Results 71 to 80 of about 819,536 (350)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Identifying and Ranking the Components of Engineering Ethics with a Multi-Criteria Decision-Making Approach

آموزش مهندسی ایران, 2020
Engineering ethics deals with moral issues and decisions confronting individuals and organizations engaged in engineering, and it is, therefore, the ability and the responsibility of all engineers to evaluate their decisions based on the general well ...
mahdi safaei , Ardalan Feili , omid jabari , seyed ahmad Jenabali Jahromi   +3 more
doaj   +1 more source

Forming engineers' sociocultural competence: Engineering ethics at Tomsk polytechnic university [PDF]

, 2015
The aim of the present research is to discuss Tomsk Polytechnic University in respect of forming engineers' sociocultural competence and teaching engineering ethics. Today international standards of training engineers cover efficient communication skills,
Dulson, Alfred Andreewitsch, Galanina, Ekaterina Vladimirovna, Schwab, A.   +2 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

TEACHING OF ETHICS IN ENGINEERING UNDERGRADUATE PROGRAMS: TECNOLÓGICO NACIONAL DE MÉXICO’S CASE

Ra Ximhai, 2019
Considering the huge boom that the integration of ethical notions in college education has had in universities around the world, this work is a research about this process in Mexico’s National Tech (TecNM).
Jorge Alberto Olayo-Valles, Estrella Evelyn Armenta-Verdugo, Zenia Isabel Castro-Borunda, María Azucena Caro-Dueñas   +3 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Using Reflexive Principlism to Investigate Longitudinal Changes in Engineering Students’ Perceptions of Ethics

Studies in Engineering Education
Background: Studies of changes in engineering students’ perceptions of ethics and social responsibility over time have often resulted in mixed results or shown only small longitudinal shifts.
Stephanie A. Claussen, Lazlo Stepback, Brent K. Jesiek, Carla B. Zoltowski, Shiloh James Howland   +4 more
doaj   +1 more source

Code of professional ethics of engineering in Iran

آموزش مهندسی ایران, 2015
Professional ethics set of regulations and rules which define ethical practice for that profession specifically. Engineering ethics in general is the application of code of ethics and professional standards.
Mehran Rahmani, Javad Majrouhi
doaj   +1 more source

Teaching engineering ethics with sustainability as context [PDF]

, 2012
Purpose – The purpose of this paper is to ascertain the engagement and response of students to the teaching of engineering ethics incorporating a macro ethical framework whereby sustainability is viewed as context to professional practice.
Byrne, Edmond P.
core   +1 more source