Results 21 to 30 of about 2,230,930 (359)
WormBook, 2005 A genetic enhancer is a mutation in one gene that intensifies the phenotype caused by a mutation in another gene. The phenotype of the double mutant is much stronger than the summation of the single mutant phenotypes. The isolation of enhancers can lead to the identification of interacting genes, including genes that act redundantly with respect to ...
Robert K, Herman, John, Yochem
openaire +2 more sources
eLife, 2017 Sequence variation within enhancers plays a major role in both evolution and disease, yet its functional impact on transcription factor (TF) occupancy and enhancer activity remains poorly understood.
Pierre Khoueiry +6 more
doaj +1 more source
HoxA9 binds and represses the Cebpa +8 kb enhancer [PDF]
, 2019 C/EBPα plays a key role in specifying myeloid lineage development. HoxA9 is expressed in myeloid progenitors, with its level diminishing during myeloid maturation, and HOXA9 is over-expressed in a majority of acute myeloid leukemia cases, including those
Aplan, Peter D. +7 more
core +2 more sources
Frontiers in Immunology, 2018 The presence of abnormal gene expression signatures is a well-described feature of the oligoarticular and polyarticular forms of juvenile idiopathic arthritis.
Haeja Kessler +3 more
doaj +1 more source
Disparate expression specificities coded by a shared Hox-C enhancer
eLife, 2020 Can a single regulatory sequence be shared by two genes undergoing functional divergence? Here we describe a single promiscuous enhancer within the Drosophila Antennapedia Complex, EO053, that directs aspects of the expression of two adjacent genes, pb ...
Steve W Miller, James W Posakony
doaj +1 more source
Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs cellular reprogramming [PDF]
, 2013 Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes ...
A Calender +117 more
core +3 more sources
eLife, 2019 Developmental enhancers integrate graded concentrations of transcription factors (TFs) to create sharp gene expression boundaries. Here we examine the hunchback P2 (HbP2) enhancer which drives a sharp expression pattern in the Drosophila blastoderm ...
Jeehae Park +10 more
doaj +1 more source
Shared enhancer gene regulatory networks between wound and oncogenic programs
eLife, 2023 Wound response programs are often activated during neoplastic growth in tumors. In both wound repair and tumor growth, cells respond to acute stress and balance the activation of multiple programs, including apoptosis, proliferation, and cell migration ...
Swann Floc'hlay +14 more
doaj +1 more source
Frontiers in Oncology, 2023 Breast cancer biology varies markedly among patients. Basal-like breast cancer is one of the most challenging subtypes to treat because it lacks effective therapeutic targets.
Kohei Kumegawa +4 more
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A long and complex enhancer activates transcription of the gene coding for the highly abundant immediate early mRNA in murine cytomegalovirus [PDF]
, 1985 Using the simian virus 40 "enhancer trap" approach, we have identified a transcription enhancer located just upstream of the major immediate early gene of murine cytomegalovirus. This enhancer has several striking properties.
Dorsch-Häsler, Karoline +5 more
core +1 more source