Results 51 to 60 of about 903,268 (304)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The phenomenon of engineering thinking in the modern world: Psychological content, structure, components

Russian Journal of Education and Psychology
Background. In the context of rapid technological progress and digitalization of various fields of activity, the importance of engineering thinking is increasing not only in technical, but also in humanitarian professions.
Alexandra A. Nikitinа, Elena A. Mannanova   +1 more
doaj   +1 more source

On the influence of creativity in basic programming learning at a first-year Engineering course [PDF]

, 2016
Teaching fundamentals of programming is a complex task that involves the students’ acquisition of diverse knowledge and skills. It is also well known that programming often requires a certain degree of creativity.
López Álvarez, David, Olmedo Torre, Noelia, Pérez Poch, Antoni, Salán Ballesteros, Maria Núria, Sánchez Carracedo, Fermín   +4 more
core   +1 more source

Historical roots of Agile methods: where did “Agile thinking” come from? [PDF]

, 2008
The appearance of Agile methods has been the most noticeable change to software process thinking in the last fifteen years [16], but in fact many of the “Agile ideas” have been around since 70’s or even before.
A. Cockburn, A. Cockburn, A. Cockburn, A. Cockburn, B. Boehm, B. Boehm, B. Boehm, C. Larman, D.D. McCracken, E.W. Dijkstra, G. Booch, G.M. Weinberg, I. Sommerville, J. Highsmith, J. Martin, J. Stapleton, K. Beck, K. Schwaber, P. Coad, R. Turner, S. Ambler, S.R. Palmer, T. Gilb   +22 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The Missing Basics & Other Philosophical Reflections for the Transformation of Engineering Education [PDF]

, 2009
The paper starts by reflecting on what senior engineering students don't know how to do when they confront a real-world project in an industrially sponsored senior design project. Seven, largely qualitatively, skills are found to be lacking: questioning,
Goldberg, David E.
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Bidirectional Teaching Reform in Theoretical Mechanics: Integrating Engineering Thinking and Personalized Assignments

Education Sciences
Traditional theoretical mechanics courses often emphasize the rote learning of principles over practical applications. This focus can diminish student engagement and leave graduates ill prepared for applying concepts to real engineering problems.
Yue Jia, Chun Li
doaj   +1 more source

Innovative thinking development in engineers

Journal of Physics: Conference Series, 2020
Abstract Innovative thinking may be considered as a certain type of thinking both “serving” engineering and ensuring its success. Innovative thinking is to become a basic resource of experts in engineering. The article defines main components of innovative thinking (technical thinking, creative thinking and critical thinking).
K O Sokolov, I A Sergeicheva, M I Sokolova   +2 more
openaire   +1 more source