a leading cause of morbidity and mortality worldwide, necessitating the development of in vivo models for therapeutic development.
Yi Peng Zhao, Barry M. Fine
doaj   +2 more sources

Rianú: Multi-tissue tracking software for increased throughput of engineered cardiac tissue screening [PDF]

Computer Methods and Programs in Biomedicine Update, 2023
Background:: The field of tissue engineering has provided valuable three-dimensional species-specific models of the human myocardium in the form of human Engineered Cardiac Tissues (hECTs) and similar constructs.
Jack F. Murphy, Kevin D. Costa, Irene C. Turnbull   +2 more
doaj   +2 more sources

3094 Production of Engineered Cardiac Tissue for Disease Modeling [PDF]

Journal of Clinical and Translational Science, 2019
OBJECTIVES/SPECIFIC AIMS: Cardiovascular diseases (CVD) is the leading cause of death worldwide in both men and women due to lack of cardiac regeneration after disease or damaged is caused.
Morgan Ellis, Elizabeth Lipke
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Cardiac Meets Skeletal: What’s New in Microfluidic Models for Muscle Tissue Engineering [PDF]

Molecules, 2016
In the last few years microfluidics and microfabrication technique principles have been extensively exploited for biomedical applications. In this framework, organs-on-a-chip represent promising tools to reproduce key features of functional tissue units ...
Roberta Visone, Mara Gilardi, Anna Marsano, Marco Rasponi, Simone Bersini, Matteo Moretti   +5 more
doaj   +4 more sources

Macrophages enhance contractile force in iPSC-derived human engineered cardiac tissue [PDF]

Cell Reports
Summary: Resident cardiac macrophages are critical mediators of cardiac function. Despite their known importance to cardiac electrophysiology and tissue maintenance, there are currently no stem-cell-derived models of human engineered cardiac tissues ...
Roberta I. Lock, Pamela L. Graney, Daniel Naveed Tavakol, Trevor R. Nash, Youngbin Kim, Eloy Sanchez, Jr., Margaretha Morsink, Derek Ning, Connie Chen, Sharon Fleischer, Ilaria Baldassarri, Gordana Vunjak-Novakovic   +11 more
doaj   +2 more sources

Optogenetic Control of Human Induced Pluripotent Stem Cell‐Derived Cardiac Tissue Models

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Optogenetics, using light‐sensitive proteins, emerged as a unique experimental paradigm to modulate cardiac excitability. We aimed to develop high‐resolution optogenetic approaches to modulate electrical activity in 2‐ and 3‐dimensional ...
Amit Gruber, Oded Edri, Shany Glatstein, Idit Goldfracht, Irit Huber, Gil Arbel, Amira Gepstein, Snizhanna Chorna, Lior Gepstein   +8 more
doaj   +1 more source

Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues

iScience, 2023
Summary: Cardiac in vitro models have become increasingly obtainable and affordable with the optimization of human pluripotent stem cell-derived cardiomyocyte (hPSC-CM) differentiation.
Shangli Cheng, David Brenière-Letuffe, Virpi Ahola, Andy O.T. Wong, Hoi Yee Keung, Bimal Gurung, Zongli Zheng, Kevin D. Costa, Deborah K. Lieu, Wendy Keung, Ronald A. Li   +10 more
doaj   +1 more source

Combining tissue engineering and optical imaging approaches to explore interactions along the neuro-cardiac axis [PDF]

Royal Society Open Science, 2020
Interactions along the neuro-cardiac axis are being explored with regard to their involvement in cardiac diseases, including catecholaminergic polymorphic ventricular tachycardia, hypertension, atrial fibrillation, long QT syndrome and sudden death in ...
Charalampos Sigalas, Maegan Cremer, Annika Winbo, Samuel J. Bose, Jesse L. Ashton, Gil Bub, Johanna M. Montgomery, Rebecca A. B. Burton   +7 more
doaj   +1 more source

Do Human iPSC-Derived Cardiomyocytes Cultured on PLA Scaffolds Induce Expression of CD28/CTLA-4 by T Lymphocytes?

Journal of Functional Biomaterials, 2022
Many research groups have developed various types of tissue-engineered cardiac constructs. However, the immunological properties of such artificial tissues are not yet fully understood.
David Sergeevichev, Victor Balashov, Victoria Kozyreva, Sophia Pavlova, Maria Vasiliyeva, Alexander Romanov, Elena Chepeleva   +6 more
doaj   +1 more source

Interindividual heterogeneity affects the outcome of human cardiac tissue decellularization

Scientific Reports, 2021
The extracellular matrix (ECM) of engineered human cardiac tissues corresponds to simplistic biomaterials that allow tissue assembly, or animal derived off-the-shelf non-cardiac specific matrices.
Miguel F. Tenreiro, Henrique V. Almeida, Tomás Calmeiro, Elvira Fortunato, Lino Ferreira, Paula M. Alves, Margarida Serra   +6 more
doaj   +1 more source