Results 111 to 120 of about 903,268 (304)

CANADIAN ENGINEERS MISSING LEAN THINKING

Proceedings of the Canadian Engineering Education Association (CEEA), 2011
Lean thinking has become a part of North American manufacturing and service sectors. This is occurring in an atmosphere of growing customer demands, heavier reliance upon technology and new environmental challenges. The move to create more agile and responsive organizations has become a global race to perfection and of survival.
openaire   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

ROBOTICS IN PRIMARY SCHOOL: FROM PLAYFUL ACTIVITY TO CONSCIOUS STEM PROJECTING

Неперервна професійна освіта: теорія та практика
The article explores the role of educational robotics as a universal didactic tool within the context of Industry 4.0. The purpose of the study is to substantiate the mechanisms of a systematic transition from playful activity to conscious STEM ...
Marianna Shvardak , Oksana Popovych
doaj   +1 more source

Integrating engineering into medical education: A scoping review

Current Medicine Research and Practice
Background: As healthcare systems grow increasingly complex and technology-driven, there is a pressing need to equip future physicians with problem-solving skills, systems thinking and design principles that define engineering disciplines.
Stephanie Quon, Sarah Thompson, Daniel Nguyen, Emily Carter, Michael Lee   +4 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Different Ways of Thinking about Street Networks and Spatial Analysis

, 2014
Street networks, as one of the oldest infrastructures of transport in the world, play a significant role in modernization, sustainable development, and human daily activities in both ancient and modern times.
Jiang, Bin, Okabe, Atsuyuki
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Engineering Thinking | College of Engineering

, 2015
Nov. 2, 2015 - It’s no surprise: engineering courses are tough. Professors assign complex homework problems that can take hours to solve, and for some the experience feels like drinking from a fire hose. Most engineering programs begin with a handful of rigorous courses in statics and dynamics that can be stumbling blocks for some. This has engineering
openaire   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source