Results 21 to 30 of about 8,887,574 (403)
Achievement and Enhancement [PDF]
Canadian Journal of Philosophy, 2019 AbstractWe engage with the nature and the value of achievement through a critical examination of an argument according to which biomedical “enhancement” of our capacities is impermissible because enhancing ourselves in this way would threaten our achievements. We call this the argument against enhancement from achievement.
Lisa Forsberg, Anthony Skelton
openaire +3 more sources
Frontiers in Physiology, 2021 Cardiac pacemaker cells differentiate and functionally specialize early in embryonic development through activation of critical gene regulatory networks.
Ravi Mandla +2 more
doaj +1 more source
Oligonucleotide that binds nuclear factor NF-kappa-B acts as a lymphoid-specific and inducible enhancer element [PDF]
, 1988 The immunoglobulin kappa light chain gene contains a lymphoid-specific enhancer that includes several short protein-binding sequences. The sequence that binds the nuclear factor NF-kappa B was tested for its ability to act independently as an enhancer ...
Baltimore, David +2 more
core +2 more sources
A long and complex enhancer activates transcription of the gene coding for the highly abundant immediate early mRNA in murine cytomegalovirus [PDF]
, 1985 Using the simian virus 40 "enhancer trap" approach, we have identified a transcription enhancer located just upstream of the major immediate early gene of murine cytomegalovirus. This enhancer has several striking properties.
Dorsch-Häsler, Karoline +5 more
core +1 more source
HoxA9 binds and represses the Cebpa +8 kb enhancer [PDF]
, 2019 C/EBPα plays a key role in specifying myeloid lineage development. HoxA9 is expressed in myeloid progenitors, with its level diminishing during myeloid maturation, and HOXA9 is over-expressed in a majority of acute myeloid leukemia cases, including those
Aplan, Peter D. +7 more
core +2 more sources
Frontiers in Cell and Developmental Biology, 2021 Thyroid carcinoma (TC) is the most common endocrine malignancy, and papillary TC (PTC) is the most frequent subtype of TC, accounting for 85–90% of all the cases. Aberrant histone acetylation contributes to carcinogenesis by inducing the dysregulation of
Luyao Zhang +16 more
doaj +1 more source
The strong enhancer element in the immediate early region of the human cytomegalovirus genome [PDF]
, 1985 The human cytomegalovirus (HCMV), a member of the herpesvirus group, was found to possess a strong transcription enhancer in the immediate early gene region. Co-transfection of enhancerless SV40 DNA with randomly fragmented HCMV DNA yielded two SV40-
Boshart, Michael +9 more
core +1 more source
Pluripotency factors functionally premark cell-type-restricted enhancers in ES cells. [PDF]
, 2018 Enhancers for embryonic stem (ES) cell-expressed genes and lineage-determining factors are characterized by conventional marks of enhancer activation in ES cells1-3, but it remains unclear whether enhancers destined to regulate cell-type-restricted ...
Destici, Eugin +10 more
core +2 more sources
Frontiers in Genetics, 2021 Enhancers are regulatory DNA sequences that could be bound by specific proteins named transcription factors (TFs). The interactions between enhancers and TFs regulate specific genes by increasing the target gene expression.
Kun Niu +5 more
doaj +1 more source