Results 1 to 10 of about 8,887,574 (403)
Diversity and Emerging Roles of Enhancer RNA in Regulation of Gene Expression and Cell Fate
Frontiers in Cell and Developmental Biology, 2020 Enhancers are cis-regulatory elements in the genome that cooperate with promoters to control target gene transcription. Unlike promoters, enhancers are not necessarily adjacent to target genes and can exert their functions regardless of enhancer ...
Preston R. Arnold +3 more
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Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity [PDF]
eLife, 2019 Developmental enhancers integrate graded concentrations of transcription factors (TFs) to create sharp gene expression boundaries. Here we examine the hunchback P2 (HbP2) enhancer which drives a sharp expression pattern in the Drosophila blastoderm ...
Jeehae Park +10 more
doaj +3 more sources
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
Nature, 2015 Enhancers, critical determinants of cellular identity, are commonly recognized by correlative chromatin marks and gain-of-function potential, although only loss-of-function studies can demonstrate their requirement in the native genomic context ...
Matthew C Canver +2 more
exaly +2 more sources
Enhancer release and retargeting activates disease-susceptibility genes
Nature, 2021 Joydeep Mitra +2 more
exaly +2 more sources
Establishment and function of chromatin modification at enhancers [PDF]
Open Biology, 2020 How a single genome can give rise to distinct cell types remains a fundamental question in biology. Mammals are able to specify and maintain hundreds of cell fates by selectively activating unique subsets of their genome.
Amanuel Tafessu, Laura A. Banaszynski
doaj +1 more source
Genome-Wide Histone Modifications and CTCF Enrichment Predict Gene Expression in Sheep Macrophages
Frontiers in Genetics, 2021 Alveolar macrophages function in innate and adaptive immunity, wound healing, and homeostasis in the lungs dependent on tissue-specific gene expression under epigenetic regulation.
Alisha T. Massa +9 more
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Nonlinear control of transcription through enhancer–promoter interactions
Nature, 2021 Chromosome structure in mammals is thought to regulate transcription by modulating three-dimensional interactions between enhancers and promoters, notably through CTCF-mediated loops and topologically associating domains (TADs)1–4.
J. Zuin +15 more
semanticscholar +1 more source
Frontiers in Genetics, 2022 G-quadruplex (G4) has been previously observed to be associated with gene expression. In this study, we performed integrative analysis on G4 multi-omics data from in-silicon prediction and ChIP-seq in human genome. Potential G4 sites were classified into
Shuyi Fang +13 more
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Mechanisms of enhancer action: the known and the unknown
Genome Biology, 2021 Differential gene expression mechanisms ensure cellular differentiation and plasticity to shape ontogenetic and phylogenetic diversity of cell types.
A. Panigrahi, B. O’Malley
semanticscholar +1 more source
Frontiers in Immunology, 2022 γδ T cells play important roles in immune responses by rapidly producing large quantities of cytokines. Recently, γδ T cells have been found to be involved in tissue homeostatic regulation, playing roles in thermogenesis, bone regeneration and synaptic ...
Alonso Rodríguez-Caparrós +6 more
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