Results 51 to 60 of about 901,591 (284)

Historical roots of Agile methods: where did “Agile thinking” come from? [PDF]

, 2008
The appearance of Agile methods has been the most noticeable change to software process thinking in the last fifteen years [16], but in fact many of the “Agile ideas” have been around since 70’s or even before.
A. Cockburn, A. Cockburn, A. Cockburn, A. Cockburn, B. Boehm, B. Boehm, B. Boehm, C. Larman, D.D. McCracken, E.W. Dijkstra, G. Booch, G.M. Weinberg, I. Sommerville, J. Highsmith, J. Martin, J. Stapleton, K. Beck, K. Schwaber, P. Coad, R. Turner, S. Ambler, S.R. Palmer, T. Gilb   +22 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Bidirectional Teaching Reform in Theoretical Mechanics: Integrating Engineering Thinking and Personalized Assignments

Education Sciences
Traditional theoretical mechanics courses often emphasize the rote learning of principles over practical applications. This focus can diminish student engagement and leave graduates ill prepared for applying concepts to real engineering problems.
Yue Jia, Chun Li
doaj   +1 more source

Assessing the validity and reliability of creative thinking skills module in a pilot study on engineering undergraduate in Malaysia

Asian Journal of Assessment in Teaching and Learning, 2020
This research paper presents the outcome of a research conducted to assess and determine the Validity and Reliability coefficient of Creative Thinking Skills for Conceptual Engineering Design Module administered to engineering undergraduates at a private
Yaw Long Chua, Balamuralithara Balakrishnan, Voon Chiet Chai, Yit Yan Koh   +3 more
doaj   +1 more source

The Missing Basics & Other Philosophical Reflections for the Transformation of Engineering Education [PDF]

, 2009
The paper starts by reflecting on what senior engineering students don't know how to do when they confront a real-world project in an industrially sponsored senior design project. Seven, largely qualitatively, skills are found to be lacking: questioning,
Goldberg, David E.
core   +1 more source

Whole life thinking and engineering the future [PDF]

, 2014
Whole-life thinking for engineers working on the built environment has become more important in a fast changing world.Engineers are increasingly concerned with complex systems, in which the parts interact with each other and with the outside world in ...
Flanagan, Roger
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Developing an undergraduate software engineering degree [PDF]

, 2003
As those who have done it can attest, developing an undergraduate degree in software engineering is a daunting and challenging task, and there have been instances where a department has tried, but failed to get its program approved.
Armarego, J., Bagert, D.J., Eisenbach, S., Hilburn, T.B., Naveda, J.F., Seidman, S.   +5 more
core   +1 more source