Results 81 to 90 of about 903,268 (304)

Applying Systems Thinking to Engineering and Design

open access: yesSystems, 2018
The application of Systems Thinking principles to Systems Engineering is synergistic, resulting in superior systems, products, and designs. However, there is little practical information available in the literature that describes how this can be done. In
Jamie P. Monat, Thomas F. Gannon
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Development theories and development experience: half a century journey [PDF]

open access: yes
This paper examines the impact that development theories have had on development policies, and the inverse impact of actual successes and failures in the global South on development thinking.
Popov, Vladimir
core   +4 more sources

OUTCOMES OF CRITICAL THINKING IN ENGINEERING EDUCATION: A SYSTEMATIC REVIEW

open access: yesآموزش مهندسی ایران
Identifying, cultivating, and developing critical thinking competencies is one of the most important success factors of engineers in problem-finding, problem-oriented, problematizing and recognizing innovative solutions and solving complex problems.
Zahra Akbaripordanjani , Keyvan Salehi
doaj   +1 more source

CONTINUING EDUCATION MODEL OF SCHOOL OF FUTURE (CASE STUDY OF ENGINEERING SCHOOL)

open access: yesОткрытое образование (Москва), 2016
The paper presents the concept of continuous engineering education for the educational complex kindergarten-school-high school. Basing on the space-time model of memory and thinking, we define the didactic requirements for organization of the educational
Olga A. Karlova, Nikolay I. Pak
doaj   +1 more source

Safe Environments for Innovation: the development of a new multidisciplinary masters programme [PDF]

open access: yes, 2010
In September 2007, three schools at Northumbria University came together in collaboration to create a Masters Programme in Multidisciplinary Design Innovation (MDI).
Bailey, Mark
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

PENDEKATAN STREAM (SCIENCE-TECHNOLOGY-RELIGION-ENGINEERING-ARTS-MATHEMATICS) MEMBEKALKAN KEBIASAAN BERPIKIR MAHASISWA

open access: yesEDUSAINS, 2020
THE STREAM APPROACH (SCIENCE-TECHNOLOGY-RELIGION-ENGINEERING-ARTS-MATHEMATICS) PROVIDES STUDENTS 'THINKING HABITS Abstract This research develops an Applied Biology learning program using a science-technology-religion-engineering-arts-mathematics (STREAM)
Tri Wahyu Agustina   +3 more
doaj   +1 more source

Identifying Pertinent Elements of Critical Thinking and Mathematical Thinking Used in Civil Engineering Practice in Relation to Engineering Education [PDF]

open access: yes, 2016
Engaging critical thinking and mathematical thinking in solving engineering problems is a way of approaching the engineering criteria of Engineering Accreditation Council, Board of Engineers Malaysia.
Abu, Mohd Salleh bin   +3 more
core   +1 more source

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